TM102_BOVIN
ID TM102_BOVIN Reviewed; 512 AA.
AC Q1LZD1;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Transmembrane protein 102;
GN Name=TMEM102;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Ascending colon;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Selectively involved in CSF2 deprivation-induced apoptosis
CC via a mitochondria-dependent pathway. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CSF2RB; this interaction occurs preferentially
CC in the absence of CSF2. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane
CC protein {ECO:0000250}. Note=Also located in intracellular compartments.
CC {ECO:0000250}.
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DR EMBL; BC116075; AAI16076.1; -; mRNA.
DR RefSeq; NP_001068812.1; NM_001075344.1.
DR RefSeq; XP_005220257.1; XM_005220200.3.
DR RefSeq; XP_010814202.1; XM_010815900.2.
DR AlphaFoldDB; Q1LZD1; -.
DR SMR; Q1LZD1; -.
DR STRING; 9913.ENSBTAP00000025621; -.
DR PaxDb; Q1LZD1; -.
DR PRIDE; Q1LZD1; -.
DR Ensembl; ENSBTAT00000025621; ENSBTAP00000025621; ENSBTAG00000031737.
DR Ensembl; ENSBTAT00000078110; ENSBTAP00000063464; ENSBTAG00000031737.
DR GeneID; 508014; -.
DR KEGG; bta:508014; -.
DR CTD; 284114; -.
DR VEuPathDB; HostDB:ENSBTAG00000031737; -.
DR VGNC; VGNC:35943; TMEM102.
DR eggNOG; KOG3963; Eukaryota.
DR GeneTree; ENSGT01050000244976; -.
DR HOGENOM; CLU_041150_0_0_1; -.
DR InParanoid; Q1LZD1; -.
DR OMA; HYFLSGR; -.
DR OrthoDB; 418799at2759; -.
DR TreeFam; TF329089; -.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000031737; Expressed in digestive system secreted substance and 75 other tissues.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0045785; P:positive regulation of cell adhesion; IEA:Ensembl.
DR GO; GO:0010820; P:positive regulation of T cell chemotaxis; IEA:Ensembl.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR GO; GO:1901028; P:regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
DR GO; GO:0034097; P:response to cytokine; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:Ensembl.
DR InterPro; IPR024810; Mab-21_dom.
DR InterPro; IPR024806; TMEM102.
DR PANTHER; PTHR10656:SF48; PTHR10656:SF48; 1.
DR Pfam; PF03281; Mab-21; 1.
DR SMART; SM01265; Mab-21; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..512
FT /note="Transmembrane protein 102"
FT /id="PRO_0000263647"
FT TOPO_DOM 1..267
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..284
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 285..512
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 168..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 512 AA; 54641 MW; AC21A0704F1156BF CRC64;
MASAVWGNAP WWSPPPPAPA RPLTDIDFCS GAQLQELTQL IQELGVQESW NDGPKPGPDL
LQAKDFVFSL LSLIHRRDPR FPPQTELLLL RGGIREGSLD LGPAPLGPYT RGPHYDAGFT
LLVPVFSLDG TGQELQLDMR SCYAWLCLPE QVRGTSVREA WQDCLGPPVP GGRDWIHPTD
SREGPRDPQS SVDQPHSDII EPEAHESLEK SPSNVSVPES PQQNLTDIGF PSLSEETNDD
VTKAADVSPG PQPSEAREAW PTLCPAQVAA WFFASLAAVA ESLFPVPGAP RLVHAARHAG
FTTILLATPG PPRRLLLFDL IPVVSVAGWP QGARSHSWAG PLASESSSFY LVPGGGGQTE
RPGASGWQLC FARQELALKA RIPTPLLQAH AAAQALLRPL VAGTRAAAPY LLRTLLYWAC
ERLPALYLAR PENAGACCLG LLDELGRVLE ARTLPHYFLS GQKLRAGDGA SSLLGALALL
RGDPARALRA AVEEAKAARK GGGLAGVGAG SH