TM100_RAT
ID TM100_RAT Reviewed; 134 AA.
AC Q569C0;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Transmembrane protein 100;
GN Name=Tmem100;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15 AND SER-121, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Plays a role during embryonic arterial endothelium
CC differentiation and vascular morphogenesis through the ACVRL1 receptor-
CC dependent signaling pathway upon stimulation by bone morphogenetic
CC proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of
CC nociception, acting as a modulator of the interaction between TRPA1 and
CC TRPV1, two molecular sensors and mediators of pain signals in dorsal
CC root ganglia (DRG) neurons. Mechanistically, it weakens their
CC interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and
CC increasing the single-channel open probability of the TRPA1-TRPV1
CC complex. {ECO:0000250|UniProtKB:Q9CQG9}.
CC -!- SUBUNIT: Interacts (via C-terminus) with TRPA1 and TRPV1 (By
CC similarity). Interacts with TASOR (By similarity).
CC {ECO:0000250|UniProtKB:Q9CQG9}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9CQG9};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9CQG9}. Membrane
CC {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Perikaryon
CC {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Endoplasmic
CC reticulum {ECO:0000250}. Note=Colocalized with HSPA5 in the endoplasmic
CC reticulum (ER). Enriched in ER microsome. Colocalized with BMP4 in
CC neural cell bodies and neural fibers of the enteric nervous system (By
CC similarity). {ECO:0000250}.
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DR EMBL; BC092577; AAH92577.1; -; mRNA.
DR RefSeq; NP_001017479.1; NM_001017479.1.
DR RefSeq; XP_008766324.1; XM_008768102.2.
DR AlphaFoldDB; Q569C0; -.
DR STRING; 10116.ENSRNOP00000003297; -.
DR iPTMnet; Q569C0; -.
DR PhosphoSitePlus; Q569C0; -.
DR PaxDb; Q569C0; -.
DR PRIDE; Q569C0; -.
DR Ensembl; ENSRNOT00000003297; ENSRNOP00000003297; ENSRNOG00000002434.
DR Ensembl; ENSRNOT00000097540; ENSRNOP00000097274; ENSRNOG00000002434.
DR GeneID; 497979; -.
DR KEGG; rno:497979; -.
DR CTD; 55273; -.
DR RGD; 1560541; Tmem100.
DR eggNOG; ENOG502RZCB; Eukaryota.
DR GeneTree; ENSGT00940000154322; -.
DR HOGENOM; CLU_141108_0_0_1; -.
DR InParanoid; Q569C0; -.
DR OMA; CWKIRQH; -.
DR OrthoDB; 1598239at2759; -.
DR PhylomeDB; Q569C0; -.
DR TreeFam; TF332068; -.
DR PRO; PR:Q569C0; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000002434; Expressed in lung and 19 other tissues.
DR Genevisible; Q569C0; RN.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:RGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043204; C:perikaryon; ISO:RGD.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:RGD.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0001525; P:angiogenesis; ISO:RGD.
DR GO; GO:0060842; P:arterial endothelial cell differentiation; ISO:RGD.
DR GO; GO:0030509; P:BMP signaling pathway; ISO:RGD.
DR GO; GO:0071773; P:cellular response to BMP stimulus; ISO:RGD.
DR GO; GO:0003197; P:endocardial cushion development; ISO:RGD.
DR GO; GO:0003198; P:epithelial to mesenchymal transition involved in endocardial cushion formation; ISO:RGD.
DR GO; GO:0001701; P:in utero embryonic development; ISO:RGD.
DR GO; GO:0007219; P:Notch signaling pathway; ISO:RGD.
DR GO; GO:0045603; P:positive regulation of endothelial cell differentiation; ISO:RGD.
DR GO; GO:2001214; P:positive regulation of vasculogenesis; ISO:RGD.
DR GO; GO:0043491; P:protein kinase B signaling; ISO:RGD.
DR GO; GO:0050848; P:regulation of calcium-mediated signaling; ISO:RGD.
DR GO; GO:0051930; P:regulation of sensory perception of pain; ISS:UniProtKB.
DR GO; GO:0001570; P:vasculogenesis; ISO:RGD.
DR InterPro; IPR032536; TMEM100.
DR PANTHER; PTHR16100:SF5; PTHR16100:SF5; 1.
DR Pfam; PF16311; TMEM100; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cytoplasm; Developmental protein; Differentiation;
KW Endoplasmic reticulum; Membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..134
FT /note="Transmembrane protein 100"
FT /id="PRO_0000240848"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 15
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 121
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
SQ SEQUENCE 134 AA; 14352 MW; DB6481BE3194641F CRC64;
MTEEPTKENL GGPKSPTPVT MEKSPKSEVV VTTVPLVSEV QLTAATGGAE LSCYRCIIPF
AVVVFITGIV VTAVAYSFNS HGSVISILGL VLLSSGLFLL ASSALCWKVR QRNKKVKRRE
SQTALVVNQR SLFA
