ID   TLX3_CHICK              Reviewed;         297 AA.
AC   O93367;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=T-cell leukemia homeobox protein 3;
DE   AltName: Full=Homeobox TLX-3;
DE   AltName: Full=Homeobox protein Hox-11L2;
GN   Name=TLX3; Synonyms=HOX11L2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Rhode Island red;
RX   PubMed=9651221; DOI=10.1523/jneurosci.18-14-05389.1998;
RA   Logan C.C., Wingate R.J.T., McKay I.J., Lumsden A.;
RT   "Tlx-1 and Tlx-3 homeobox gene expression in cranial sensory ganglia and
RT   hindbrain of the chick embryo: markers of patterned connectivity.";
RL   J. Neurosci. 18:5389-5402(1998).
CC   -!- FUNCTION: Seems to be involved in the development of cranial sensory
CC       innervation from peripheral ganglia.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- TISSUE SPECIFICITY: Expression is restricted to neurons in the
CC       peripheral and central nervous system.
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DR   EMBL; AF071875; AAC23901.1; -; mRNA.
DR   AlphaFoldDB; O93367; -.
DR   SMR; O93367; -.
DR   STRING; 9031.ENSGALP00000003422; -.
DR   PaxDb; O93367; -.
DR   VEuPathDB; HostDB:geneid_107054494; -.
DR   eggNOG; KOG0488; Eukaryota.
DR   HOGENOM; CLU_053409_3_0_1; -.
DR   InParanoid; O93367; -.
DR   PhylomeDB; O93367; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0048513; P:animal organ development; IBA:GO_Central.
DR   GO; GO:0007417; P:central nervous system development; IEA:Ensembl.
DR   GO; GO:0097154; P:GABAergic neuron differentiation; IEA:Ensembl.
DR   GO; GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
DR   GO; GO:0048665; P:neuron fate specification; IEA:Ensembl.
DR   GO; GO:0001764; P:neuron migration; IEA:Ensembl.
DR   GO; GO:0002087; P:regulation of respiratory gaseous exchange by nervous system process; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0007585; P:respiratory gaseous exchange by respiratory system; IEA:Ensembl.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR042247; TLX1/2/3.
DR   PANTHER; PTHR45921; PTHR45921; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..297
FT                   /note="T-cell leukemia homeobox protein 3"
FT                   /id="PRO_0000049340"
FT   DNA_BIND        172..231
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..68
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..55
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   297 AA;  32369 MW;  0C7C9A73E371A38E CRC64;
     MEPAAGAQGP HQHEPISFGI DQILSGPEQD GAPPPPPPPP PPPPPPPPPP RGPDGAAFLG
     GPRGGAPYPA LPGPFPAIAA PFEESGPYGV NLSLAPGGVI RVPAHRPIPG AVPPPVPSAI
     PAVPGLGGLS FPWMESSRRF VKERFTAAAA LTPFTVTRRI GHPYQNRTPP KRKKPRTSFS
     RVQICELEKR FHRQKYLASA ERAALAKSLK MTDAQVKTWF QNRRTKWRRQ TAEEREAERQ
     QASRLMLQLQ HDAFQKSLNE SIQPDPLCLH NSSLFALQNL QPWEEESAKI PPVTSLV