ID   TM100_BOVIN             Reviewed;         134 AA.
AC   Q2KIC8;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Transmembrane protein 100;
GN   Name=TMEM100;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role during embryonic arterial endothelium
CC       differentiation and vascular morphogenesis through the ACVRL1 receptor-
CC       dependent signaling pathway upon stimulation by bone morphogenetic
CC       proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of
CC       nociception, acting as a modulator of the interaction between TRPA1 and
CC       TRPV1, two molecular sensors and mediators of pain signals in dorsal
CC       root ganglia (DRG) neurons. Mechanistically, it weakens their
CC       interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and
CC       increasing the single-channel open probability of the TRPA1-TRPV1
CC       complex. {ECO:0000250|UniProtKB:Q9CQG9}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with TRPA1 and TRPV1 (By
CC       similarity). Interacts with TASOR (By similarity).
CC       {ECO:0000250|UniProtKB:Q9CQG9}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9CQG9};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9CQG9}. Membrane
CC       {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Perikaryon
CC       {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Endoplasmic
CC       reticulum {ECO:0000250}. Note=Colocalized with HSPA5 in the endoplasmic
CC       reticulum (ER). Enriched in ER microsome. Colocalized with BMP4 in
CC       neural cell bodies and neural fibers of the enteric nervous system (By
CC       similarity). {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC112685; AAI12686.1; -; mRNA.
DR   RefSeq; NP_001039987.1; NM_001046522.2.
DR   RefSeq; XP_005219923.1; XM_005219866.3.
DR   RefSeq; XP_010813990.1; XM_010815688.2.
DR   AlphaFoldDB; Q2KIC8; -.
DR   STRING; 9913.ENSBTAP00000012241; -.
DR   PaxDb; Q2KIC8; -.
DR   Ensembl; ENSBTAT00000012241; ENSBTAP00000012241; ENSBTAG00000009292.
DR   GeneID; 613987; -.
DR   KEGG; bta:613987; -.
DR   CTD; 55273; -.
DR   VEuPathDB; HostDB:ENSBTAG00000009292; -.
DR   VGNC; VGNC:35941; TMEM100.
DR   eggNOG; ENOG502RZCB; Eukaryota.
DR   GeneTree; ENSGT00940000154322; -.
DR   HOGENOM; CLU_141108_0_0_1; -.
DR   InParanoid; Q2KIC8; -.
DR   OMA; CWKIRQH; -.
DR   OrthoDB; 1598239at2759; -.
DR   TreeFam; TF332068; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000009292; Expressed in lung and 97 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0060842; P:arterial endothelial cell differentiation; IEA:Ensembl.
DR   GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR   GO; GO:0071773; P:cellular response to BMP stimulus; IBA:GO_Central.
DR   GO; GO:0003198; P:epithelial to mesenchymal transition involved in endocardial cushion formation; IEA:Ensembl.
DR   GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:Ensembl.
DR   GO; GO:0045603; P:positive regulation of endothelial cell differentiation; IEA:Ensembl.
DR   GO; GO:2001214; P:positive regulation of vasculogenesis; IEA:Ensembl.
DR   GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
DR   GO; GO:0050848; P:regulation of calcium-mediated signaling; IEA:Ensembl.
DR   GO; GO:0051930; P:regulation of sensory perception of pain; ISS:UniProtKB.
DR   GO; GO:0001570; P:vasculogenesis; IEA:Ensembl.
DR   InterPro; IPR032536; TMEM100.
DR   PANTHER; PTHR16100:SF5; PTHR16100:SF5; 1.
DR   Pfam; PF16311; TMEM100; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Developmental protein; Differentiation;
KW   Endoplasmic reticulum; Membrane; Phosphoprotein; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..134
FT                   /note="Transmembrane protein 100"
FT                   /id="PRO_0000240845"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         15
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q569C0"
FT   MOD_RES         121
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9CQG9"
SQ   SEQUENCE   134 AA;  14341 MW;  F7C8ABFF0167B942 CRC64;
     MTDEPIKEIL GTPKSPKPVA MEKNANGEVV VTLVPLVSEI QLAAATGGAE LSCYRCVIPF
     AVVVLITGTV VTAVAYSFNS HGSIISILGL VLLSLGLFLL ASSALCWKVR QRSKKAKRRE
     SQTTLVVNQR GWFA