ID   TM109_RAT               Reviewed;         243 AA.
AC   Q6AYQ4;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Transmembrane protein 109;
DE   AltName: Full=Mitsugumin-23;
DE            Short=Mg23;
DE   Flags: Precursor;
GN   Name=Tmem109;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May mediate cellular response to DNA damage by protecting
CC       against ultraviolet C-induced cell death. Can form voltage-gated
CC       calcium and potassium channels in vitro. {ECO:0000250|UniProtKB:Q3UBX0,
CC       ECO:0000250|UniProtKB:Q9BVC6}.
CC   -!- SUBUNIT: Homooligomer. Interacts with CRYAB.
CC       {ECO:0000250|UniProtKB:O77751, ECO:0000250|UniProtKB:Q9BVC6}.
CC   -!- SUBCELLULAR LOCATION: Nucleus outer membrane
CC       {ECO:0000250|UniProtKB:O77751}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:O77751}. Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:O77751}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:O77751}. Sarcoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:O77751}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:O77751}.
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DR   EMBL; BC078955; AAH78955.1; -; mRNA.
DR   RefSeq; NP_001007737.1; NM_001007736.1.
DR   RefSeq; XP_006231121.1; XM_006231059.3.
DR   RefSeq; XP_008758458.1; XM_008760236.2.
DR   RefSeq; XP_008758459.1; XM_008760237.2.
DR   AlphaFoldDB; Q6AYQ4; -.
DR   SMR; Q6AYQ4; -.
DR   BioGRID; 262912; 1.
DR   STRING; 10116.ENSRNOP00000036054; -.
DR   iPTMnet; Q6AYQ4; -.
DR   PhosphoSitePlus; Q6AYQ4; -.
DR   jPOST; Q6AYQ4; -.
DR   PaxDb; Q6AYQ4; -.
DR   PRIDE; Q6AYQ4; -.
DR   Ensembl; ENSRNOT00000118882; ENSRNOP00000090031; ENSRNOG00000028017.
DR   GeneID; 361732; -.
DR   KEGG; rno:361732; -.
DR   UCSC; RGD:1359538; rat.
DR   CTD; 79073; -.
DR   RGD; 1359538; Tmem109.
DR   eggNOG; ENOG502S0EJ; Eukaryota.
DR   GeneTree; ENSGT00390000015704; -.
DR   HOGENOM; CLU_099892_0_0_1; -.
DR   InParanoid; Q6AYQ4; -.
DR   OMA; VFKVILM; -.
DR   OrthoDB; 1631905at2759; -.
DR   PhylomeDB; Q6AYQ4; -.
DR   TreeFam; TF332238; -.
DR   PRO; PR:Q6AYQ4; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000028017; Expressed in skeletal muscle tissue and 20 other tissues.
DR   Genevisible; Q6AYQ4; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005640; C:nuclear outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0071480; P:cellular response to gamma radiation; ISO:RGD.
DR   GO; GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; ISO:RGD.
DR   GO; GO:0060548; P:negative regulation of cell death; ISO:RGD.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   InterPro; IPR039492; TMEM109.
DR   PANTHER; PTHR14550; PTHR14550; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Ion channel; Ion transport; Membrane; Nucleus;
KW   Reference proteome; Sarcoplasmic reticulum; Signal; Transmembrane;
KW   Transmembrane helix; Transport; Voltage-gated channel.
FT   SIGNAL          1..33
FT                   /evidence="ECO:0000255"
FT   CHAIN           34..243
FT                   /note="Transmembrane protein 109"
FT                   /id="PRO_0000044621"
FT   TOPO_DOM        34..83
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250|UniProtKB:O77751"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        105..135
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:O77751"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        157..185
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250|UniProtKB:O77751"
FT   TRANSMEM        186..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        206..243
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:O77751"
SQ   SEQUENCE   243 AA;  26242 MW;  FB4772B148579C9A CRC64;
     MAGAHSNPSW SRHLFKAVLM VLGALLLVHS ASAQTHREFA SPGQQKRESS ADILTEIGRS
     LKETLDTWLG PETMHVISET LLQVMWAISS AISVACFALS GIAAQLLSAL GLDGEQLTQV
     LKLSPSQVQT LLLWGAAALV IYWLLSLLLG LVLALLGRIL GGLKLVLFVA GFVGLVRSVP
     DPSTRALLLL ALLTVFALLS RLTGSRSSGT HLEAKVRGLE RQIEELRGRQ RRAAKIPRSM
     EEE