ID   TM101_BOVIN             Reviewed;         257 AA.
AC   Q2KIB3;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Transmembrane protein 101;
GN   Name=TMEM101;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May activate NF-kappa-B signaling pathways. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; BC112701; AAI12702.1; -; mRNA.
DR   RefSeq; NP_001039667.1; NM_001046202.2.
DR   AlphaFoldDB; Q2KIB3; -.
DR   STRING; 9913.ENSBTAP00000021619; -.
DR   PaxDb; Q2KIB3; -.
DR   PRIDE; Q2KIB3; -.
DR   Ensembl; ENSBTAT00000021619; ENSBTAP00000021619; ENSBTAG00000016251.
DR   GeneID; 515507; -.
DR   KEGG; bta:515507; -.
DR   CTD; 84336; -.
DR   VEuPathDB; HostDB:ENSBTAG00000016251; -.
DR   VGNC; VGNC:35942; TMEM101.
DR   eggNOG; ENOG502QRKU; Eukaryota.
DR   GeneTree; ENSGT00390000011938; -.
DR   HOGENOM; CLU_094617_0_0_1; -.
DR   InParanoid; Q2KIB3; -.
DR   OMA; GGHVHYG; -.
DR   OrthoDB; 1351524at2759; -.
DR   TreeFam; TF332810; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000016251; Expressed in retina and 105 other tissues.
DR   ExpressionAtlas; Q2KIB3; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR029371; TMEM101.
DR   PANTHER; PTHR31034; PTHR31034; 1.
DR   Pfam; PF15111; TMEM101; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..257
FT                   /note="Transmembrane protein 101"
FT                   /id="PRO_0000240863"
FT   TRANSMEM        21..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        206..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        233..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   257 AA;  28683 MW;  F2477CA0BA92F23D CRC64;
     MASKTGSRRW MLQLIMQLGS VLLTRCPFWG CFSQLMLYAE RAEARRKPDI PVPYLYFDMG
     AAVLCASFMS FGVKRRWFAL GAALQLAIST YAAYVGGYVH YGDWLKVRMY SRTVAIIGGF
     LVLASGAGEL YRRKPRSRSL QSTGQVFLGV YLVCVAYSLQ HSKEDRLAYL NHLPGGELMV
     QLFFVLYGVL ALAFLSGYYV TLAAQILAVL LPPVMLLIDG NVAYWHNTRR VEFWNQMKLL
     GESVGIFGAA VILATDG