TLS1_SCHPO
ID TLS1_SCHPO Reviewed; 254 AA.
AC Q10148; Q9UTV7;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2012, sequence version 2.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Telomere length and silencing protein 1 {ECO:0000303|PubMed:25245948};
GN Name=tls1 {ECO:0000303|PubMed:25245948}; ORFNames=SPAC1D4.01, SPAC1F3.11;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP REVISION OF GENE MODEL.
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-84, AND SUBCELLULAR
RP LOCATION.
RC STRAIN=ATCC 38364 / 968;
RX PubMed=10759889; DOI=10.1046/j.1365-2443.2000.00317.x;
RA Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T.,
RA Hiraoka Y.;
RT "Large-scale screening of intracellular protein localization in living
RT fission yeast cells by the use of a GFP-fusion genomic DNA library.";
RL Genes Cells 5:169-190(2000).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [5]
RP FUNCTION, AND INTERACTION WITH BRR2.
RX PubMed=25245948; DOI=10.1093/nar/gku842;
RA Wang J., Tadeo X., Hou H., Andrews S., Moresco J.J., Yates J.R. III,
RA Nagy P.L., Jia S.;
RT "Tls1 regulates splicing of shelterin components to control telomeric
RT heterochromatin assembly and telomere length.";
RL Nucleic Acids Res. 42:11419-11432(2014).
CC -!- FUNCTION: Involved in the regulation of heterochromatin assembly at
CC telomeric regions. Involved in the control of telomere length.
CC Regulates spliceosome assembly by associating with brr2. Regulates the
CC proper splicing of mRNAs of the shelterin components rap1 and poz1 to
CC control telomeric heterochromatin assembly and telomere length.
CC {ECO:0000269|PubMed:25245948}.
CC -!- SUBUNIT: Interacts with brr2. {ECO:0000269|PubMed:25245948}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the TLS1 family.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA87273.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU329670; CAA94629.3; -; Genomic_DNA.
DR EMBL; AB027969; BAA87273.1; ALT_INIT; Genomic_DNA.
DR PIR; T38042; T38042.
DR RefSeq; XP_001713042.2; XM_001712990.2.
DR AlphaFoldDB; Q10148; -.
DR SMR; Q10148; -.
DR BioGRID; 857999; 54.
DR STRING; 4896.SPAC1D4.01.1; -.
DR iPTMnet; Q10148; -.
DR MaxQB; Q10148; -.
DR PaxDb; Q10148; -.
DR PRIDE; Q10148; -.
DR EnsemblFungi; SPAC1D4.01.1; SPAC1D4.01.1:pep; SPAC1D4.01.
DR PomBase; SPAC1D4.01; tls1.
DR VEuPathDB; FungiDB:SPAC1D4.01; -.
DR HOGENOM; CLU_1195470_0_0_1; -.
DR InParanoid; Q10148; -.
DR OMA; EPHEAND; -.
DR PRO; PR:Q10148; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0005681; C:spliceosomal complex; IDA:PomBase.
DR GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IMP:PomBase.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR InterPro; IPR010756; Tls1.
DR PANTHER; PTHR13486; PTHR13486; 1.
DR Pfam; PF07052; Hep_59; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..254
FT /note="Telomere length and silencing protein 1"
FT /id="PRO_0000116466"
FT REGION 69..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 254 AA; 29446 MW; F159231177FA5398 CRC64;
MNSIHIKKKS NRSFRRRKVF GNEKEFDLEE LDDNDIRLRQ ALEATKRRKI RNSIIGINAE
KLLNQETKKE KQLNTANEPH EANDQTSAQS SKLIEAQLPT VEDRFAKQTN EVDINTHLLN
FVEKKLKQER LAQNYSENGE TNALNTKNES TVQNIKNSLH PNEHSFIRDA AALGAIREVD
LGIISTDVDN LKNGRKRQKK RARMKEKLDS KALRTSEDAA RDEFIEKMLK PISQDEESKG
IYRRFRVYKD GTQD