TM116_DANRE
ID TM116_DANRE Reviewed; 361 AA.
AC A2BGS3;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Transmembrane protein 116;
GN Name=tmem116; ORFNames=si:ch211-157p22.10;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; BX510999; CAM13327.1; -; Genomic_DNA.
DR EMBL; BC154518; AAI54519.1; -; mRNA.
DR RefSeq; NP_001108179.1; NM_001114707.1.
DR AlphaFoldDB; A2BGS3; -.
DR SMR; A2BGS3; -.
DR STRING; 7955.ENSDARP00000100247; -.
DR PaxDb; A2BGS3; -.
DR Ensembl; ENSDART00000112692; ENSDARP00000100247; ENSDARG00000077155.
DR GeneID; 100003849; -.
DR KEGG; dre:100003849; -.
DR CTD; 89894; -.
DR ZFIN; ZDB-GENE-060526-53; tmem116.
DR eggNOG; KOG0370; Eukaryota.
DR GeneTree; ENSGT00390000003209; -.
DR HOGENOM; CLU_057808_0_0_1; -.
DR InParanoid; A2BGS3; -.
DR OMA; VIDYTCH; -.
DR OrthoDB; 1592724at2759; -.
DR PhylomeDB; A2BGS3; -.
DR TreeFam; TF330947; -.
DR PRO; PR:A2BGS3; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 5.
DR Bgee; ENSDARG00000077155; Expressed in zone of skin and 16 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR022343; GCR1-cAMP_receptor.
DR PRINTS; PR02001; GCR1CAMPR.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..361
FT /note="Transmembrane protein 116"
FT /id="PRO_0000360407"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 261..281
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 361 AA; 40414 MW; A0824972DEFC0422 CRC64;
MDIFGENKTQ MNTTTPTENW TSVYSIVRWI QMTMAVLSIL GAGSIILYAA FQRLVKKPEV
LPLFLLSLTD LLLALSWLCG GLLFTQSCNS YATCYNLHIV EQTLYMASFF YTLHYVWVLY
TGLNGKYHRR LNGFPAEAAR TRNCRCLGPV LSCLLPLLLT APVFVAGNVF QCYTNFTQPY
RCLLMHTGAV YLTSSASPEL TACSIIQEYC MAIFLGTFLI TIVGMSIFMG KARSLYKRVV
TSQGFFGGSH WTTLRLLERR MVLYPSAFFF CWGPALLLAT MMLVKPDVIE GKMGVALYIL
QAFTSASQGL LNCLVYGWTQ KHFRSLSSST VRDANTQTPL LRSQKPNYAA LHSAASLTNF
V
