ID   TM115_BOVIN             Reviewed;         351 AA.
AC   A4FUB8;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Transmembrane protein 115 {ECO:0000305};
GN   Name=TMEM115 {ECO:0000305};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal pons, and Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in retrograde transport of proteins from the
CC       Golgi to the endoplasmic reticulum. May indirectly play a role in
CC       protein glycosylation in the Golgi. {ECO:0000250|UniProtKB:Q12893}.
CC   -!- SUBUNIT: Homooligomer. Interacts with COPB1. May interact with LMAN1.
CC       Interacts with the COG complex; probably through COG3.
CC       {ECO:0000250|UniProtKB:Q12893}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane
CC       {ECO:0000250|UniProtKB:Q12893}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q12893}.
CC   -!- SIMILARITY: Belongs to the TMEM115 family. {ECO:0000305}.
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DR   EMBL; BC114682; AAI14683.1; -; mRNA.
DR   EMBL; BC140647; AAI40648.1; -; mRNA.
DR   RefSeq; NP_001076930.1; NM_001083461.3.
DR   AlphaFoldDB; A4FUB8; -.
DR   STRING; 9913.ENSBTAP00000003411; -.
DR   PaxDb; A4FUB8; -.
DR   Ensembl; ENSBTAT00000003411; ENSBTAP00000003411; ENSBTAG00000019161.
DR   GeneID; 532459; -.
DR   KEGG; bta:532459; -.
DR   CTD; 11070; -.
DR   VEuPathDB; HostDB:ENSBTAG00000019161; -.
DR   VGNC; VGNC:32214; NPRL2.
DR   eggNOG; KOG2890; Eukaryota.
DR   GeneTree; ENSGT00390000001414; -.
DR   HOGENOM; CLU_043563_2_0_1; -.
DR   InParanoid; A4FUB8; -.
DR   OMA; FACLFPD; -.
DR   OrthoDB; 1156492at2759; -.
DR   TreeFam; TF315100; -.
DR   Proteomes; UP000009136; Chromosome 22.
DR   Bgee; ENSBTAG00000019161; Expressed in retina and 107 other tissues.
DR   ExpressionAtlas; A4FUB8; baseline.
DR   GO; GO:0032580; C:Golgi cisterna membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
DR   GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; ISS:UniProtKB.
DR   InterPro; IPR035952; Rhomboid-like_sf.
DR   InterPro; IPR013861; TMEM115/Pdh1/Rbl19.
DR   PANTHER; PTHR13377; PTHR13377; 1.
DR   Pfam; PF08551; DUF1751; 1.
DR   SUPFAM; SSF144091; SSF144091; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Membrane; Phosphoprotein; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..351
FT                   /note="Transmembrane protein 115"
FT                   /id="PRO_0000355564"
FT   TOPO_DOM        1..19
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        20..40
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        41..97
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        98..118
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..126
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        127..147
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        148..165
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        166..186
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        187..351
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   REGION          1..205
FT                   /note="Mediates homooligomerization"
FT                   /evidence="ECO:0000250|UniProtKB:Q12893"
FT   REGION          206..229
FT                   /note="Mediates localization to the Golgi"
FT                   /evidence="ECO:0000250|UniProtKB:Q12893"
FT   REGION          300..351
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         329
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q12893"
SQ   SEQUENCE   351 AA;  38139 MW;  C7F111ABF2985FEB CRC64;
     MQRALPGARQ HLGAILSSAS VVVKALCAAV LFLYLLSFAV DTGCLAVTPG YLFPPNFWIW
     TLATHGLMEQ HVWDVAISLA TVVVAGRLLE PLWGALELLI FFSVVNVSVG LLGAFAYLLT
     YMASFNLVYL FTVRIHGALG FLGGVLVALK QTMGDCVVLR VPQVRVSVVP MLLLGLLLLL
     RLATLLQSPA LASYGFGLIS SWVYLRFYQR HSRGRGDMAD HFAFATFFPE ILQPVVGLLA
     NLVHGLLVKV KICQKTVKRY DVGAPSSITI SLPGTDPQDA ERRRQLALKA LNERLKRVED
     QSVWPSMDDD EEEAGAKVDS PMPSDKAPTL PGKGAVPESS LITFEAAPPT L