TLRN1_MOUSE
ID TLRN1_MOUSE Reviewed; 362 AA.
AC Q9ERE8; Q542D0;
DT 25-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Talin rod domain-containing protein 1 {ECO:0000305};
DE AltName: Full=Mesoderm development candidate 1 {ECO:0000312|MGI:MGI:1891420};
GN Name=Tlnrd1 {ECO:0000250|UniProtKB:Q9H1K6};
GN Synonyms=Mesdc1 {ECO:0000312|MGI:MGI:1891420};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC STRAIN=129/SvJ;
RX PubMed=11247670; DOI=10.1006/geno.2000.6466;
RA Wines M.E., Lee L., Katari M.S., Zhang L., DeRossi C., Shi Y., Perkins S.,
RA Feldman M., McCombie W.R., Holdener B.C.;
RT "Identification of mesoderm development (mesd) candidate genes by
RT comparative mapping and genome sequence analysis.";
RL Genomics 72:88-98(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, Heart, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [5]
RP INTERACTION WITH F-ACTIN, AND SUBUNIT.
RX PubMed=20610383; DOI=10.1074/jbc.m109.095455;
RA Gingras A.R., Bate N., Goult B.T., Patel B., Kopp P.M., Emsley J.,
RA Barsukov I.L., Roberts G.C., Critchley D.R.;
RT "Central region of talin has a unique fold that binds vinculin and actin.";
RL J. Biol. Chem. 285:29577-29587(2010).
CC -!- FUNCTION: Actin-binding protein which may have an oncogenic function
CC and regulates cell proliferation, migration and invasion in cancer
CC cells. {ECO:0000250|UniProtKB:Q9H1K6}.
CC -!- SUBUNIT: May homodimerize. Interacts with F-actin.
CC {ECO:0000269|PubMed:20610383}.
CC -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:11247670}.
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DR EMBL; AF311213; AAG33620.1; -; Genomic_DNA.
DR EMBL; AK084510; BAC39204.1; -; mRNA.
DR EMBL; AK089082; BAC40740.1; -; mRNA.
DR EMBL; AK162446; BAE36922.1; -; mRNA.
DR EMBL; BC018326; AAH18326.1; -; mRNA.
DR CCDS; CCDS21414.1; -.
DR RefSeq; NP_109630.1; NM_030705.4.
DR AlphaFoldDB; Q9ERE8; -.
DR SMR; Q9ERE8; -.
DR STRING; 10090.ENSMUSP00000091769; -.
DR iPTMnet; Q9ERE8; -.
DR PhosphoSitePlus; Q9ERE8; -.
DR EPD; Q9ERE8; -.
DR jPOST; Q9ERE8; -.
DR MaxQB; Q9ERE8; -.
DR PaxDb; Q9ERE8; -.
DR PRIDE; Q9ERE8; -.
DR ProteomicsDB; 260668; -.
DR Antibodypedia; 63061; 25 antibodies from 10 providers.
DR Ensembl; ENSMUST00000094216; ENSMUSP00000091769; ENSMUSG00000070462.
DR GeneID; 80889; -.
DR KEGG; mmu:80889; -.
DR UCSC; uc009idw.1; mouse.
DR CTD; 59274; -.
DR MGI; MGI:1891420; Tlnrd1.
DR VEuPathDB; HostDB:ENSMUSG00000070462; -.
DR eggNOG; KOG4261; Eukaryota.
DR GeneTree; ENSGT00910000144335; -.
DR HOGENOM; CLU_764970_0_0_1; -.
DR InParanoid; Q9ERE8; -.
DR OMA; EQSCGVL; -.
DR OrthoDB; 1284476at2759; -.
DR PhylomeDB; Q9ERE8; -.
DR BioGRID-ORCS; 80889; 6 hits in 71 CRISPR screens.
DR PRO; PR:Q9ERE8; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9ERE8; protein.
DR Bgee; ENSMUSG00000070462; Expressed in embryonic brain and 193 other tissues.
DR Genevisible; Q9ERE8; MM.
DR GO; GO:0003779; F:actin binding; IDA:HGNC.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR InterPro; IPR042799; TLNRD1.
DR PANTHER; PTHR47133; PTHR47133; 1.
PE 1: Evidence at protein level;
KW Acetylation; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:17242355"
FT CHAIN 2..362
FT /note="Talin rod domain-containing protein 1"
FT /id="PRO_0000096442"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0007744|PubMed:17242355"
SQ SEQUENCE 362 AA; 37786 MW; EFE9BBFC09BB7CB5 CRC64;
MASGSAGKPT GEAASPAPGS AVGGASSQPR KRLVSICDHC KGKMQLVADL LLLSSEARPV
LFEGPASPGA GAESFEQCRD TIIARTKGLS ILTHDVQSQL NMGRFGEAGD SLVELGDLVV
SLTECSAHAA YLAAVATPGA QPAQPGLVDR YRVTRCRHEV EQGCAVLRAT PLADMTPQLL
LEVSQGLSRN LKFLTDACAL ASDKSRDRFS REQFKLGVKC MSTSASALLA CVREVKAAPS
ELARSRCALF SGPLVQAVSA LVGFATEPQF LGRAAAVSTE GKAVQTAILG GAMSVVSACV
LLTQCLRDLA QHPDGSAKMS DHRERLRNSA CAVSEGCTLL SQALRERSSP RTLPPVNSNS
VN
