TM115_MOUSE
ID TM115_MOUSE Reviewed; 350 AA.
AC Q9WUH1; Q91VT6;
DT 01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Transmembrane protein 115 {ECO:0000305};
DE AltName: Full=Protein PL6 homolog {ECO:0000305};
GN Name=Tmem115 {ECO:0000312|MGI:MGI:1930765};
GN Synonyms=Pl6 {ECO:0000312|EMBL:AAD24193.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RA Ivanov S., Minna J., Lerman M.I.;
RT "Mouse ortholog of the human gene PL6.";
RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May play a role in retrograde transport of proteins from the
CC Golgi to the endoplasmic reticulum. May indirectly play a role in
CC protein glycosylation in the Golgi. {ECO:0000250|UniProtKB:Q12893}.
CC -!- SUBUNIT: Homooligomer. Interacts with COPB1. May interact with LMAN1.
CC Interacts with the COG complex; probably through COG3.
CC {ECO:0000250|UniProtKB:Q12893}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane
CC {ECO:0000250|UniProtKB:Q12893}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q12893}.
CC -!- SIMILARITY: Belongs to the TMEM115 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH09099.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF134238; AAD24193.1; -; mRNA.
DR EMBL; BC009099; AAH09099.1; ALT_INIT; mRNA.
DR EMBL; BC019473; AAH19473.1; -; mRNA.
DR CCDS; CCDS23490.1; -.
DR RefSeq; NP_062678.1; NM_019704.2.
DR AlphaFoldDB; Q9WUH1; -.
DR BioGRID; 207950; 3.
DR STRING; 10090.ENSMUSP00000010189; -.
DR iPTMnet; Q9WUH1; -.
DR PhosphoSitePlus; Q9WUH1; -.
DR SwissPalm; Q9WUH1; -.
DR EPD; Q9WUH1; -.
DR jPOST; Q9WUH1; -.
DR MaxQB; Q9WUH1; -.
DR PaxDb; Q9WUH1; -.
DR PRIDE; Q9WUH1; -.
DR ProteomicsDB; 259521; -.
DR Antibodypedia; 3346; 117 antibodies from 20 providers.
DR DNASU; 56395; -.
DR Ensembl; ENSMUST00000010189; ENSMUSP00000010189; ENSMUSG00000010045.
DR GeneID; 56395; -.
DR KEGG; mmu:56395; -.
DR UCSC; uc009rlk.1; mouse.
DR CTD; 11070; -.
DR MGI; MGI:1930765; Tmem115.
DR VEuPathDB; HostDB:ENSMUSG00000010045; -.
DR eggNOG; KOG2890; Eukaryota.
DR GeneTree; ENSGT00390000002470; -.
DR HOGENOM; CLU_043563_2_0_1; -.
DR InParanoid; Q9WUH1; -.
DR OMA; ICEKICC; -.
DR OrthoDB; 1156492at2759; -.
DR PhylomeDB; Q9WUH1; -.
DR TreeFam; TF315100; -.
DR Reactome; R-MMU-6807878; COPI-mediated anterograde transport.
DR BioGRID-ORCS; 56395; 5 hits in 72 CRISPR screens.
DR PRO; PR:Q9WUH1; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q9WUH1; protein.
DR Bgee; ENSMUSG00000010045; Expressed in saccule of membranous labyrinth and 252 other tissues.
DR ExpressionAtlas; Q9WUH1; baseline and differential.
DR Genevisible; Q9WUH1; MM.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0032580; C:Golgi cisterna membrane; ISS:UniProtKB.
DR GO; GO:0017119; C:Golgi transport complex; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; ISS:UniProtKB.
DR InterPro; IPR035952; Rhomboid-like_sf.
DR InterPro; IPR013861; TMEM115/Pdh1/Rbl19.
DR PANTHER; PTHR13377; PTHR13377; 1.
DR Pfam; PF08551; DUF1751; 1.
DR SUPFAM; SSF144091; SSF144091; 1.
PE 1: Evidence at protein level;
KW Golgi apparatus; Membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..350
FT /note="Transmembrane protein 115"
FT /id="PRO_0000058452"
FT TOPO_DOM 1..19
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 20..40
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 41..97
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 98..118
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..126
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 127..147
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..165
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 166..186
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 187..350
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT REGION 1..205
FT /note="Mediates homooligomerization"
FT /evidence="ECO:0000250|UniProtKB:Q12893"
FT REGION 206..229
FT /note="Mediates localization to the Golgi"
FT /evidence="ECO:0000250|UniProtKB:Q12893"
FT REGION 299..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 329
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q12893"
SQ SEQUENCE 350 AA; 38099 MW; 9D8B9B164CA2842D CRC64;
MQRALPGARQ HLGAILASAS VVVKALCAVV LFLYLLSFAV DTGCLAVTPG YLFPPNFWIW
TLATHGLMEQ HVWDVAISLA TVVVAGRLLE PLWGALELLI FFSVVNVSVG LLGALAYLLT
YMASFNLVYL FTIRIHGALG FLGGVLVALK QTMGDCVVLR VPQVRVSVVP MLLLALLLLL
RLATLLQSPA LASYGFGLLS SWVYLRFYQR HSRGRGDMAD HFAFATFFPE ILQPVVGLLA
NLVHGLLVKV KICQKTVKRY DVGAPSSITI SLPGTDPQDA ERRRQLALKA LNERLKRVED
QSAWPSMDDD EEEAGAKTDS PLPLEEASTP PGKVTVPESS LITLETAPLL
