TM101_MOUSE
ID TM101_MOUSE Reviewed; 257 AA.
AC Q91VP7; Q9CZW0;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Transmembrane protein 101;
GN Name=Tmem101;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Aorta, Corpora quadrigemina, Embryo, and Vein;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=NMRI; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May activate NF-kappa-B signaling pathways. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK012106; BAB28037.1; -; mRNA.
DR EMBL; AK041154; BAC30841.1; -; mRNA.
DR EMBL; AK049378; BAC33721.1; -; mRNA.
DR EMBL; AK140260; BAE24302.1; -; mRNA.
DR EMBL; BC011109; AAH11109.1; -; mRNA.
DR CCDS; CCDS25489.1; -.
DR RefSeq; NP_083925.2; NM_029649.2.
DR AlphaFoldDB; Q91VP7; -.
DR STRING; 10090.ENSMUSP00000021296; -.
DR EPD; Q91VP7; -.
DR MaxQB; Q91VP7; -.
DR PaxDb; Q91VP7; -.
DR PRIDE; Q91VP7; -.
DR ProteomicsDB; 259518; -.
DR Antibodypedia; 54322; 71 antibodies from 20 providers.
DR Ensembl; ENSMUST00000021296; ENSMUSP00000021296; ENSMUSG00000020921.
DR GeneID; 76547; -.
DR KEGG; mmu:76547; -.
DR UCSC; uc007lqr.2; mouse.
DR CTD; 84336; -.
DR MGI; MGI:1923797; Tmem101.
DR VEuPathDB; HostDB:ENSMUSG00000020921; -.
DR eggNOG; ENOG502QRKU; Eukaryota.
DR GeneTree; ENSGT00390000011938; -.
DR HOGENOM; CLU_094617_0_0_1; -.
DR InParanoid; Q91VP7; -.
DR OMA; GGHVHYG; -.
DR OrthoDB; 1351524at2759; -.
DR PhylomeDB; Q91VP7; -.
DR TreeFam; TF332810; -.
DR BioGRID-ORCS; 76547; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q91VP7; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q91VP7; protein.
DR Bgee; ENSMUSG00000020921; Expressed in floor plate of midbrain and 249 other tissues.
DR Genevisible; Q91VP7; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR029371; TMEM101.
DR PANTHER; PTHR31034; PTHR31034; 1.
DR Pfam; PF15111; TMEM101; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..257
FT /note="Transmembrane protein 101"
FT /id="PRO_0000240865"
FT TRANSMEM 24..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 12
FT /note="L -> P (in Ref. 1; BAB28037)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 257 AA; 28783 MW; 84FB27B43A6C775A CRC64;
MASKIGSRRW MLQLIMQLGS VLLTRCPFWG CFSQLMLYAE RAEARRKPDI PVPYLYFDMG
AAVLCASFMS FGVKRRWFAL GAALQLAIST YTAYIGGYVH YGDWLKVRMY SRTVAIIGGF
LVLASGAGEL YRRKPRSRSL QSTGQVFLGI YLICVAYSLQ HSKEDRLAYL NHLPGGELMV
QLFFVLYGVL ALAFLSGYYV TLAAQILAVL LPPVMLLIDG NVSYWHNTRR VEFWNQMKLL
GESVGIFGAA VILATDG
