ID   BST12_CAEEL             Reviewed;         434 AA.
AC   O45363;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Bestrophin homolog 12;
GN   Name=best-12; ORFNames=F14H3.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Forms chloride channels. {ECO:0000250}.
CC   -!- SUBUNIT: Forms oligomers. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the bestrophin family. {ECO:0000305}.
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DR   EMBL; Z83105; CAB05483.1; -; Genomic_DNA.
DR   PIR; T20922; T20922.
DR   RefSeq; NP_507036.1; NM_074635.1.
DR   AlphaFoldDB; O45363; -.
DR   SMR; O45363; -.
DR   STRING; 6239.F14H3.2; -.
DR   PaxDb; O45363; -.
DR   EnsemblMetazoa; F14H3.2.1; F14H3.2.1; WBGene00008821.
DR   EnsemblMetazoa; F14H3.2.2; F14H3.2.2; WBGene00008821.
DR   GeneID; 184489; -.
DR   KEGG; cel:CELE_F14H3.2; -.
DR   UCSC; F14H3.2; c. elegans.
DR   CTD; 184489; -.
DR   WormBase; F14H3.2; CE15827; WBGene00008821; best-12.
DR   eggNOG; KOG3547; Eukaryota.
DR   GeneTree; ENSGT00970000195944; -.
DR   HOGENOM; CLU_018069_7_1_1; -.
DR   InParanoid; O45363; -.
DR   OMA; RFAINET; -.
DR   OrthoDB; 279144at2759; -.
DR   PhylomeDB; O45363; -.
DR   Reactome; R-CEL-2672351; Stimuli-sensing channels.
DR   PRO; PR:O45363; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00008821; Expressed in material anatomical entity and 2 other tissues.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005254; F:chloride channel activity; IBA:GO_Central.
DR   InterPro; IPR000615; Bestrophin.
DR   InterPro; IPR021134; Bestrophin/UPF0187.
DR   PANTHER; PTHR10736; PTHR10736; 1.
DR   Pfam; PF01062; Bestrophin; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chloride; Chloride channel; Ion channel; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..434
FT                   /note="Bestrophin homolog 12"
FT                   /id="PRO_0000143129"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   434 AA;  50338 MW;  ABB144F08C968FF1 CRC64;
     MTIPYLADLK DQTECKTCPK ILTRCKGSLY KVILHEFLMT AGAYFGVFLV FRFAINETQR
     EYAAEVFKKL KEQQNVCIPM QMMLAFFIAT VADQWEKIFE NVGYIENAAL AVATFLPDGK
     EKRDNNGNVI LAKVDNSNVR RNIIRYLVLS QILGIRDVSE LVKKRFANYD MIKATGVLQD
     HEEPLLKKVP CKTYAESFVP ITWIMSILQK FASKNEENLY YDTVYLEITD FYKKIIKLTR
     YDLIPIPLAY PQAVFLAVRI YFFFCLFTRQ HLDLEENWAL SHWGFPLLTT LQFIFLVGCM
     KVAEILLNPM GQDDENFECN YVMDKNLFVG LTIVSSEHTE CPELEEVIGD DYVPWYPDDC
     KSKEEKNQEE LKKYLESVDF QAVTSSDQGE NDEVSTMMKV EQNSLLVCGR EKFYEGGGFR
     NSDVYPKQRA NYPH