TM115_YEAST
ID TM115_YEAST Reviewed; 342 AA.
AC Q12239; D6W1W0;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Transmembrane protein 115 homolog {ECO:0000305};
GN OrderedLocusNames=YOL107W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=7502582; DOI=10.1002/yea.320111108;
RA Vandenbol M., Durand P., Portetelle D., Hilger F.;
RT "Sequence analysis of a 44 kb DNA fragment of yeast chromosome XV including
RT the Ty1-H3 retrotransposon, the suf1(+) frameshift suppressor gene for
RT tRNA-Gly, the yeast transfer RNA-Thr-1a and a delta element.";
RL Yeast 11:1069-1075(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169874;
RA Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
RA Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
RA Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
RA Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
RA Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
RA Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
RA Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
RA Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
RA Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
RA Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
RA Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
RA Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
RA Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
RA Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
RA Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
RA Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
RL Nature 387:98-102(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [6]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- FUNCTION: May play a role in retrograde transport of proteins from the
CC Golgi to the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q12893}.
CC -!- SUBUNIT: Homooligomer. {ECO:0000250|UniProtKB:Q12893}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:14562095}.
CC -!- MISCELLANEOUS: Present with 1630 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the TMEM115 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z48149; CAA88154.1; -; Genomic_DNA.
DR EMBL; Z74849; CAA99126.1; -; Genomic_DNA.
DR EMBL; BK006948; DAA10676.1; -; Genomic_DNA.
DR PIR; S51891; S51891.
DR RefSeq; NP_014534.1; NM_001183361.1.
DR AlphaFoldDB; Q12239; -.
DR BioGRID; 34294; 35.
DR DIP; DIP-4218N; -.
DR IntAct; Q12239; 2.
DR MINT; Q12239; -.
DR STRING; 4932.YOL107W; -.
DR PaxDb; Q12239; -.
DR PRIDE; Q12239; -.
DR EnsemblFungi; YOL107W_mRNA; YOL107W; YOL107W.
DR GeneID; 854043; -.
DR KEGG; sce:YOL107W; -.
DR SGD; S000005467; YOL107W.
DR VEuPathDB; FungiDB:YOL107W; -.
DR eggNOG; KOG2890; Eukaryota.
DR GeneTree; ENSGT00390000002470; -.
DR HOGENOM; CLU_043563_1_0_1; -.
DR InParanoid; Q12239; -.
DR OMA; FACLFPD; -.
DR BioCyc; YEAST:G3O-33504-MON; -.
DR PRO; PR:Q12239; -.
DR Proteomes; UP000002311; Chromosome XV.
DR RNAct; Q12239; protein.
DR GO; GO:0005794; C:Golgi apparatus; HDA:SGD.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IBA:GO_Central.
DR InterPro; IPR013861; TMEM115/Pdh1/Rbl19.
DR PANTHER; PTHR13377; PTHR13377; 1.
DR Pfam; PF08551; DUF1751; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..342
FT /note="Transmembrane protein 115 homolog"
FT /id="PRO_0000235931"
FT TOPO_DOM 1..21
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 22..42
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 43..121
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 122..142
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 143..159
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 160..180
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 181..207
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 208..228
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 229..342
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT CARBOHYD 114
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 342 AA; 39742 MW; 75C352C4CE35DC57 CRC64;
MQYSSRFLEL NIPDSFLNIN KIPDATKFIT VTYICLTATL FCIRRSLYNK LVLEDPNLDY
NLITSPLLQM VPSQIWRYPT SLVLSNFIDT KAWKVVVNLL NLIIGGSFIE RNWNSSKEMF
KFIIVLGSLT NVLIIMLTLL VSFFSNKVRL DIPLDGNYTI LIGFPIIYRQ LLPETTIIHL
KTPQFLAKNF RFKLLPIFVM FTMTVTQIIW FHHFAQLFSI WVTFFASWSY LRFFQKLAPL
NCPSLPTTNS QGGQEILVGD ASDTFQLIYF FPDLIKPILR PIFNFIYNVV VVKFKVIKPF
HDIDIDIGNT IAESRGAKKI MTVEERRRQL ALQVLEERMV NP
