TLX3_HUMAN
ID TLX3_HUMAN Reviewed; 291 AA.
AC O43711; Q96AD3;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 3.
DT 03-AUG-2022, entry version 179.
DE RecName: Full=T-cell leukemia homeobox protein 3;
DE AltName: Full=Homeobox protein Hox-11L2;
GN Name=TLX3; Synonyms=HOX11L2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Delgado P., Rodriguez R., Gonzalez-Sarmiento R.;
RT "Genomic characterization of the human and mouse HOX11L2 genes.";
RL Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC O43711; Q03154: ACY1; NbExp=3; IntAct=EBI-3939165, EBI-742064;
CC O43711; Q6PJH3: AKAP9; NbExp=3; IntAct=EBI-3939165, EBI-11745576;
CC O43711; Q9NXR5-2: ANKRD10; NbExp=5; IntAct=EBI-3939165, EBI-12102070;
CC O43711; Q7Z3H0-1: ANKRD33; NbExp=3; IntAct=EBI-3939165, EBI-16746154;
CC O43711; P19801: AOC1; NbExp=3; IntAct=EBI-3939165, EBI-12826295;
CC O43711; Q7Z5R6-2: APBB1IP; NbExp=3; IntAct=EBI-3939165, EBI-12059807;
CC O43711; Q96C12: ARMC5; NbExp=3; IntAct=EBI-3939165, EBI-6425121;
CC O43711; Q8WXK4-2: ASB12; NbExp=3; IntAct=EBI-3939165, EBI-18394052;
CC O43711; P61421: ATP6V0D1; NbExp=3; IntAct=EBI-3939165, EBI-954063;
CC O43711; Q9BPU9: B9D2; NbExp=3; IntAct=EBI-3939165, EBI-6958971;
CC O43711; Q9NP55: BPIFA1; NbExp=3; IntAct=EBI-3939165, EBI-953896;
CC O43711; Q9H5F2: C11orf1; NbExp=3; IntAct=EBI-3939165, EBI-718615;
CC O43711; Q8TAV5: C11orf45; NbExp=3; IntAct=EBI-3939165, EBI-12810853;
CC O43711; Q5BKX5-3: C19orf54; NbExp=3; IntAct=EBI-3939165, EBI-11976299;
CC O43711; Q9NWW7: C2orf42; NbExp=3; IntAct=EBI-3939165, EBI-2812028;
CC O43711; P40199: CEACAM6; NbExp=3; IntAct=EBI-3939165, EBI-4314501;
CC O43711; O43186: CRX; NbExp=3; IntAct=EBI-3939165, EBI-748171;
CC O43711; P67870: CSNK2B; NbExp=3; IntAct=EBI-3939165, EBI-348169;
CC O43711; Q9UI47-2: CTNNA3; NbExp=3; IntAct=EBI-3939165, EBI-11962928;
CC O43711; O95967: EFEMP2; NbExp=3; IntAct=EBI-3939165, EBI-743414;
CC O43711; Q7Z444: ERAS; NbExp=3; IntAct=EBI-3939165, EBI-13351543;
CC O43711; A8MTA8-2: FAM166B; NbExp=3; IntAct=EBI-3939165, EBI-12160437;
CC O43711; A1KXE4-2: FAM168B; NbExp=3; IntAct=EBI-3939165, EBI-12193763;
CC O43711; Q8N0W3: FCSK; NbExp=3; IntAct=EBI-3939165, EBI-4291312;
CC O43711; P49356: FNTB; NbExp=3; IntAct=EBI-3939165, EBI-602349;
CC O43711; P53539: FOSB; NbExp=3; IntAct=EBI-3939165, EBI-2806743;
CC O43711; O75593: FOXH1; NbExp=3; IntAct=EBI-3939165, EBI-1759806;
CC O43711; Q14390: GGTLC2; NbExp=3; IntAct=EBI-3939165, EBI-12903880;
CC O43711; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-3939165, EBI-5916454;
CC O43711; Q16082: HSPB2; NbExp=3; IntAct=EBI-3939165, EBI-739395;
CC O43711; Q6UWQ7-2: IGFL2; NbExp=3; IntAct=EBI-3939165, EBI-18115692;
CC O43711; Q5TA45: INTS11; NbExp=3; IntAct=EBI-3939165, EBI-748258;
CC O43711; Q6UXX5: ITIH6; NbExp=3; IntAct=EBI-3939165, EBI-11028396;
CC O43711; O76011: KRT34; NbExp=3; IntAct=EBI-3939165, EBI-1047093;
CC O43711; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-3939165, EBI-1052037;
CC O43711; Q3SY46: KRTAP13-3; NbExp=3; IntAct=EBI-3939165, EBI-10241252;
CC O43711; Q8IUB9: KRTAP19-1; NbExp=3; IntAct=EBI-3939165, EBI-12811111;
CC O43711; Q3SYF9: KRTAP19-7; NbExp=3; IntAct=EBI-3939165, EBI-10241353;
CC O43711; Q9BYR8: KRTAP3-1; NbExp=3; IntAct=EBI-3939165, EBI-9996449;
CC O43711; Q3LI64: KRTAP6-1; NbExp=3; IntAct=EBI-3939165, EBI-12111050;
CC O43711; Q3LI66: KRTAP6-2; NbExp=5; IntAct=EBI-3939165, EBI-11962084;
CC O43711; Q8IUC3: KRTAP7-1; NbExp=3; IntAct=EBI-3939165, EBI-18394498;
CC O43711; Q8IUC2: KRTAP8-1; NbExp=3; IntAct=EBI-3939165, EBI-10261141;
CC O43711; Q14847-2: LASP1; NbExp=5; IntAct=EBI-3939165, EBI-9088686;
CC O43711; Q9Y5V3: MAGED1; NbExp=3; IntAct=EBI-3939165, EBI-716006;
CC O43711; Q8N6F8: METTL27; NbExp=3; IntAct=EBI-3939165, EBI-8487781;
CC O43711; Q5VZ52: MORN5; NbExp=3; IntAct=EBI-3939165, EBI-12835568;
CC O43711; P35548: MSX2; NbExp=3; IntAct=EBI-3939165, EBI-6447480;
CC O43711; O14561: NDUFAB1; NbExp=5; IntAct=EBI-3939165, EBI-1246261;
CC O43711; P0CG21: NHLRC4; NbExp=3; IntAct=EBI-3939165, EBI-12868744;
CC O43711; Q9BSH3: NICN1; NbExp=3; IntAct=EBI-3939165, EBI-13324229;
CC O43711; O43482: OIP5; NbExp=3; IntAct=EBI-3939165, EBI-536879;
CC O43711; O15496: PLA2G10; NbExp=3; IntAct=EBI-3939165, EBI-726466;
CC O43711; Q9HDD0: PLAAT1; NbExp=3; IntAct=EBI-3939165, EBI-12387058;
CC O43711; Q16633: POU2AF1; NbExp=3; IntAct=EBI-3939165, EBI-943588;
CC O43711; P78424: POU6F2; NbExp=3; IntAct=EBI-3939165, EBI-12029004;
CC O43711; P86480: PRR20D; NbExp=3; IntAct=EBI-3939165, EBI-12754095;
CC O43711; A5LHX3: PSMB11; NbExp=3; IntAct=EBI-3939165, EBI-19951687;
CC O43711; Q04864-2: REL; NbExp=3; IntAct=EBI-3939165, EBI-10829018;
CC O43711; Q01974: ROR2; NbExp=3; IntAct=EBI-3939165, EBI-6422642;
CC O43711; Q96LW2: RSKR; NbExp=3; IntAct=EBI-3939165, EBI-1054572;
CC O43711; P05121: SERPINE1; NbExp=3; IntAct=EBI-3939165, EBI-953978;
CC O43711; Q16348: SLC15A2; NbExp=3; IntAct=EBI-3939165, EBI-12806032;
CC O43711; Q2TAY7: SMU1; NbExp=3; IntAct=EBI-3939165, EBI-298027;
CC O43711; Q5T0L3: SPATA46; NbExp=3; IntAct=EBI-3939165, EBI-750105;
CC O43711; Q5W111-2: SPRYD7; NbExp=3; IntAct=EBI-3939165, EBI-12408727;
CC O43711; Q8IWL8: STH; NbExp=5; IntAct=EBI-3939165, EBI-12843506;
CC O43711; Q96PV0: SYNGAP1; NbExp=3; IntAct=EBI-3939165, EBI-2682386;
CC O43711; Q9Y458: TBX22; NbExp=3; IntAct=EBI-3939165, EBI-6427217;
CC O43711; Q13488: TCIRG1; NbExp=3; IntAct=EBI-3939165, EBI-3914669;
CC O43711; Q96M29: TEKT5; NbExp=3; IntAct=EBI-3939165, EBI-10239812;
CC O43711; Q96LM6: TEX37; NbExp=3; IntAct=EBI-3939165, EBI-743976;
CC O43711; Q9BU02: THTPA; NbExp=3; IntAct=EBI-3939165, EBI-2820864;
CC O43711; Q69YG0: TMEM42; NbExp=3; IntAct=EBI-3939165, EBI-12038591;
CC O43711; Q96NM4-3: TOX2; NbExp=3; IntAct=EBI-3939165, EBI-12815137;
CC O43711; Q12888: TP53BP1; NbExp=3; IntAct=EBI-3939165, EBI-396540;
CC O43711; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-3939165, EBI-5235829;
CC O43711; Q6NVU6: UFSP1; NbExp=3; IntAct=EBI-3939165, EBI-12068150;
CC O43711; Q9BRX9: WDR83; NbExp=3; IntAct=EBI-3939165, EBI-7705033;
CC O43711; A0A0C4DGF1: ZBTB32; NbExp=3; IntAct=EBI-3939165, EBI-10188476;
CC O43711; M0R160: ZNF44; NbExp=3; IntAct=EBI-3939165, EBI-12945254;
CC O43711; G4XUV3; NbExp=3; IntAct=EBI-3939165, EBI-10177989;
CC O43711; P27577: Ets1; Xeno; NbExp=2; IntAct=EBI-3939165, EBI-4289053;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/TLX3ID398.html";
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DR EMBL; AJ223798; CAA11550.1; -; Genomic_DNA.
DR EMBL; AJ223799; CAA11550.1; JOINED; Genomic_DNA.
DR EMBL; AJ223800; CAA11550.1; JOINED; Genomic_DNA.
DR EMBL; BC017291; AAH17291.1; -; mRNA.
DR CCDS; CCDS34288.1; -.
DR RefSeq; NP_066305.2; NM_021025.3.
DR AlphaFoldDB; O43711; -.
DR SMR; O43711; -.
DR BioGRID; 119030; 259.
DR ELM; O43711; -.
DR IntAct; O43711; 246.
DR STRING; 9606.ENSP00000296921; -.
DR iPTMnet; O43711; -.
DR PhosphoSitePlus; O43711; -.
DR BioMuta; TLX3; -.
DR MassIVE; O43711; -.
DR PaxDb; O43711; -.
DR PeptideAtlas; O43711; -.
DR PRIDE; O43711; -.
DR ProteomicsDB; 49130; -.
DR Antibodypedia; 28858; 163 antibodies from 25 providers.
DR DNASU; 30012; -.
DR Ensembl; ENST00000296921.6; ENSP00000296921.5; ENSG00000164438.6.
DR GeneID; 30012; -.
DR KEGG; hsa:30012; -.
DR MANE-Select; ENST00000296921.6; ENSP00000296921.5; NM_021025.4; NP_066305.2.
DR UCSC; uc003mbf.3; human.
DR CTD; 30012; -.
DR DisGeNET; 30012; -.
DR GeneCards; TLX3; -.
DR HGNC; HGNC:13532; TLX3.
DR HPA; ENSG00000164438; Tissue enriched (brain).
DR MalaCards; TLX3; -.
DR MIM; 604640; gene.
DR neXtProt; NX_O43711; -.
DR OpenTargets; ENSG00000164438; -.
DR Orphanet; 99861; Precursor T-cell acute lymphoblastic leukemia.
DR PharmGKB; PA37797; -.
DR VEuPathDB; HostDB:ENSG00000164438; -.
DR eggNOG; KOG0488; Eukaryota.
DR GeneTree; ENSGT00940000160629; -.
DR HOGENOM; CLU_053409_1_0_1; -.
DR InParanoid; O43711; -.
DR OMA; TPHQHEP; -.
DR OrthoDB; 1391465at2759; -.
DR PhylomeDB; O43711; -.
DR TreeFam; TF325347; -.
DR PathwayCommons; O43711; -.
DR SignaLink; O43711; -.
DR SIGNOR; O43711; -.
DR BioGRID-ORCS; 30012; 14 hits in 1093 CRISPR screens.
DR ChiTaRS; TLX3; human.
DR GeneWiki; TLX3; -.
DR GenomeRNAi; 30012; -.
DR Pharos; O43711; Tbio.
DR PRO; PR:O43711; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; O43711; protein.
DR Bgee; ENSG00000164438; Expressed in right hemisphere of cerebellum and 20 other tissues.
DR Genevisible; O43711; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0048513; P:animal organ development; IBA:GO_Central.
DR GO; GO:0007417; P:central nervous system development; IEA:Ensembl.
DR GO; GO:0097154; P:GABAergic neuron differentiation; IEA:Ensembl.
DR GO; GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
DR GO; GO:0048665; P:neuron fate specification; IEA:Ensembl.
DR GO; GO:0001764; P:neuron migration; IEA:Ensembl.
DR GO; GO:0002087; P:regulation of respiratory gaseous exchange by nervous system process; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007585; P:respiratory gaseous exchange by respiratory system; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR042247; TLX1/2/3.
DR PANTHER; PTHR45921; PTHR45921; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..291
FT /note="T-cell leukemia homeobox protein 3"
FT /id="PRO_0000049338"
FT DNA_BIND 166..225
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 66
FT /note="L -> P (in Ref. 1; CAA11550)"
FT /evidence="ECO:0000305"
FT CONFLICT 122
FT /note="G -> R (in Ref. 1; CAA11550)"
FT /evidence="ECO:0000305"
FT CONFLICT 232..233
FT /note="ER -> DG (in Ref. 1; CAA11550)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 291 AA; 31867 MW; B5E3B910393EB4F3 CRC64;
MEAPASAQTP HPHEPISFGI DQILNSPDQD SAPAPRGPDG ASYLGGPPGG RPGATYPSLP
ASFAGLGAPF EDAGSYSVNL SLAPAGVIRV PAHRPLPGAV PPPLPSALPA MPSVPTVSSL
GGLNFPWMES SRRFVKDRFT AAAALTPFTV TRRIGHPYQN RTPPKRKKPR TSFSRVQICE
LEKRFHRQKY LASAERAALA KSLKMTDAQV KTWFQNRRTK WRRQTAEERE AERQQASRLM
LQLQHDAFQK SLNDSIQPDP LCLHNSSLFA LQNLQPWEED SSKVPAVTSL V
