TM102_HUMAN
ID TM102_HUMAN Reviewed; 508 AA.
AC Q8N9M5; D3DTP8;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Transmembrane protein 102;
DE AltName: Full=Common beta-chain associated protein;
DE Short=CBAP;
GN Name=TMEM102;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Glial tumor;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, INTERACTION WITH CSF2RB, SUBCELLULAR LOCATION, AND TOPOLOGY.
RX PubMed=17828305; DOI=10.1038/sj.onc.1210778;
RA Kao C.J., Chiang Y.J., Chen P.H., Lin K.R., Hwang P.I., Yang-Yen H.F.,
RA Yen J.J.;
RT "CBAP interacts with the un-liganded common beta-subunit of the GM-CSF/IL-
RT 3/IL-5 receptor and induces apoptosis via mitochondrial dysfunction.";
RL Oncogene 27:1397-1403(2008).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: Selectively involved in CSF2 deprivation-induced apoptosis
CC via a mitochondria-dependent pathway. {ECO:0000269|PubMed:17828305}.
CC -!- SUBUNIT: Interacts with CSF2RB; this interaction occurs preferentially
CC in the absence of CSF2. {ECO:0000269|PubMed:17828305}.
CC -!- INTERACTION:
CC Q8N9M5; Q9UP95: SLC12A4; NbExp=3; IntAct=EBI-1050459, EBI-7244836;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17828305};
CC Single-pass membrane protein {ECO:0000269|PubMed:17828305}.
CC Note=Although it is found at the cell surface, the majority of the
CC molecules seems to be located in intracellular compartments.
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DR EMBL; AK094197; BAC04306.1; -; mRNA.
DR EMBL; CH471108; EAW90189.1; -; Genomic_DNA.
DR EMBL; CH471108; EAW90190.1; -; Genomic_DNA.
DR EMBL; BC046189; AAH46189.1; -; mRNA.
DR CCDS; CCDS11104.1; -.
DR RefSeq; NP_001307373.1; NM_001320444.1.
DR RefSeq; NP_848613.1; NM_178518.2.
DR AlphaFoldDB; Q8N9M5; -.
DR SMR; Q8N9M5; -.
DR BioGRID; 129765; 21.
DR IntAct; Q8N9M5; 7.
DR MINT; Q8N9M5; -.
DR STRING; 9606.ENSP00000315387; -.
DR iPTMnet; Q8N9M5; -.
DR PhosphoSitePlus; Q8N9M5; -.
DR BioMuta; TMEM102; -.
DR DMDM; 74729725; -.
DR EPD; Q8N9M5; -.
DR jPOST; Q8N9M5; -.
DR MassIVE; Q8N9M5; -.
DR MaxQB; Q8N9M5; -.
DR PaxDb; Q8N9M5; -.
DR PeptideAtlas; Q8N9M5; -.
DR PRIDE; Q8N9M5; -.
DR ProteomicsDB; 72560; -.
DR Antibodypedia; 11967; 82 antibodies from 20 providers.
DR DNASU; 284114; -.
DR Ensembl; ENST00000323206.2; ENSP00000315387.1; ENSG00000181284.3.
DR Ensembl; ENST00000396568.1; ENSP00000379815.1; ENSG00000181284.3.
DR Ensembl; ENST00000638427.2; ENSP00000491063.1; ENSG00000284228.2.
DR Ensembl; ENST00000639387.1; ENSP00000491290.1; ENSG00000284228.2.
DR GeneID; 284114; -.
DR KEGG; hsa:284114; -.
DR MANE-Select; ENST00000323206.2; ENSP00000315387.1; NM_178518.3; NP_848613.1.
DR UCSC; uc002ggx.1; human.
DR CTD; 284114; -.
DR DisGeNET; 284114; -.
DR GeneCards; TMEM102; -.
DR HGNC; HGNC:26722; TMEM102.
DR HPA; ENSG00000181284; Low tissue specificity.
DR MIM; 613936; gene.
DR neXtProt; NX_Q8N9M5; -.
DR OpenTargets; ENSG00000181284; -.
DR PharmGKB; PA142670751; -.
DR VEuPathDB; HostDB:ENSG00000181284; -.
DR eggNOG; KOG3963; Eukaryota.
DR GeneTree; ENSGT01050000244976; -.
DR HOGENOM; CLU_041150_0_0_1; -.
DR InParanoid; Q8N9M5; -.
DR OMA; HYFLSGR; -.
DR OrthoDB; 418799at2759; -.
DR PhylomeDB; Q8N9M5; -.
DR TreeFam; TF329089; -.
DR PathwayCommons; Q8N9M5; -.
DR SignaLink; Q8N9M5; -.
DR BioGRID-ORCS; 284114; 11 hits in 1082 CRISPR screens.
DR ChiTaRS; TMEM102; human.
DR GenomeRNAi; 284114; -.
DR Pharos; Q8N9M5; Tbio.
DR PRO; PR:Q8N9M5; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q8N9M5; protein.
DR Bgee; ENSG00000181284; Expressed in mucosa of transverse colon and 88 other tissues.
DR Genevisible; Q8N9M5; HS.
DR GO; GO:0009986; C:cell surface; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032991; C:protein-containing complex; IDA:MGI.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0045785; P:positive regulation of cell adhesion; IDA:MGI.
DR GO; GO:0010820; P:positive regulation of T cell chemotaxis; IEA:Ensembl.
DR GO; GO:2000406; P:positive regulation of T cell migration; IDA:MGI.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR GO; GO:1901028; P:regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; IDA:UniProtKB.
DR GO; GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
DR GO; GO:0034097; P:response to cytokine; IDA:UniProtKB.
DR GO; GO:0007165; P:signal transduction; IDA:UniProtKB.
DR InterPro; IPR024810; Mab-21_dom.
DR InterPro; IPR024806; TMEM102.
DR PANTHER; PTHR10656:SF48; PTHR10656:SF48; 1.
DR Pfam; PF03281; Mab-21; 1.
DR SMART; SM01265; Mab-21; 1.
PE 1: Evidence at protein level;
KW Apoptosis; Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..508
FT /note="Transmembrane protein 102"
FT /id="PRO_0000263648"
FT TOPO_DOM 1..260
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 261..278
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 279..508
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 170..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..187
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 110
FT /note="A -> V (in dbSNP:rs3809718)"
FT /id="VAR_029595"
SQ SEQUENCE 508 AA; 54175 MW; 27B3FDC1C30E3406 CRC64;
MASAVWGSAP WWGPPPPAPA RPLTDIDFCS GAQLQELTQL IQELGVQESW SDGPKPGADL
LRAKDFVFSL LGLVHRRDPR FPPQAELLLL RGGIREGSLD LGHAPLGPYA RGPHYDAGFT
LLVPMFSLDG TELQLDLESC YAQVCLPEMV CGTPIREMWQ DCLGPPVPGA RDSIHRTESE
ESSKDWQSSV DQPHSYVTEH EAPVSLEKSP SDVSASESPQ HDVVDLGSTA PLKTMSSDVT
KAAVESPVPK PSEAREAWPT LCSAQVAAWF FATLAAVAES LIPVPGAPRL VHAARHAGFT
TVLLATPEPP RRLLLFDLIP VVSVAGWPEG ARSHSWAGPL ASESASFYLV PGGGTERPCA
SAWQLCFARQ ELALKARIPA PLLQAHAAAQ ALLRPLVAGT RAAAPYLLRT LLYWACERLP
ALYLARPENA GACCLGLLDE LGRVLEAGTL PHYFLNGRQL RTGDDSAALL GELARLRGDP
ARALRAAVEE AKVARKGGGL AGVGGGAH
