TM105_HUMAN
ID TM105_HUMAN Reviewed; 129 AA.
AC Q8N8V8;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Transmembrane protein 105;
GN Name=TMEM105;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK096111; BAC04703.1; -; mRNA.
DR RefSeq; NP_848615.1; NM_178520.3.
DR AlphaFoldDB; Q8N8V8; -.
DR SMR; Q8N8V8; -.
DR STRING; 9606.ENSP00000329795; -.
DR BioMuta; TMEM105; -.
DR DMDM; 74729537; -.
DR PaxDb; Q8N8V8; -.
DR PeptideAtlas; Q8N8V8; -.
DR PRIDE; Q8N8V8; -.
DR UCSC; uc002kad.4; human.
DR GeneCards; TMEM105; -.
DR HGNC; HGNC:26794; TMEM105.
DR neXtProt; NX_Q8N8V8; -.
DR PharmGKB; PA142670754; -.
DR eggNOG; ENOG502TKS0; Eukaryota.
DR HOGENOM; CLU_161739_0_0_1; -.
DR InParanoid; Q8N8V8; -.
DR OrthoDB; 1405444at2759; -.
DR PhylomeDB; Q8N8V8; -.
DR TreeFam; TF340518; -.
DR PathwayCommons; Q8N8V8; -.
DR SignaLink; Q8N8V8; -.
DR BioGRID-ORCS; 284186; 14 hits in 1063 CRISPR screens.
DR GenomeRNAi; 284186; -.
DR Pharos; Q8N8V8; Tdark.
DR PRO; PR:Q8N8V8; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q8N8V8; protein.
DR Genevisible; Q8N8V8; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..129
FT /note="Transmembrane protein 105"
FT /id="PRO_0000274356"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 122
FT /note="R -> W (in dbSNP:rs9916085)"
FT /id="VAR_051426"
SQ SEQUENCE 129 AA; 13990 MW; FC17DF0141551265 CRC64;
MLLKVRRASL KPPATPHQGA FRAGNVIGQL IYLLTWSLFT AWLRPPTLLQ GPRTSPQGSP
PRSPWGDCAE PSCLCEMKIR RRRHEGPAWG QSGFLAGGLH LVPSSLSLAA CGVVRMKGLW
GRGAGIRGR
