ID   TM101_PONAB             Reviewed;         257 AA.
AC   Q5RFN8;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Transmembrane protein 101;
GN   Name=TMEM101;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May activate NF-kappa-B signaling pathways. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; CR857115; CAH89419.1; -; mRNA.
DR   RefSeq; NP_001127144.1; NM_001133672.1.
DR   AlphaFoldDB; Q5RFN8; -.
DR   STRING; 9601.ENSPPYP00000009382; -.
DR   Ensembl; ENSPPYT00000039943; ENSPPYP00000039658; ENSPPYG00000031052.
DR   GeneID; 100174195; -.
DR   KEGG; pon:100174195; -.
DR   CTD; 84336; -.
DR   eggNOG; ENOG502QRKU; Eukaryota.
DR   GeneTree; ENSGT00390000011938; -.
DR   HOGENOM; CLU_094617_0_0_1; -.
DR   InParanoid; Q5RFN8; -.
DR   OMA; GGHVHYG; -.
DR   OrthoDB; 1351524at2759; -.
DR   TreeFam; TF332810; -.
DR   Proteomes; UP000001595; Chromosome 17.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR029371; TMEM101.
DR   PANTHER; PTHR31034; PTHR31034; 1.
DR   Pfam; PF15111; TMEM101; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..257
FT                   /note="Transmembrane protein 101"
FT                   /id="PRO_0000240866"
FT   TRANSMEM        21..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        206..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        233..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   257 AA;  28781 MW;  29309392A4186B3F CRC64;
     MASKIGSRRW MLQLIMQLGS VLLTRCPFWG CFSQLMLYAE RAEARRKPDI PVPYLYFDMG
     AAVLCASFMS FGVKRRWFAL GAALQLAIST YAAYIGGYVH YGDWLKVRMY SRTVAIIGGF
     LVLASGAGEL YRRKPRSRSL QSTGQVFLGI YLICVAYSLQ HSKEDRLAYL NHLPGGELMI
     QLFFVLYGVL ALAFLSGYYV TLAAQILAVL LPPVMLLIDG NVAYWHNTRR VEFWNQMKLL
     GESVGIFGTA VILATDG