TM109_HUMAN
ID TM109_HUMAN Reviewed; 243 AA.
AC Q9BVC6;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Transmembrane protein 109;
DE AltName: Full=Mitsugumin-23;
DE Short=Mg23;
DE Flags: Precursor;
GN Name=TMEM109;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP PROTEIN SEQUENCE OF 48-59 AND 207-215, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC TISSUE=Platelet;
RA Bienvenut W.V., Claeys D.;
RL Submitted (NOV-2005) to UniProtKB.
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [4]
RP FUNCTION, AND INTERACTION WITH CRYAB.
RX PubMed=23542032; DOI=10.1016/j.febslet.2013.03.024;
RA Yamashita A., Taniwaki T., Kaikoi Y., Yamazaki T.;
RT "Protective role of the endoplasmic reticulum protein mitsugumin23 against
RT ultraviolet C-induced cell death.";
RL FEBS Lett. 587:1299-1303(2013).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
CC -!- FUNCTION: May mediate cellular response to DNA damage by protecting
CC against ultraviolet C-induced cell death (PubMed:23542032). Can form
CC voltage-gated calcium and potassium channels in vitro (By similarity).
CC {ECO:0000250|UniProtKB:O77751, ECO:0000269|PubMed:23542032}.
CC -!- SUBUNIT: Homooligomer (By similarity). Interacts with CRYAB
CC (PubMed:23542032). {ECO:0000250|UniProtKB:O77751,
CC ECO:0000269|PubMed:23542032}.
CC -!- INTERACTION:
CC Q9BVC6; P41181: AQP2; NbExp=3; IntAct=EBI-1057733, EBI-12701138;
CC Q9BVC6; O43315: AQP9; NbExp=3; IntAct=EBI-1057733, EBI-17444777;
CC Q9BVC6; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-1057733, EBI-781551;
CC Q9BVC6; Q8NBJ4: GOLM1; NbExp=3; IntAct=EBI-1057733, EBI-712073;
CC Q9BVC6; Q8TED1: GPX8; NbExp=3; IntAct=EBI-1057733, EBI-11721746;
CC Q9BVC6; O14880: MGST3; NbExp=3; IntAct=EBI-1057733, EBI-724754;
CC Q9BVC6; Q9H2K0: MTIF3; NbExp=3; IntAct=EBI-1057733, EBI-3923617;
CC Q9BVC6; Q13113: PDZK1IP1; NbExp=3; IntAct=EBI-1057733, EBI-716063;
CC Q9BVC6; Q96K19-5: RNF170; NbExp=3; IntAct=EBI-1057733, EBI-12055631;
CC Q9BVC6; Q9NR31: SAR1A; NbExp=3; IntAct=EBI-1057733, EBI-3920694;
CC Q9BVC6; Q05940: SLC18A2; NbExp=3; IntAct=EBI-1057733, EBI-18036244;
CC Q9BVC6; O43278-2: SPINT1; NbExp=3; IntAct=EBI-1057733, EBI-12078338;
CC Q9BVC6; P27105: STOM; NbExp=3; IntAct=EBI-1057733, EBI-1211440;
CC Q9BVC6; Q4KMG9: TMEM52B; NbExp=3; IntAct=EBI-1057733, EBI-18178701;
CC Q9BVC6; Q96HE8: TMEM80; NbExp=3; IntAct=EBI-1057733, EBI-11742770;
CC -!- SUBCELLULAR LOCATION: Nucleus outer membrane
CC {ECO:0000250|UniProtKB:O77751}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:O77751}. Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:O77751}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:O77751}. Sarcoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:O77751}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:O77751}.
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DR EMBL; BC001309; AAH01309.1; -; mRNA.
DR CCDS; CCDS7996.1; -.
DR RefSeq; NP_076997.1; NM_024092.2.
DR AlphaFoldDB; Q9BVC6; -.
DR SMR; Q9BVC6; -.
DR BioGRID; 122524; 105.
DR IntAct; Q9BVC6; 55.
DR MINT; Q9BVC6; -.
DR STRING; 9606.ENSP00000227525; -.
DR TCDB; 1.A.74.1.2; the mitsugumin 23 (mg23) family.
DR GlyGen; Q9BVC6; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9BVC6; -.
DR PhosphoSitePlus; Q9BVC6; -.
DR SwissPalm; Q9BVC6; -.
DR BioMuta; TMEM109; -.
DR DMDM; 74733312; -.
DR EPD; Q9BVC6; -.
DR jPOST; Q9BVC6; -.
DR MassIVE; Q9BVC6; -.
DR MaxQB; Q9BVC6; -.
DR PaxDb; Q9BVC6; -.
DR PeptideAtlas; Q9BVC6; -.
DR PRIDE; Q9BVC6; -.
DR ProteomicsDB; 79198; -.
DR TopDownProteomics; Q9BVC6; -.
DR Antibodypedia; 2041; 77 antibodies from 17 providers.
DR DNASU; 79073; -.
DR Ensembl; ENST00000227525.8; ENSP00000227525.3; ENSG00000110108.10.
DR Ensembl; ENST00000536171.1; ENSP00000443990.1; ENSG00000110108.10.
DR GeneID; 79073; -.
DR KEGG; hsa:79073; -.
DR MANE-Select; ENST00000227525.8; ENSP00000227525.3; NM_024092.3; NP_076997.1.
DR UCSC; uc001nqg.4; human.
DR CTD; 79073; -.
DR DisGeNET; 79073; -.
DR GeneCards; TMEM109; -.
DR HGNC; HGNC:28771; TMEM109.
DR HPA; ENSG00000110108; Low tissue specificity.
DR MIM; 619168; gene.
DR neXtProt; NX_Q9BVC6; -.
DR OpenTargets; ENSG00000110108; -.
DR PharmGKB; PA142670760; -.
DR VEuPathDB; HostDB:ENSG00000110108; -.
DR eggNOG; ENOG502S0EJ; Eukaryota.
DR GeneTree; ENSGT00390000015704; -.
DR HOGENOM; CLU_099892_0_0_1; -.
DR InParanoid; Q9BVC6; -.
DR OMA; VFKVILM; -.
DR OrthoDB; 1631905at2759; -.
DR PhylomeDB; Q9BVC6; -.
DR TreeFam; TF332238; -.
DR PathwayCommons; Q9BVC6; -.
DR SignaLink; Q9BVC6; -.
DR BioGRID-ORCS; 79073; 13 hits in 1087 CRISPR screens.
DR ChiTaRS; TMEM109; human.
DR GenomeRNAi; 79073; -.
DR Pharos; Q9BVC6; Tbio.
DR PRO; PR:Q9BVC6; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9BVC6; protein.
DR Bgee; ENSG00000110108; Expressed in thoracic aorta and 203 other tissues.
DR Genevisible; Q9BVC6; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005640; C:nuclear outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR GO; GO:0071480; P:cellular response to gamma radiation; IMP:MGI.
DR GO; GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IBA:GO_Central.
DR GO; GO:0060548; P:negative regulation of cell death; IMP:MGI.
DR GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR InterPro; IPR039492; TMEM109.
DR PANTHER; PTHR14550; PTHR14550; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Endoplasmic reticulum; Ion channel;
KW Ion transport; Membrane; Nucleus; Reference proteome;
KW Sarcoplasmic reticulum; Signal; Transmembrane; Transmembrane helix;
KW Transport; Voltage-gated channel.
FT SIGNAL 1..33
FT /evidence="ECO:0000255"
FT CHAIN 34..243
FT /note="Transmembrane protein 109"
FT /id="PRO_0000044618"
FT TOPO_DOM 34..83
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:O77751"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 105..135
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:O77751"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..185
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:O77751"
FT TRANSMEM 186..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 206..243
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:O77751"
SQ SEQUENCE 243 AA; 26210 MW; E405591236B94BB3 CRC64;
MAASSISSPW GKHVFKAILM VLVALILLHS ALAQSRRDFA PPGQQKREAP VDVLTQIGRS
VRGTLDAWIG PETMHLVSES SSQVLWAISS AISVAFFALS GIAAQLLNAL GLAGDYLAQG
LKLSPGQVQT FLLWGAGALV VYWLLSLLLG LVLALLGRIL WGLKLVIFLA GFVALMRSVP
DPSTRALLLL ALLILYALLS RLTGSRASGA QLEAKVRGLE RQVEELRWRQ RRAAKGARSV
EEE
