TM104_CAEEL
ID TM104_CAEEL Reviewed; 492 AA.
AC Q17598;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Transmembrane protein 104 homolog;
GN ORFNames=C03A3.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-151, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC STRAIN=Bristol N2;
RX PubMed=17761667; DOI=10.1074/mcp.m600392-mcp200;
RA Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T.,
RA Taoka M., Takahashi N., Isobe T.;
RT "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis
RT elegans and suggests an atypical translocation mechanism for integral
RT membrane proteins.";
RL Mol. Cell. Proteomics 6:2100-2109(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM104 family. {ECO:0000305}.
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DR EMBL; Z73423; CAA97776.2; -; Genomic_DNA.
DR PIR; T18871; T18871.
DR RefSeq; NP_509879.2; NM_077478.5.
DR AlphaFoldDB; Q17598; -.
DR BioGRID; 46225; 2.
DR IntAct; Q17598; 2.
DR STRING; 6239.C03A3.2; -.
DR iPTMnet; Q17598; -.
DR EPD; Q17598; -.
DR PaxDb; Q17598; -.
DR PeptideAtlas; Q17598; -.
DR EnsemblMetazoa; C03A3.2.1; C03A3.2.1; WBGene00007267.
DR GeneID; 181315; -.
DR KEGG; cel:CELE_C03A3.2; -.
DR UCSC; C03A3.2.1; c. elegans.
DR CTD; 181315; -.
DR WormBase; C03A3.2; CE31404; WBGene00007267; -.
DR eggNOG; KOG3832; Eukaryota.
DR GeneTree; ENSGT00390000001244; -.
DR HOGENOM; CLU_025541_1_0_1; -.
DR InParanoid; Q17598; -.
DR OMA; DVVCDQT; -.
DR OrthoDB; 789592at2759; -.
DR PhylomeDB; Q17598; -.
DR PRO; PR:Q17598; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00007267; Expressed in larva and 4 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR013057; AA_transpt_TM.
DR Pfam; PF01490; Aa_trans; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..492
FT /note="Transmembrane protein 104 homolog"
FT /id="PRO_0000254184"
FT TOPO_DOM 1..17
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 39..44
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 66..113
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 135..176
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 198..209
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 231..237
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..274
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..324
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 325..345
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 346..392
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 393..413
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 414..415
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 416..436
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 437..466
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 467..487
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 488..492
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT CARBOHYD 151
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
FT CARBOHYD 313
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 492 AA; 54021 MW; D6376124C0FF8F9F CRC64;
MQSNTDSSTS GTYSQTVGLL YVFNLIVGTG ALALPKAFQT AGWLLSITLL TFSAFMSYVA
ATFVIEALSV ANAVLSKKRR VEYDDVVVAD GPSTFEISKK VEVSEMASMF LSKVSLVFSY
FAIIIYLFGD LAIYSTTVPK SAMNIVCATI NASTVKSSDP CHESWPEILT RMTVYRFFVI
IFVVVVCLPM VIAGITKTRH IQIMTTLSRW AAFILMISLA TMQLSSDGAA AHPPAYNFHG
FGSLFGCAVY AFMCHHSIPS LITPMRTKDN VFGKIALVYG VVGVFYFTLS LTGAFAFEHV
QDIYTLNFFH DGNTSFIYSI IDYFLALFPI ITLTSSYPII ALTLINNFNV VKDILCPKVG
QENESLLEAD SLVEDNDTDD EREARNARNE KSVFDVLVPA LVLALPTFLS LLTDDMLLLA
SITGSFPGVA VQFAIPCLLV TAARKHARSV LNFPVPRKNN SPFQSPIWIV LISSWAGFSM
IMVLLNLVGV KF
