TLX3_MOUSE
ID TLX3_MOUSE Reviewed; 291 AA.
AC O55144; Q5SQB4;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 16-OCT-2013, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=T-cell leukemia homeobox protein 3;
DE AltName: Full=Homeobox TLX-3;
DE AltName: Full=Homeobox protein Hox-11L2;
DE AltName: Full=Respiratory neuron homeobox protein;
GN Name=Tlx3; Synonyms=Hox11l2, Rnx, Tlx1l2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Delgado P., Rodriguez R., Gonzalez-Sarmiento R.;
RT "Genomic characterization of the human and mouse HOX11L2 genes.";
RL Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Spinal ganglion;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR EMBL; AJ223801; CAA11551.1; -; mRNA.
DR EMBL; AK141870; BAE24864.1; -; mRNA.
DR EMBL; AL772409; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466604; EDL23743.1; -; Genomic_DNA.
DR EMBL; BC141308; AAI41309.1; -; mRNA.
DR EMBL; BC145631; AAI45632.1; -; mRNA.
DR CCDS; CCDS24533.1; -.
DR RefSeq; NP_064300.2; NM_019916.2.
DR AlphaFoldDB; O55144; -.
DR SMR; O55144; -.
DR BioGRID; 205124; 34.
DR IntAct; O55144; 34.
DR STRING; 10090.ENSMUSP00000047457; -.
DR iPTMnet; O55144; -.
DR PhosphoSitePlus; O55144; -.
DR PaxDb; O55144; -.
DR PRIDE; O55144; -.
DR ProteomicsDB; 260670; -.
DR Antibodypedia; 28858; 163 antibodies from 25 providers.
DR DNASU; 27140; -.
DR Ensembl; ENSMUST00000037746; ENSMUSP00000047457; ENSMUSG00000040610.
DR GeneID; 27140; -.
DR KEGG; mmu:27140; -.
DR UCSC; uc007ikg.2; mouse.
DR CTD; 30012; -.
DR MGI; MGI:1351209; Tlx3.
DR VEuPathDB; HostDB:ENSMUSG00000040610; -.
DR eggNOG; KOG0488; Eukaryota.
DR GeneTree; ENSGT00940000160629; -.
DR HOGENOM; CLU_053409_1_0_1; -.
DR InParanoid; O55144; -.
DR OMA; TPHQHEP; -.
DR OrthoDB; 1391465at2759; -.
DR PhylomeDB; O55144; -.
DR TreeFam; TF325347; -.
DR BioGRID-ORCS; 27140; 3 hits in 76 CRISPR screens.
DR PRO; PR:O55144; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; O55144; protein.
DR Bgee; ENSMUSG00000040610; Expressed in lumbar dorsal root ganglion and 51 other tissues.
DR Genevisible; O55144; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0048513; P:animal organ development; IBA:GO_Central.
DR GO; GO:0007417; P:central nervous system development; IMP:MGI.
DR GO; GO:0097154; P:GABAergic neuron differentiation; IGI:MGI.
DR GO; GO:0045665; P:negative regulation of neuron differentiation; IGI:MGI.
DR GO; GO:0030182; P:neuron differentiation; IMP:MGI.
DR GO; GO:0048665; P:neuron fate specification; IMP:MGI.
DR GO; GO:0001764; P:neuron migration; IMP:MGI.
DR GO; GO:0002087; P:regulation of respiratory gaseous exchange by nervous system process; IMP:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007585; P:respiratory gaseous exchange by respiratory system; IMP:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR042247; TLX1/2/3.
DR PANTHER; PTHR45921; PTHR45921; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..291
FT /note="T-cell leukemia homeobox protein 3"
FT /id="PRO_0000049339"
FT DNA_BIND 166..225
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 232..233
FT /note="ER -> DG (in Ref. 1; CAA11551)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 291 AA; 31837 MW; A0E3B9103D2FA5E2 CRC64;
MEAPASAQTP HPHEPISFGI DQILNSPDQD SAPAPRGPDG ASYLGGPPGG RPGAAYPSLP
ASFAGLGAPF EDAGSYSVNL SLAPAGVIRV PAHRPLPGAV PPPLPSALPA MPSVPTVSSL
GGLNFPWMES SRRFVKDRFT AAAALTPFTV TRRIGHPYQN RTPPKRKKPR TSFSRVQICE
LEKRFHRQKY LASAERAALA KSLKMTDAQV KTWFQNRRTK WRRQTAEERE AERQQASRLM
LQLQHDAFQK SLNDSIQPDP LCLHNSSLFA LQNLQPWEED SSKVPAVTSL V
