ID   BST13_CAEEL             Reviewed;         413 AA.
AC   O45435;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Bestrophin homolog 13;
GN   Name=best-13; ORFNames=F32B6.9;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Forms chloride channels. {ECO:0000250}.
CC   -!- SUBUNIT: Forms oligomers. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the bestrophin family. {ECO:0000305}.
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DR   EMBL; Z81074; CAB03043.1; -; Genomic_DNA.
DR   PIR; T21644; T21644.
DR   RefSeq; NP_501784.1; NM_069383.1.
DR   AlphaFoldDB; O45435; -.
DR   SMR; O45435; -.
DR   STRING; 6239.F32B6.9; -.
DR   iPTMnet; O45435; -.
DR   EPD; O45435; -.
DR   PaxDb; O45435; -.
DR   PeptideAtlas; O45435; -.
DR   EnsemblMetazoa; F32B6.9.1; F32B6.9.1; WBGene00009323.
DR   GeneID; 185198; -.
DR   KEGG; cel:CELE_F32B6.9; -.
DR   UCSC; F32B6.9; c. elegans.
DR   CTD; 185198; -.
DR   WormBase; F32B6.9; CE09864; WBGene00009323; best-13.
DR   eggNOG; KOG3547; Eukaryota.
DR   HOGENOM; CLU_018069_0_1_1; -.
DR   InParanoid; O45435; -.
DR   OMA; NDYEPLQ; -.
DR   OrthoDB; 279144at2759; -.
DR   PhylomeDB; O45435; -.
DR   Reactome; R-CEL-2672351; Stimuli-sensing channels.
DR   PRO; PR:O45435; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00009323; Expressed in embryo and 4 other tissues.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005254; F:chloride channel activity; IBA:GO_Central.
DR   InterPro; IPR000615; Bestrophin.
DR   InterPro; IPR021134; Bestrophin/UPF0187.
DR   PANTHER; PTHR10736; PTHR10736; 1.
DR   Pfam; PF01062; Bestrophin; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chloride; Chloride channel; Ion channel; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..413
FT                   /note="Bestrophin homolog 13"
FT                   /id="PRO_0000143130"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   413 AA;  48965 MW;  A66E69A83C78790B CRC64;
     MTISYSGNVI RILLRWKGSI WRTAWKELLI YLILYYSVRV FYLKGIDLID DDEDDRLKMR
     RMFETFCRQC DSYTRLIPLT FLLGFYVSNV VARWWRQFET LYWPEDILSV LCTVLHQHDE
     KSKRRRHTIA RYLNLANALA WRDISSKIRL RFPSVHSLIE SGLLTEKEYQ ILEAMHAENE
     SSRWITPLHW IQLIMRQVEE EHKPTASLFN QFVGELRIFR QSLRKLYSYD WVCVPLVYTQ
     VAALATYSFF FFTLFGRQPL FPDIETGKEL DLVVPVFTIV QFLFFVGWFK VGQDLMRPFG
     LDDDDIELNY ILDRNVRISF AIVNQLQESP IPDFESNDDK LWHEMHPPTK DGETSPIPRI
     PQLPHSKYSK QLSEHPPRLH AYVPIDDGKG SIKDLESHHG CVSLKKDKKH ISW