TLRN1_HUMAN
ID TLRN1_HUMAN Reviewed; 362 AA.
AC Q9H1K6;
DT 25-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Talin rod domain-containing protein 1 {ECO:0000305};
DE AltName: Full=Mesoderm development candidate 1 {ECO:0000312|HGNC:HGNC:13519};
GN Name=TLNRD1 {ECO:0000312|HGNC:HGNC:13519};
GN Synonyms=MESDC1 {ECO:0000312|HGNC:HGNC:13519};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Retina;
RX PubMed=11247670; DOI=10.1006/geno.2000.6466;
RA Wines M.E., Lee L., Katari M.S., Zhang L., DeRossi C., Shi Y., Perkins S.,
RA Feldman M., McCombie W.R., Holdener B.C.;
RT "Identification of mesoderm development (mesd) candidate genes by
RT comparative mapping and genome sequence analysis.";
RL Genomics 72:88-98(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [4]
RP FUNCTION, AND INDUCTION BY MIR574-3P.
RX PubMed=22179486; DOI=10.3892/ijo.2011.1294;
RA Tatarano S., Chiyomaru T., Kawakami K., Enokida H., Yoshino H., Hidaka H.,
RA Nohata N., Yamasaki T., Gotanda T., Tachiwada T., Seki N., Nakagawa M.;
RT "Novel oncogenic function of mesoderm development candidate 1 and its
RT regulation by MiR-574-3p in bladder cancer cell lines.";
RL Int. J. Oncol. 40:951-959(2012).
CC -!- FUNCTION: Actin-binding protein which may have an oncogenic function
CC and regulates cell proliferation, migration and invasion in cancer
CC cells. {ECO:0000269|PubMed:22179486}.
CC -!- SUBUNIT: May homodimerize. Interacts with F-actin.
CC {ECO:0000250|UniProtKB:Q9ERE8}.
CC -!- INTERACTION:
CC Q9H1K6; Q9BSQ5: CCM2; NbExp=3; IntAct=EBI-12344941, EBI-1573056;
CC Q9H1K6; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-12344941, EBI-79165;
CC Q9H1K6; O14492-2: SH2B2; NbExp=3; IntAct=EBI-12344941, EBI-19952306;
CC Q9H1K6; Q9H1K6: TLNRD1; NbExp=3; IntAct=EBI-12344941, EBI-12344941;
CC -!- INDUCTION: Down-regulated by microRNA MIR574-3p.
CC {ECO:0000269|PubMed:22179486}.
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DR EMBL; AY007810; AAG41058.1; -; mRNA.
DR EMBL; BC084554; AAH84554.1; -; mRNA.
DR CCDS; CCDS10316.1; -.
DR RefSeq; NP_072088.1; NM_022566.2.
DR PDB; 6XZ3; X-ray; 2.19 A; A=143-273.
DR PDB; 6XZ4; X-ray; 2.30 A; A/B=1-362.
DR PDBsum; 6XZ3; -.
DR PDBsum; 6XZ4; -.
DR AlphaFoldDB; Q9H1K6; -.
DR SMR; Q9H1K6; -.
DR BioGRID; 121865; 17.
DR IntAct; Q9H1K6; 3.
DR STRING; 9606.ENSP00000267984; -.
DR iPTMnet; Q9H1K6; -.
DR PhosphoSitePlus; Q9H1K6; -.
DR BioMuta; TLNRD1; -.
DR DMDM; 24418561; -.
DR EPD; Q9H1K6; -.
DR jPOST; Q9H1K6; -.
DR MassIVE; Q9H1K6; -.
DR MaxQB; Q9H1K6; -.
DR PaxDb; Q9H1K6; -.
DR PeptideAtlas; Q9H1K6; -.
DR PRIDE; Q9H1K6; -.
DR ProteomicsDB; 80425; -.
DR Antibodypedia; 63061; 25 antibodies from 10 providers.
DR DNASU; 59274; -.
DR Ensembl; ENST00000267984.4; ENSP00000267984.2; ENSG00000140406.4.
DR GeneID; 59274; -.
DR KEGG; hsa:59274; -.
DR MANE-Select; ENST00000267984.4; ENSP00000267984.2; NM_022566.3; NP_072088.1.
DR UCSC; uc002bfz.4; human.
DR CTD; 59274; -.
DR DisGeNET; 59274; -.
DR GeneCards; TLNRD1; -.
DR HGNC; HGNC:13519; TLNRD1.
DR HPA; ENSG00000140406; Low tissue specificity.
DR MIM; 615466; gene.
DR neXtProt; NX_Q9H1K6; -.
DR OpenTargets; ENSG00000140406; -.
DR PharmGKB; PA30760; -.
DR VEuPathDB; HostDB:ENSG00000140406; -.
DR eggNOG; KOG4261; Eukaryota.
DR GeneTree; ENSGT00910000144335; -.
DR HOGENOM; CLU_764970_0_0_1; -.
DR InParanoid; Q9H1K6; -.
DR OMA; EQSCGVL; -.
DR OrthoDB; 1284476at2759; -.
DR PhylomeDB; Q9H1K6; -.
DR PathwayCommons; Q9H1K6; -.
DR SignaLink; Q9H1K6; -.
DR BioGRID-ORCS; 59274; 16 hits in 1083 CRISPR screens.
DR ChiTaRS; MESDC1; human.
DR GenomeRNAi; 59274; -.
DR Pharos; Q9H1K6; Tdark.
DR PRO; PR:Q9H1K6; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q9H1K6; protein.
DR Bgee; ENSG00000140406; Expressed in ileal mucosa and 183 other tissues.
DR Genevisible; Q9H1K6; HS.
DR GO; GO:0001725; C:stress fiber; IEA:Ensembl.
DR GO; GO:0003779; F:actin binding; ISS:HGNC.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR InterPro; IPR042799; TLNRD1.
DR PANTHER; PTHR47133; PTHR47133; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:19413330"
FT CHAIN 2..362
FT /note="Talin rod domain-containing protein 1"
FT /id="PRO_0000096441"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0007744|PubMed:19413330"
FT HELIX 42..57
FT /evidence="ECO:0007829|PDB:6XZ4"
FT STRAND 61..64
FT /evidence="ECO:0007829|PDB:6XZ4"
FT STRAND 70..72
FT /evidence="ECO:0007829|PDB:6XZ4"
FT HELIX 75..102
FT /evidence="ECO:0007829|PDB:6XZ4"
FT HELIX 105..135
FT /evidence="ECO:0007829|PDB:6XZ4"
FT HELIX 150..169
FT /evidence="ECO:0007829|PDB:6XZ3"
FT HELIX 172..174
FT /evidence="ECO:0007829|PDB:6XZ3"
FT HELIX 177..204
FT /evidence="ECO:0007829|PDB:6XZ3"
FT HELIX 208..237
FT /evidence="ECO:0007829|PDB:6XZ3"
FT HELIX 241..249
FT /evidence="ECO:0007829|PDB:6XZ3"
FT HELIX 251..265
FT /evidence="ECO:0007829|PDB:6XZ3"
FT HELIX 268..270
FT /evidence="ECO:0007829|PDB:6XZ4"
FT HELIX 279..308
FT /evidence="ECO:0007829|PDB:6XZ4"
FT STRAND 310..312
FT /evidence="ECO:0007829|PDB:6XZ4"
FT TURN 313..315
FT /evidence="ECO:0007829|PDB:6XZ4"
FT HELIX 319..341
FT /evidence="ECO:0007829|PDB:6XZ4"
SQ SEQUENCE 362 AA; 37758 MW; 37BF391D663E1D6E CRC64;
MASGSAGKPT GEAASPAPAS AIGGASSQPR KRLVSVCDHC KGKMQLVADL LLLSSEARPV
LFEGPASSGA GAESFEQCRD TIIARTKGLS ILTHDVQSQL NMGRFGEAGD SLVELGDLVV
SLTECSAHAA YLAAVATPGA QPAQPGLVDR YRVTRCRHEV EQGCAVLRAT PLADMTPQLL
LEVSQGLSRN LKFLTDACAL ASDKSRDRFS REQFKLGVKC MSTSASALLA CVREVKVAPS
ELARSRCALF SGPLVQAVSA LVGFATEPQF LGRAAAVSAE GKAVQTAILG GAMSVVSACV
LLTQCLRDLA QHPDGGAKMS DHRERLRNSA CAVSEGCTLL SQALRERSSP RTLPPVNSNS
VN
