TM104_HUMAN
ID TM104_HUMAN Reviewed; 496 AA.
AC Q8NE00; Q8TEU1; Q9NT56; Q9NXH1;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Transmembrane protein 104;
GN Name=TMEM104;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP MET-58.
RC TISSUE=Colon mucosa, and Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT MET-58.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 243-496 (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
RT "Global, in vivo, and site-specific phosphorylation dynamics in signaling
RT networks.";
RL Cell 127:635-648(2006).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8NE00-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NE00-2; Sequence=VSP_021199, VSP_021200;
CC -!- SIMILARITY: Belongs to the TMEM104 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB84855.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK000262; BAA91039.1; -; mRNA.
DR EMBL; AK074029; BAB84855.1; ALT_INIT; mRNA.
DR EMBL; BC037278; AAH37278.1; -; mRNA.
DR EMBL; AL137521; CAB70787.1; -; mRNA.
DR CCDS; CCDS32723.1; -. [Q8NE00-1]
DR CCDS; CCDS82201.1; -. [Q8NE00-2]
DR PIR; T46367; T46367.
DR RefSeq; NP_001308193.1; NM_001321264.1. [Q8NE00-2]
DR RefSeq; NP_060198.3; NM_017728.3. [Q8NE00-1]
DR AlphaFoldDB; Q8NE00; -.
DR BioGRID; 120217; 7.
DR IntAct; Q8NE00; 3.
DR STRING; 9606.ENSP00000334849; -.
DR TCDB; 2.A.18.10.1; the amino acid/auxin permease (aaap) family.
DR GlyGen; Q8NE00; 1 site.
DR iPTMnet; Q8NE00; -.
DR PhosphoSitePlus; Q8NE00; -.
DR BioMuta; TMEM104; -.
DR DMDM; 117949798; -.
DR EPD; Q8NE00; -.
DR jPOST; Q8NE00; -.
DR MassIVE; Q8NE00; -.
DR MaxQB; Q8NE00; -.
DR PaxDb; Q8NE00; -.
DR PeptideAtlas; Q8NE00; -.
DR PRIDE; Q8NE00; -.
DR ProteomicsDB; 73106; -. [Q8NE00-1]
DR ProteomicsDB; 73107; -. [Q8NE00-2]
DR Antibodypedia; 32018; 27 antibodies from 13 providers.
DR DNASU; 54868; -.
DR Ensembl; ENST00000335464.10; ENSP00000334849.5; ENSG00000109066.14. [Q8NE00-1]
DR Ensembl; ENST00000582330.2; ENSP00000461922.1; ENSG00000109066.14. [Q8NE00-1]
DR Ensembl; ENST00000582773.5; ENSP00000463205.1; ENSG00000109066.14. [Q8NE00-2]
DR GeneID; 54868; -.
DR KEGG; hsa:54868; -.
DR MANE-Select; ENST00000335464.10; ENSP00000334849.5; NM_017728.4; NP_060198.3.
DR UCSC; uc002jls.5; human. [Q8NE00-1]
DR CTD; 54868; -.
DR GeneCards; TMEM104; -.
DR HGNC; HGNC:25984; TMEM104.
DR HPA; ENSG00000109066; Low tissue specificity.
DR neXtProt; NX_Q8NE00; -.
DR OpenTargets; ENSG00000109066; -.
DR PharmGKB; PA142670753; -.
DR VEuPathDB; HostDB:ENSG00000109066; -.
DR eggNOG; KOG3832; Eukaryota.
DR GeneTree; ENSGT00390000001244; -.
DR HOGENOM; CLU_025541_4_0_1; -.
DR InParanoid; Q8NE00; -.
DR OMA; DVVCDQT; -.
DR PhylomeDB; Q8NE00; -.
DR TreeFam; TF314030; -.
DR PathwayCommons; Q8NE00; -.
DR SignaLink; Q8NE00; -.
DR BioGRID-ORCS; 54868; 12 hits in 1080 CRISPR screens.
DR ChiTaRS; TMEM104; human.
DR GenomeRNAi; 54868; -.
DR Pharos; Q8NE00; Tdark.
DR PRO; PR:Q8NE00; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q8NE00; protein.
DR Bgee; ENSG00000109066; Expressed in stromal cell of endometrium and 128 other tissues.
DR ExpressionAtlas; Q8NE00; baseline and differential.
DR Genevisible; Q8NE00; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR013057; AA_transpt_TM.
DR Pfam; PF01490; Aa_trans; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..496
FT /note="Transmembrane protein 104"
FT /id="PRO_0000254178"
FT TOPO_DOM 1..10
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 32..36
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 58..146
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..204
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..233
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 255..276
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..306
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..327
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 328..354
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..375
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 376..397
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 398..418
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 419..421
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 422..442
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 443..470
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 471..491
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 492..496
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT CARBOHYD 193
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 244..314
FT /note="AFAVMIVLALIRIGHGQGEGHPPLADFSGVRNLFGVCVYSFMCQHSLPSLIT
FT PVSSKRHLTRLVFLDYVLI -> DGPPGSVMGRAEEDASPAWPRSRCRCGGKLKLNSLY
FT PTSATCMAPDAPGAGQVKVGVNFLCLPPHRSTRPT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_021199"
FT VAR_SEQ 315..496
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_021200"
FT VARIANT 58
FT /note="V -> M (in dbSNP:rs2016126)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_028831"
FT VARIANT 439
FT /note="A -> T (in dbSNP:rs3803784)"
FT /id="VAR_028832"
SQ SEQUENCE 496 AA; 55679 MW; 4173D25DB4870426 CRC64;
MAGEITETGE LYSSYVGLVY MFNLIVGTGA LTMPKAFATA GWLVSLVLLV FLGFMSFVTT
TFVIEAMAAA NAQLHWKRME NLKEEEDDDS STASDSDVLI RDNYERAEKR PILSVQRRGS
PNPFEITDRV EMGQMASMFF NKVGVNLFYF CIIVYLYGDL AIYAAAVPFS LMQVTCSATG
NDSCGVEADT KYNDTDRCWG PLRRVDAYRI YLAIFTLLLG PFTFFDVQKT KYLQILTSLM
RWIAFAVMIV LALIRIGHGQ GEGHPPLADF SGVRNLFGVC VYSFMCQHSL PSLITPVSSK
RHLTRLVFLD YVLILAFYGL LSFTAIFCFR GDSLMDMYTL NFARCDVVGL AAVRFFLGLF
PVFTISTNFP IIAVTLRNNW KTLFHREGGT YPWVVDRVVF PTITLVPPVL VAFCTHDLES
LVGITGAYAG TGIQYVIPAF LVYHCRRDTQ LAFGCGVSNK HRSPFRHTFW VGFVLLWAFS
CFIFVTANII LSETKL
