TM101_HUMAN
ID TM101_HUMAN Reviewed; 257 AA.
AC Q96IK0; B2R9N6;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Transmembrane protein 101;
DE AltName: Full=Putative NF-kappa-B-activating protein 130;
GN Name=TMEM101;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND FUNCTION.
RC TISSUE=Lung;
RX PubMed=12761501; DOI=10.1038/sj.onc.1206406;
RA Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y.,
RA Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.;
RT "Large-scale identification and characterization of human genes that
RT activate NF-kappaB and MAPK signaling pathways.";
RL Oncogene 22:3307-3318(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skeletal muscle;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: May activate NF-kappa-B signaling pathways.
CC {ECO:0000269|PubMed:12761501}.
CC -!- INTERACTION:
CC Q96IK0; Q12983: BNIP3; NbExp=3; IntAct=EBI-3922699, EBI-749464;
CC Q96IK0; Q8WVX3-2: C4orf3; NbExp=3; IntAct=EBI-3922699, EBI-12003442;
CC Q96IK0; Q8WWP7: GIMAP1; NbExp=3; IntAct=EBI-3922699, EBI-11991950;
CC Q96IK0; O95167: NDUFA3; NbExp=3; IntAct=EBI-3922699, EBI-1246131;
CC Q96IK0; Q9NZG7: NINJ2; NbExp=3; IntAct=EBI-3922699, EBI-10317425;
CC Q96IK0; Q13113: PDZK1IP1; NbExp=3; IntAct=EBI-3922699, EBI-716063;
CC Q96IK0; Q99640-2: PKMYT1; NbExp=3; IntAct=EBI-3922699, EBI-12257782;
CC Q96IK0; P0DN84: STRIT1; NbExp=3; IntAct=EBI-3922699, EBI-12200293;
CC Q96IK0; O60499-2: STX10; NbExp=3; IntAct=EBI-3922699, EBI-12094584;
CC Q96IK0; P57105: SYNJ2BP; NbExp=3; IntAct=EBI-3922699, EBI-1049004;
CC Q96IK0; Q9BU79: TMEM243; NbExp=3; IntAct=EBI-3922699, EBI-12887458;
CC Q96IK0; Q6PI78: TMEM65; NbExp=3; IntAct=EBI-3922699, EBI-6656213;
CC Q96IK0; P23763-3: VAMP1; NbExp=3; IntAct=EBI-3922699, EBI-12097582;
CC Q96IK0; P63027: VAMP2; NbExp=3; IntAct=EBI-3922699, EBI-520113;
CC Q96IK0; O95292: VAPB; NbExp=3; IntAct=EBI-3922699, EBI-1188298;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AB097008; BAC77361.1; -; mRNA.
DR EMBL; AK313855; BAG36583.1; -; mRNA.
DR EMBL; CH471178; EAW51642.1; -; Genomic_DNA.
DR EMBL; BC007438; AAH07438.1; -; mRNA.
DR CCDS; CCDS11474.1; -.
DR RefSeq; NP_001291742.1; NM_001304813.1.
DR RefSeq; NP_001291743.1; NM_001304814.1.
DR RefSeq; NP_115752.1; NM_032376.3.
DR RefSeq; XP_005257794.1; XM_005257737.2.
DR RefSeq; XP_011523648.1; XM_011525346.1.
DR RefSeq; XP_011523649.1; XM_011525347.1.
DR RefSeq; XP_011523651.1; XM_011525349.1.
DR RefSeq; XP_011523653.1; XM_011525351.1.
DR AlphaFoldDB; Q96IK0; -.
DR BioGRID; 124060; 28.
DR IntAct; Q96IK0; 20.
DR MINT; Q96IK0; -.
DR STRING; 9606.ENSP00000468025; -.
DR TCDB; 9.B.365.3.1; the putative 4 - 5 tms doxd (doxd) superfamily.
DR BioMuta; TMEM101; -.
DR DMDM; 74732068; -.
DR EPD; Q96IK0; -.
DR jPOST; Q96IK0; -.
DR MassIVE; Q96IK0; -.
DR MaxQB; Q96IK0; -.
DR PaxDb; Q96IK0; -.
DR PeptideAtlas; Q96IK0; -.
DR PRIDE; Q96IK0; -.
DR ProteomicsDB; 76835; -.
DR Antibodypedia; 54322; 71 antibodies from 20 providers.
DR DNASU; 84336; -.
DR Ensembl; ENST00000206380.8; ENSP00000206380.3; ENSG00000091947.10.
DR Ensembl; ENST00000589334.5; ENSP00000468025.1; ENSG00000091947.10.
DR GeneID; 84336; -.
DR KEGG; hsa:84336; -.
DR MANE-Select; ENST00000206380.8; ENSP00000206380.3; NM_032376.4; NP_115752.1.
DR UCSC; uc002ieu.4; human.
DR CTD; 84336; -.
DR GeneCards; TMEM101; -.
DR HGNC; HGNC:28653; TMEM101.
DR HPA; ENSG00000091947; Low tissue specificity.
DR neXtProt; NX_Q96IK0; -.
DR OpenTargets; ENSG00000091947; -.
DR PharmGKB; PA142670750; -.
DR VEuPathDB; HostDB:ENSG00000091947; -.
DR eggNOG; ENOG502QRKU; Eukaryota.
DR GeneTree; ENSGT00390000011938; -.
DR HOGENOM; CLU_094617_0_0_1; -.
DR InParanoid; Q96IK0; -.
DR OMA; GGHVHYG; -.
DR OrthoDB; 1351524at2759; -.
DR PhylomeDB; Q96IK0; -.
DR PathwayCommons; Q96IK0; -.
DR SignaLink; Q96IK0; -.
DR BioGRID-ORCS; 84336; 8 hits in 1083 CRISPR screens.
DR ChiTaRS; TMEM101; human.
DR GenomeRNAi; 84336; -.
DR Pharos; Q96IK0; Tdark.
DR PRO; PR:Q96IK0; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q96IK0; protein.
DR Bgee; ENSG00000091947; Expressed in metanephros cortex and 152 other tissues.
DR ExpressionAtlas; Q96IK0; baseline and differential.
DR Genevisible; Q96IK0; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; HMP:UniProtKB.
DR InterPro; IPR029371; TMEM101.
DR PANTHER; PTHR31034; PTHR31034; 1.
DR Pfam; PF15111; TMEM101; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..257
FT /note="Transmembrane protein 101"
FT /id="PRO_0000240864"
FT TRANSMEM 21..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 257 AA; 28795 MW; F2939392B69AFB2D CRC64;
MASKIGSRRW MLQLIMQLGS VLLTRCPFWG CFSQLMLYAE RAEARRKPDI PVPYLYFDMG
AAVLCASFMS FGVKRRWFAL GAALQLAIST YAAYIGGYVH YGDWLKVRMY SRTVAIIGGF
LVLASGAGEL YRRKPRSRSL QSTGQVFLGI YLICVAYSLQ HSKEDRLAYL NHLPGGELMI
QLFFVLYGIL ALAFLSGYYV TLAAQILAVL LPPVMLLIDG NVAYWHNTRR VEFWNQMKLL
GESVGIFGTA VILATDG
