ID   TLX1_MOUSE              Reviewed;         332 AA.
AC   P43345;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=T-cell leukemia homeobox protein 1;
DE   AltName: Full=Homeobox TLX-1;
DE   AltName: Full=Homeobox protein Hox-11;
GN   Name=Tlx1; Synonyms=Hox11, Tlx-1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7908826; DOI=10.1016/0925-4773(93)90016-q;
RA   Raju K., Tang S., Dube I.D., Kamel-Reid S., Bryce D.M., Breitman M.L.;
RT   "Characterization and developmental expression of Tlx-1, the murine homolog
RT   of HOX11.";
RL   Mech. Dev. 44:51-64(1993).
RN   [2]
RP   FUNCTION.
RX   PubMed=7908720; DOI=10.1038/368747a0;
RA   Roberts C.W.M., Shutter J.R., Korsmeyer S.J.;
RT   "Hox11 controls the genesis of the spleen.";
RL   Nature 368:747-749(1994).
RN   [3]
RP   DNA-BINDING.
RX   PubMed=7596820; DOI=10.1093/nar/23.11.1928;
RA   Tang S., Breitman M.L.;
RT   "The optimal binding sequence of the Hox11 protein contains a predicted
RT   recognition core motif.";
RL   Nucleic Acids Res. 23:1928-1935(1995).
CC   -!- FUNCTION: Controls the genesis of the spleen. Binds to the DNA sequence
CC       5'-GGCGGTAAGTGG-3'. {ECO:0000269|PubMed:7908720}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in various embryonic tissues, including
CC       branchial arches, some component of the nervous system and spleen.
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DR   EMBL; S70632; AAB30542.1; -; Genomic_DNA.
DR   EMBL; S70756; AAB30542.1; JOINED; Genomic_DNA.
DR   EMBL; S70629; AAB30542.1; JOINED; Genomic_DNA.
DR   AlphaFoldDB; P43345; -.
DR   SMR; P43345; -.
DR   STRING; 10090.ENSMUSP00000026236; -.
DR   PhosphoSitePlus; P43345; -.
DR   PRIDE; P43345; -.
DR   ProteomicsDB; 262824; -.
DR   MGI; MGI:98769; Tlx1.
DR   eggNOG; KOG0488; Eukaryota.
DR   InParanoid; P43345; -.
DR   PhylomeDB; P43345; -.
DR   PRO; PR:P43345; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; P43345; protein.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0048513; P:animal organ development; IBA:GO_Central.
DR   GO; GO:0048645; P:animal organ formation; IMP:MGI.
DR   GO; GO:0045165; P:cell fate commitment; IMP:MGI.
DR   GO; GO:0008283; P:cell population proliferation; IMP:MGI.
DR   GO; GO:0007417; P:central nervous system development; IMP:MGI.
DR   GO; GO:0048535; P:lymph node development; TAS:MGI.
DR   GO; GO:0030182; P:neuron differentiation; IMP:MGI.
DR   GO; GO:2000648; P:positive regulation of stem cell proliferation; IMP:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0048536; P:spleen development; IMP:MGI.
DR   GO; GO:0072089; P:stem cell proliferation; IMP:MGI.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR042247; TLX1/2/3.
DR   PANTHER; PTHR45921; PTHR45921; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..332
FT                   /note="T-cell leukemia homeobox protein 1"
FT                   /id="PRO_0000049334"
FT   DNA_BIND        203..262
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   MOD_RES         238
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P31314"
SQ   SEQUENCE   332 AA;  34644 MW;  79FC71E2E44E6F82 CRC64;
     MEHLGPHHLH PGHAEPISFG IEQILNSPDQ GGCMGPNSRL QDGDYGLGCL VPGAYTYGGG
     GSAAGAGAGG TGAYGAGGPG GPGGPAGGGG GACSMGPLPG SYNVNMDLAG GPGPGGDGGG
     GGAARRALSA AGVIRVPAHR PLAGAVAHPQ PLATGLPTVP SVPAVPGVNN LTGLTFPWME
     SNRRYTKDRF TGLPYQNRTP PKKKKPRTSF TRLQICELEK RFHRQKYLAS AERAALAKAL
     KMTDAQVKTW FQNRRTKWRR QTAEEREAES EQANRILLQL QQEAFQKSLA QPLPADPLCV
     HNSSLFALQN LQPWSDDSTK ITSVTSVASA CE