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TM102_BOVIN
ID   TM102_BOVIN             Reviewed;         512 AA.
AC   Q1LZD1;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Transmembrane protein 102;
GN   Name=TMEM102;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Selectively involved in CSF2 deprivation-induced apoptosis
CC       via a mitochondria-dependent pathway. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CSF2RB; this interaction occurs preferentially
CC       in the absence of CSF2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane
CC       protein {ECO:0000250}. Note=Also located in intracellular compartments.
CC       {ECO:0000250}.
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DR   EMBL; BC116075; AAI16076.1; -; mRNA.
DR   RefSeq; NP_001068812.1; NM_001075344.1.
DR   RefSeq; XP_005220257.1; XM_005220200.3.
DR   RefSeq; XP_010814202.1; XM_010815900.2.
DR   AlphaFoldDB; Q1LZD1; -.
DR   SMR; Q1LZD1; -.
DR   STRING; 9913.ENSBTAP00000025621; -.
DR   PaxDb; Q1LZD1; -.
DR   PRIDE; Q1LZD1; -.
DR   Ensembl; ENSBTAT00000025621; ENSBTAP00000025621; ENSBTAG00000031737.
DR   Ensembl; ENSBTAT00000078110; ENSBTAP00000063464; ENSBTAG00000031737.
DR   GeneID; 508014; -.
DR   KEGG; bta:508014; -.
DR   CTD; 284114; -.
DR   VEuPathDB; HostDB:ENSBTAG00000031737; -.
DR   VGNC; VGNC:35943; TMEM102.
DR   eggNOG; KOG3963; Eukaryota.
DR   GeneTree; ENSGT01050000244976; -.
DR   HOGENOM; CLU_041150_0_0_1; -.
DR   InParanoid; Q1LZD1; -.
DR   OMA; HYFLSGR; -.
DR   OrthoDB; 418799at2759; -.
DR   TreeFam; TF329089; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000031737; Expressed in digestive system secreted substance and 75 other tissues.
DR   GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0045785; P:positive regulation of cell adhesion; IEA:Ensembl.
DR   GO; GO:0010820; P:positive regulation of T cell chemotaxis; IEA:Ensembl.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   GO; GO:1901028; P:regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; IEA:Ensembl.
DR   GO; GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
DR   GO; GO:0034097; P:response to cytokine; IEA:Ensembl.
DR   GO; GO:0007165; P:signal transduction; IEA:Ensembl.
DR   InterPro; IPR024810; Mab-21_dom.
DR   InterPro; IPR024806; TMEM102.
DR   PANTHER; PTHR10656:SF48; PTHR10656:SF48; 1.
DR   Pfam; PF03281; Mab-21; 1.
DR   SMART; SM01265; Mab-21; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..512
FT                   /note="Transmembrane protein 102"
FT                   /id="PRO_0000263647"
FT   TOPO_DOM        1..267
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..284
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        285..512
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          168..258
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        209..238
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   512 AA;  54641 MW;  AC21A0704F1156BF CRC64;
     MASAVWGNAP WWSPPPPAPA RPLTDIDFCS GAQLQELTQL IQELGVQESW NDGPKPGPDL
     LQAKDFVFSL LSLIHRRDPR FPPQTELLLL RGGIREGSLD LGPAPLGPYT RGPHYDAGFT
     LLVPVFSLDG TGQELQLDMR SCYAWLCLPE QVRGTSVREA WQDCLGPPVP GGRDWIHPTD
     SREGPRDPQS SVDQPHSDII EPEAHESLEK SPSNVSVPES PQQNLTDIGF PSLSEETNDD
     VTKAADVSPG PQPSEAREAW PTLCPAQVAA WFFASLAAVA ESLFPVPGAP RLVHAARHAG
     FTTILLATPG PPRRLLLFDL IPVVSVAGWP QGARSHSWAG PLASESSSFY LVPGGGGQTE
     RPGASGWQLC FARQELALKA RIPTPLLQAH AAAQALLRPL VAGTRAAAPY LLRTLLYWAC
     ERLPALYLAR PENAGACCLG LLDELGRVLE ARTLPHYFLS GQKLRAGDGA SSLLGALALL
     RGDPARALRA AVEEAKAARK GGGLAGVGAG SH
 
 
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