ID   TLX1_CHICK              Reviewed;         297 AA.
AC   O93366;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=T-cell leukemia homeobox protein 1;
DE   AltName: Full=Homeobox TLX-1;
DE   AltName: Full=Homeobox protein Hox-11;
GN   Name=TLX1; Synonyms=HOX11;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Rhode Island red;
RX   PubMed=9651221; DOI=10.1523/jneurosci.18-14-05389.1998;
RA   Logan C.C., Wingate R.J.T., McKay I.J., Lumsden A.;
RT   "Tlx-1 and Tlx-3 homeobox gene expression in cranial sensory ganglia and
RT   hindbrain of the chick embryo: markers of patterned connectivity.";
RL   J. Neurosci. 18:5389-5402(1998).
CC   -!- FUNCTION: Seems to be involved in the development of cranial sensory
CC       innervation from peripheral ganglia.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
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DR   EMBL; AF071874; AAC23900.1; -; mRNA.
DR   RefSeq; NP_990346.1; NM_205015.1.
DR   AlphaFoldDB; O93366; -.
DR   SMR; O93366; -.
DR   STRING; 9031.ENSGALP00000012693; -.
DR   PaxDb; O93366; -.
DR   Ensembl; ENSGALT00000012707; ENSGALP00000012693; ENSGALG00000007831.
DR   GeneID; 395868; -.
DR   KEGG; gga:395868; -.
DR   CTD; 3195; -.
DR   VEuPathDB; HostDB:geneid_395868; -.
DR   eggNOG; KOG0488; Eukaryota.
DR   GeneTree; ENSGT00940000158698; -.
DR   HOGENOM; CLU_053409_3_0_1; -.
DR   InParanoid; O93366; -.
DR   OMA; DYGHPAY; -.
DR   OrthoDB; 1391465at2759; -.
DR   PhylomeDB; O93366; -.
DR   PRO; PR:O93366; -.
DR   Proteomes; UP000000539; Chromosome 6.
DR   Bgee; ENSGALG00000007831; Expressed in spleen and 3 other tissues.
DR   ExpressionAtlas; O93366; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0048513; P:animal organ development; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR042247; TLX1/2/3.
DR   PANTHER; PTHR45921; PTHR45921; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..297
FT                   /note="T-cell leukemia homeobox protein 1"
FT                   /id="PRO_0000049335"
FT   DNA_BIND        168..227
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          153..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   297 AA;  32426 MW;  2D86A06AA463ADAB CRC64;
     MEHLGAHHLH QGQAEPISFG IDQILNTSEP GSCMVSHPRL QDSADYGLGC IVGSAYNTVT
     GGYGASGGGA GAYGGTSCSM GALPGSYNVN MAVSMNGNAL SSAGGVIRVP AHRPVAGGVH
     QPLSAAVPPV NGMNSLTGLT FPWMESNRRY TKDRFTGHPY QNRTPPKKKK PRTSFTRLQI
     CELEKRFHRQ KYLASAERAA LAKALKMTDA QVKTWFQNRR TKWRRQTAEE REAERQQANR
     ILMQLQQEAF QKTINQPIQA DPICVHNSSL FALQNLQPWS DDSTKITSVT TVASACE