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TM109_RABIT
ID   TM109_RABIT             Reviewed;         243 AA.
AC   O77751;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Transmembrane protein 109;
DE   AltName: Full=Mitsugumin-23;
DE            Short=Mg23;
DE   Flags: Precursor;
GN   Name=TMEM109;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, SUBCELLULAR LOCATION,
RP   AND TISSUE SPECIFICITY.
RC   TISSUE=Skeletal muscle;
RX   PubMed=9720923; DOI=10.1016/s0014-5793(98)00864-3;
RA   Nishi M., Komazaki S., Iino M., Kanagawa K., Takeshima H.;
RT   "Mitsugumin23, a novel transmembrane protein on endoplasmic reticulum and
RT   nuclear membranes.";
RL   FEBS Lett. 432:191-196(1998).
RN   [2]
RP   FUNCTION, SUBUNIT, TOPOLOGY, AND SUBCELLULAR LOCATION.
RX   PubMed=21381722; DOI=10.1021/bi1019447;
RA   Venturi E., Mio K., Nishi M., Ogura T., Moriya T., Pitt S.J., Okuda K.,
RA   Kakizawa S., Sitsapesan R., Sato C., Takeshima H.;
RT   "Mitsugumin 23 forms a massive bowl-shaped assembly and cation-conducting
RT   channel.";
RL   Biochemistry 50:2623-2632(2011).
CC   -!- FUNCTION: May mediate cellular response to DNA damage by protecting
CC       against ultraviolet C-induced cell death (By similarity). Can form
CC       voltage-gated calcium and potassium channels in vitro
CC       (PubMed:21381722). {ECO:0000250|UniProtKB:Q3UBX0,
CC       ECO:0000250|UniProtKB:Q9BVC6, ECO:0000269|PubMed:21381722}.
CC   -!- SUBUNIT: Homooligomer (PubMed:21381722). Interacts with CRYAB (By
CC       similarity). {ECO:0000250|UniProtKB:Q9BVC6,
CC       ECO:0000269|PubMed:21381722}.
CC   -!- SUBCELLULAR LOCATION: Nucleus outer membrane
CC       {ECO:0000269|PubMed:9720923}; Multi-pass membrane protein
CC       {ECO:0000305|PubMed:21381722}. Endoplasmic reticulum membrane
CC       {ECO:0000269|PubMed:21381722, ECO:0000269|PubMed:9720923}; Multi-pass
CC       membrane protein {ECO:0000305|PubMed:21381722}. Sarcoplasmic reticulum
CC       membrane {ECO:0000269|PubMed:21381722, ECO:0000269|PubMed:9720923};
CC       Multi-pass membrane protein {ECO:0000269|PubMed:21381722}.
CC   -!- TISSUE SPECIFICITY: Widely expressed. Expressed in skeletal, cardiac
CC       and smooth muscle cells, in brain, including neuroglial cells, cerebral
CC       cortex neurons and cerebellum, but not Purkinje cells. Also detected in
CC       Paneth and Goblet cells of the small intestine (but not in the
CC       epithelium), duodenal gland, pancreas, parotid gland, testis, thyroid
CC       gland and adrenal gland, as well as in epidermis, choroid plexus,
CC       ductus epididymidis, lymphocytes, fibroblasts, endothelial cells and
CC       seminiferous epithelial cells (at protein level). Not detected in
CC       mucous cells of the duodenal gland, in hepatocytes nor in uriniferous
CC       tubules. {ECO:0000269|PubMed:9720923}.
CC   -!- PTM: The N-terminus is blocked.
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DR   EMBL; AB013721; BAA33366.1; -; mRNA.
DR   RefSeq; NP_001075462.1; NM_001081993.1.
DR   AlphaFoldDB; O77751; -.
DR   STRING; 9986.ENSOCUP00000013488; -.
DR   PRIDE; O77751; -.
DR   GeneID; 100008604; -.
DR   KEGG; ocu:100008604; -.
DR   CTD; 79073; -.
DR   eggNOG; ENOG502S0EJ; Eukaryota.
DR   InParanoid; O77751; -.
DR   OrthoDB; 1631905at2759; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:MGI.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031965; C:nuclear membrane; IDA:MGI.
DR   GO; GO:0005640; C:nuclear outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0071480; P:cellular response to gamma radiation; IEA:InterPro.
DR   GO; GO:0060548; P:negative regulation of cell death; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   InterPro; IPR039492; TMEM109.
DR   PANTHER; PTHR14550; PTHR14550; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Endoplasmic reticulum; Ion channel;
KW   Ion transport; Membrane; Nucleus; Reference proteome;
KW   Sarcoplasmic reticulum; Signal; Transmembrane; Transmembrane helix;
KW   Transport; Voltage-gated channel.
FT   SIGNAL          1..33
FT                   /evidence="ECO:0000255"
FT   CHAIN           34..243
FT                   /note="Transmembrane protein 109"
FT                   /id="PRO_0000044620"
FT   TOPO_DOM        34..83
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000305|PubMed:21381722"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        105..135
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305|PubMed:21381722"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        157..185
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000305|PubMed:21381722"
FT   TRANSMEM        186..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        206..243
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305|PubMed:21381722"
SQ   SEQUENCE   243 AA;  26146 MW;  89A0AB316F657D36 CRC64;
     MAGSGSSAPW GKHLLHAVLM VLVALVLLHS ALAQSHRDFA PPGQQRREAP VDLLTQIGRS
     VRETLDTWIG PETMHLISET LSQVMWAISS AISVAFFALS GIAAQLLTAL GLDGDHLTQG
     LKLSPSQVQT FLLWGAGALV VYWLLSLLLG LVLAVLGRIL GGLKLVIFLA GFVALVRSVP
     DPSTRALLLL ALLTLYALLS RLTGSRASGA QLEAKVRGLE RQVDELRWRQ RRAAKGARSV
     EEE
 
 
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