ID   TM104_CAEBR             Reviewed;         492 AA.
AC   Q610N4; A8XQY5;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 2.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Transmembrane protein 104 homolog;
GN   ORFNames=CBG17386;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM104 family. {ECO:0000305}.
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DR   EMBL; HE600924; CAP35060.2; -; Genomic_DNA.
DR   AlphaFoldDB; Q610N4; -.
DR   STRING; 6238.CBG17386; -.
DR   WormBase; CBG17386; CBP41580; WBGene00037029; -.
DR   eggNOG; KOG3832; Eukaryota.
DR   HOGENOM; CLU_025541_1_0_1; -.
DR   InParanoid; Q610N4; -.
DR   OMA; DVVCDQT; -.
DR   OrthoDB; 789592at2759; -.
DR   Proteomes; UP000008549; Chromosome X.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR013057; AA_transpt_TM.
DR   Pfam; PF01490; Aa_trans; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..492
FT                   /note="Transmembrane protein 104 homolog"
FT                   /id="PRO_0000254183"
FT   TOPO_DOM        1..18
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        40..45
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        67..114
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        136..177
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        199..210
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        232..238
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..275
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        297..325
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        326..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        347..391
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        392..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        413..415
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        416..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        437..466
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        467..487
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        488..492
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          367..387
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        152
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        314
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   492 AA;  54104 MW;  3D7C3DD4B24BF095 CRC64;
     MQSNTDSSGT SGTYSQTVGL LYVFNLIVGT GALALPKAFQ SAGWLLSISL LTFSAFMSYV
     AATFVIEALS VANAVLSKKR RVEYDDVVVA DGPSTFEIAK KVEVSEMASM FLSKVSLVFS
     YFAIIIYLFG DLAIYSTTVP KSAMNIVCST INATIVKSSD PCHESWPEIL TRMTVYRFFV
     IVFVVVVCLP MVIAGITKTR HIQIMTTLSR WAAFILMISL ATMQLSSQGA AAHPPAYNFH
     GFGSLFGCAV YAFMCHHSIP SLITPMRTKE NVFGKIAVVY GIVGVFYFTL SLTGAFAFEH
     VQDIYTLNFL HDDNTSLVYS IIDYFLALFP IITLTSSYPI IALTLINNFK VVKDILCPKT
     GQENESLLEA DNQVEDNDTD DEREARNGNP KTIFDVLVPT LVLALPTFLS LLTDDMLLLA
     SITGSFPGVA VQFAIPCLLV TAARKHARSV LNFPVPRKNN SPFQSRFWIM LISSWAGFSM
     IMVLLNLVGV KF