TM108_BOVIN
ID TM108_BOVIN Reviewed; 583 AA.
AC A6QLF8;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=Transmembrane protein 108 {ECO:0000250|UniProtKB:Q6UXF1};
DE AltName: Full=Retrolinkin {ECO:0000305};
GN Name=TMEM108 {ECO:0000250|UniProtKB:Q6UXF1};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal lung;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transmembrane protein required for proper cognitive
CC functions. Involved in the development of dentate gyrus (DG) neuron
CC circuitry, is necessary for AMPA receptors surface expression and
CC proper excitatory postsynaptic currents of DG granule neurons.
CC Regulates the organization and stability of the microtubule network of
CC sensory neurons to allow axonal transport. Through the interaction with
CC DST, mediates the docking of the dynein/dynactin motor complex to
CC vesicle cargos for retrograde axonal transport. In hippocampal neurons,
CC required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2
CC and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2
CC early endocytic trafficking and mediate signaling from early endosomes.
CC {ECO:0000250|UniProtKB:Q8BHE4}.
CC -!- SUBUNIT: Interacts with DST (isoform 1). Interacts with SH3GL2.
CC Interacts (via N-terminus) with CYFIP1 and CYFIP2; the interactions
CC associate TMEM108 with the WAVE1 complex.
CC {ECO:0000250|UniProtKB:Q8BHE4}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q8BHE4}; Multi-
CC pass membrane protein {ECO:0000255}. Postsynaptic density
CC {ECO:0000250|UniProtKB:Q8BHE4}. Endosome membrane
CC {ECO:0000250|UniProtKB:Q8BHE4}. Cell projection, axon
CC {ECO:0000250|UniProtKB:Q8BHE4}. Cell projection, dendrite
CC {ECO:0000250|UniProtKB:Q8BHE4}. Early endosome
CC {ECO:0000250|UniProtKB:Q8BHE4}.
CC -!- PTM: Glycosylated. {ECO:0000250|UniProtKB:Q8BHE4}.
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DR EMBL; BC147949; AAI47950.1; -; mRNA.
DR RefSeq; NP_001095409.1; NM_001101939.2.
DR AlphaFoldDB; A6QLF8; -.
DR STRING; 9913.ENSBTAP00000024636; -.
DR PaxDb; A6QLF8; -.
DR GeneID; 511034; -.
DR KEGG; bta:511034; -.
DR CTD; 66000; -.
DR eggNOG; ENOG502RXTY; Eukaryota.
DR InParanoid; A6QLF8; -.
DR OrthoDB; 1160560at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0030424; C:axon; ISS:UniProtKB.
DR GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0005769; C:early endosome; ISS:UniProtKB.
DR GO; GO:0010008; C:endosome membrane; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0014069; C:postsynaptic density; ISS:UniProtKB.
DR GO; GO:0036477; C:somatodendritic compartment; ISS:UniProtKB.
DR GO; GO:1990416; P:cellular response to brain-derived neurotrophic factor stimulus; ISS:UniProtKB.
DR GO; GO:0097484; P:dendrite extension; ISS:UniProtKB.
DR GO; GO:0021542; P:dentate gyrus development; ISS:UniProtKB.
DR GO; GO:0098815; P:modulation of excitatory postsynaptic potential; ISS:UniProtKB.
DR GO; GO:0031175; P:neuron projection development; ISS:UniProtKB.
DR GO; GO:0051388; P:positive regulation of neurotrophin TRK receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0097106; P:postsynaptic density organization; ISS:UniProtKB.
DR GO; GO:0006898; P:receptor-mediated endocytosis; ISS:UniProtKB.
DR GO; GO:0008090; P:retrograde axonal transport; ISS:UniProtKB.
DR InterPro; IPR031508; TMEM108.
DR PANTHER; PTHR28673; PTHR28673; 1.
DR Pfam; PF15759; TMEM108; 1.
DR PROSITE; PS00430; TONB_DEPENDENT_REC_1; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Endosome; Glycoprotein; Membrane; Reference proteome;
KW Synapse; Transmembrane; Transmembrane helix.
FT CHAIN 1..583
FT /note="Transmembrane protein 108"
FT /id="PRO_0000367276"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 477..497
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 31..176
FT /note="Interacts with SH3GL2"
FT /evidence="ECO:0000250|UniProtKB:Q8BHE4"
FT REGION 71..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 180..413
FT /note="Interacts with DST (isoform 1)"
FT /evidence="ECO:0000250|UniProtKB:Q8BHE4"
FT REGION 376..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 498..583
FT /note="Interaction with CYFIP2"
FT /evidence="ECO:0000250|UniProtKB:Q8BHE4"
FT COMPBIAS 71..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..360
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 583 AA; 60785 MW; 7D24BB644C17B3D3 CRC64;
MKRSLQALYC QLLSFLLTLA LTEALVFAAQ EPSPRESLQV SPSGTIPGTM VTASLSSTRH
SSMVATPASV VTPTPHPDGP SSQATAPMAT TTPHLDGHPP TNTISTIMAT ASTPHSEGSL
STGPLPAAMA TTSSHSEGRA PGETAPTILL TKPGEATSRP PTAPSRATIR RPPRPPGSSR
KGAGSSPRPI PAAPSGHAGR KDGQRGRNQS STHLGQKRPL GKIFQIYKGN FTGSVEPDPS
TFTPRNPLWG YSSSPQPQTV AATSAPSRTS WVPPTTPLVP VEDKPSLSRA DQGGGSTFTS
QGGEPDATAA SGTPASQQRA PVPSQRPHGD PQDGSSHSDS WLTVTPGTSR PPSTNSGVFA
ATTGPIQAAF DASVSVPSEG LPQGTSLAPQ APAHPTWASE STVSQAEEKA VATPTPTMMG
RVPSPLSTVV STATGNFLNR LVPAGTWKPG TAGNISHVAE GDKPQQRATI CLSKMDIAWV
ILAISVPISS CSVLLTVCCL RRKKKPANPE NSLSYWNNAI TMDYFSKHAV ELPREIQSLE
TSEDQLSEPR SPANGDYRDT GMVLVNPFCQ ETLFVGNDQV SEI
