TM102_MOUSE
ID TM102_MOUSE Reviewed; 509 AA.
AC Q3UPR7; E9Q2B4;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Transmembrane protein 102;
GN Name=Tmem102;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Oviduct;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Selectively involved in CSF2 deprivation-induced apoptosis
CC via a mitochondria-dependent pathway. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CSF2RB; this interaction occurs preferentially
CC in the absence of CSF2. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane
CC protein {ECO:0000250}. Note=Also located in intracellular compartments.
CC {ECO:0000250}.
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DR EMBL; AK143262; BAE25328.1; -; mRNA.
DR EMBL; AL603707; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS36198.1; -.
DR RefSeq; NP_001028605.2; NM_001033433.4.
DR AlphaFoldDB; Q3UPR7; -.
DR SMR; Q3UPR7; -.
DR IntAct; Q3UPR7; 1.
DR STRING; 10090.ENSMUSP00000132164; -.
DR iPTMnet; Q3UPR7; -.
DR PhosphoSitePlus; Q3UPR7; -.
DR MaxQB; Q3UPR7; -.
DR PaxDb; Q3UPR7; -.
DR PRIDE; Q3UPR7; -.
DR ProteomicsDB; 258898; -.
DR Antibodypedia; 11967; 82 antibodies from 20 providers.
DR Ensembl; ENSMUST00000051025; ENSMUSP00000132164; ENSMUSG00000089876.
DR GeneID; 380705; -.
DR KEGG; mmu:380705; -.
DR UCSC; uc007jrs.2; mouse.
DR CTD; 284114; -.
DR MGI; MGI:1921591; Tmem102.
DR VEuPathDB; HostDB:ENSMUSG00000089876; -.
DR eggNOG; KOG3963; Eukaryota.
DR GeneTree; ENSGT01050000244976; -.
DR HOGENOM; CLU_041150_0_0_1; -.
DR InParanoid; Q3UPR7; -.
DR OMA; HYFLSGR; -.
DR OrthoDB; 418799at2759; -.
DR PhylomeDB; Q3UPR7; -.
DR TreeFam; TF329089; -.
DR BioGRID-ORCS; 380705; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q3UPR7; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q3UPR7; protein.
DR Bgee; ENSMUSG00000089876; Expressed in lip and 48 other tissues.
DR Genevisible; Q3UPR7; MM.
DR GO; GO:0009986; C:cell surface; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032991; C:protein-containing complex; ISO:MGI.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0045785; P:positive regulation of cell adhesion; IDA:MGI.
DR GO; GO:0010820; P:positive regulation of T cell chemotaxis; IMP:MGI.
DR GO; GO:2000406; P:positive regulation of T cell migration; IDA:MGI.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR GO; GO:1901028; P:regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; ISO:MGI.
DR GO; GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation; IMP:MGI.
DR GO; GO:0034097; P:response to cytokine; ISO:MGI.
DR GO; GO:0007165; P:signal transduction; ISO:MGI.
DR InterPro; IPR024810; Mab-21_dom.
DR InterPro; IPR024806; TMEM102.
DR PANTHER; PTHR10656:SF48; PTHR10656:SF48; 1.
DR Pfam; PF03281; Mab-21; 1.
DR SMART; SM01265; Mab-21; 1.
PE 1: Evidence at protein level;
KW Apoptosis; Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..509
FT /note="Transmembrane protein 102"
FT /id="PRO_0000263649"
FT TOPO_DOM 1..312
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 313..329
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 330..509
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 167..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..200
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 64
FT /note="K -> E (in Ref. 1; BAE25328)"
FT /evidence="ECO:0000305"
FT CONFLICT 88
FT /note="L -> V (in Ref. 1; BAE25328)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 509 AA; 54923 MW; D090666DE920B01D CRC64;
MASTVWGGAP WWGPPPPAPA RPLTDIDFCS GAQLQELTQL IQELRVQESW SEGPKPGADL
LRAKDFVFAL LGLVHRQDPR FPPQAELLLL RGGIREGSLD LGHAPLGPYS RGPHYDAGFT
LLVPVFSLDG TGPELLLDLE SCSAWLRLPE LMRGILVREA WQDCLGPPVP EESDMTHQTH
SKESPTDREN SVDPSHDYVP EPEPHMSLQK SSSDLSESQS SYKDITNPET PEPLETLSSD
ALDADESQVP KPSEAPKAWP TLCPTQVTSW FFVKLAEVAE SLIPVPGAPR LVHAARHAGV
TTVLLATPEP PRHLLLFDLI PVVTVTGWPD TARSHSWAGP LVSESASFYL VPGSLPEQPS
TSGWQLCFAR QELALKERIP TPLLQAHAAA QALLRPLVAG TRAAAPYLLR TLLYWACERL
PALYLARPEN AGACCLGLLD ELSRVLEAGA LPHYFLSGRK LRVGDGSAAL RGALAQLRGD
PAQALREAVE EAKVARKGGG LAGVGGGTH
