ID   BSSS_ECOLI              Reviewed;          84 AA.
AC   P0AB33; P75927; Q9R374;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Biofilm regulator BssS;
GN   Name=bssS; Synonyms=yceP; OrderedLocusNames=b1060, JW5152;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=8905232; DOI=10.1093/dnares/3.3.137;
RA   Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K.,
RA   Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S.,
RA   Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K., Mori H.,
RA   Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G.,
RA   Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M.,
RA   Horiuchi T.;
RT   "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT   the 12.7-28.0 min region on the linkage map.";
RL   DNA Res. 3:137-155(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   INDUCTION BY COLD SHOCK.
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=14527658; DOI=10.1016/s0923-2508(03)00167-0;
RA   Polissi A., De Laurentis W., Zangrossi S., Briani F., Longhi V., Pesole G.,
RA   Deho G.;
RT   "Changes in Escherichia coli transcriptome during acclimatization at low
RT   temperature.";
RL   Res. Microbiol. 154:573-580(2003).
RN   [5]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=K12 / BW25113;
RX   PubMed=16597943; DOI=10.1128/aem.72.4.2449-2459.2006;
RA   Domka J., Lee J., Wood T.K.;
RT   "YliH (BssR) and YceP (BssS) regulate Escherichia coli K-12 biofilm
RT   formation by influencing cell signaling.";
RL   Appl. Environ. Microbiol. 72:2449-2459(2006).
CC   -!- FUNCTION: Represses biofilm formation in M9C glu and LB glu media but
CC       not in M9C and LB media. Seems to act as a global regulator of several
CC       genes involved in catabolite repression and stress response and
CC       regulation of the uptake and export of signaling pathways. Could be
CC       involved the regulation of indole as well as uptake and export of AI-2
CC       through a cAMP-dependent pathway. {ECO:0000269|PubMed:16597943}.
CC   -!- INDUCTION: After 3 hrs of cold shock. {ECO:0000269|PubMed:14527658}.
CC   -!- DISRUPTION PHENOTYPE: Cells show increased biofilm formation when
CC       glucose is present in the medium. In a continuous-flow system with M9C
CC       medium supplemented with glucose, the biofilm had a 240-fold greater
CC       biomass, a 2800 fold-greater average thickness and a 16-fold increased
CC       surface coverage than the wild-type. {ECO:0000269|PubMed:16597943}.
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DR   EMBL; U00096; AAC74144.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAA35857.2; -; Genomic_DNA.
DR   PIR; A64849; A64849.
DR   RefSeq; NP_415578.3; NC_000913.3.
DR   RefSeq; WP_000414438.1; NZ_SSZK01000053.1.
DR   AlphaFoldDB; P0AB33; -.
DR   SMR; P0AB33; -.
DR   BioGRID; 4260077; 191.
DR   BioGRID; 850464; 2.
DR   IntAct; P0AB33; 3.
DR   STRING; 511145.b1060; -.
DR   PaxDb; P0AB33; -.
DR   PRIDE; P0AB33; -.
DR   EnsemblBacteria; AAC74144; AAC74144; b1060.
DR   EnsemblBacteria; BAA35857; BAA35857; BAA35857.
DR   GeneID; 66508885; -.
DR   GeneID; 946104; -.
DR   KEGG; ecj:JW5152; -.
DR   KEGG; eco:b1060; -.
DR   PATRIC; fig|1411691.4.peg.1208; -.
DR   EchoBASE; EB4081; -.
DR   eggNOG; ENOG5032S2R; Bacteria.
DR   HOGENOM; CLU_193121_0_0_6; -.
DR   OMA; YILQAGI; -.
DR   PhylomeDB; P0AB33; -.
DR   BioCyc; EcoCyc:G6557-MON; -.
DR   PRO; PR:P0AB33; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:1900190; P:regulation of single-species biofilm formation; IMP:EcoCyc.
DR   GO; GO:0090609; P:single-species submerged biofilm formation; IMP:CACAO.
DR   InterPro; IPR025730; Biofilm_BssS.
DR   Pfam; PF13991; BssS; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..84
FT                   /note="Biofilm regulator BssS"
FT                   /id="PRO_0000168823"
SQ   SEQUENCE   84 AA;  9664 MW;  1D7103C964E5D5FF CRC64;
     MEKNNEVIQT HPLVGWDIST VDSYDALMLR LHYQTPNKSE QEGTEVGQTL WLTTDVARQF
     ISILEAGIAK IESGDFQVNE YRRH