TM104_PONAB
ID TM104_PONAB Reviewed; 496 AA.
AC Q5RCV1;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 25-MAY-2022, entry version 49.
DE RecName: Full=Transmembrane protein 104;
GN Name=TMEM104;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM104 family. {ECO:0000305}.
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DR EMBL; CR858167; CAH90406.1; -; mRNA.
DR RefSeq; NP_001125201.1; NM_001131729.1.
DR AlphaFoldDB; Q5RCV1; -.
DR STRING; 9601.ENSPPYP00000009665; -.
DR GeneID; 100172092; -.
DR KEGG; pon:100172092; -.
DR CTD; 54868; -.
DR eggNOG; KOG3832; Eukaryota.
DR InParanoid; Q5RCV1; -.
DR OrthoDB; 789592at2759; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR013057; AA_transpt_TM.
DR Pfam; PF01490; Aa_trans; 2.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..496
FT /note="Transmembrane protein 104"
FT /id="PRO_0000254180"
FT TOPO_DOM 1..10
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 32..36
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 58..146
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..204
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..233
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 255..276
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..306
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..327
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 328..354
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..375
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 376..397
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 398..418
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 419..421
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 422..442
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 443..470
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 471..491
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 492..496
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT CARBOHYD 193
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 496 AA; 55753 MW; E49DBF573060BBEE CRC64;
MAGEITETGE LYSSYVGLVY MFNLIVGTGA LTMPKAFATA GWLVSLVLLV FLGFMSFVTT
TFVIEAMAAA NAQLRWKRME NLKEEEDDDS STASDSDVLI RDNYERAEKR PILSVQRRGS
PNPFEITDRV EMGQMASMFF NKVGVNLFYF CIIVYLYGDL AIYAAAVPFS LMQVTCSATG
NDSCGVEADT KYNDTDRCWG PLRRVDAYRI YLAIFTLLLG PFTFFDVQKT KYLQILTSLM
RWIAFAVMIV LALVRIGHRQ GEGHPPLADF SGVRNLFGVC VYSFMCQHSL PSLITPVSSK
RHLTRLVFLD YVLILAFYGL LSFTAIFCFR GDSLMDMYTL NFARCDIVGL AAVRFFLGLF
PVFTISTNFP IIAVTLRNNW KTLFHREGGT YPWVVDRVVF PTITLVPPVL VAFCTHDLES
LVGITGAYAG TGIQYVIPAF LVYHCRRDTQ LAFGCGVGNK HRSPFRHTFW VGFVLLWAFS
CFIFVTANIV LSETKL
