TM116_HUMAN
ID TM116_HUMAN Reviewed; 245 AA.
AC Q8NCL8; G3V1W7; G5E985; Q6NSH5; Q8IZ66;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Transmembrane protein 116;
GN Name=TMEM116;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Mammary gland;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8NCL8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NCL8-2; Sequence=VSP_046988;
CC Name=3;
CC IsoId=Q8NCL8-3; Sequence=VSP_046987;
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DR EMBL; AK074648; BAC11112.1; -; mRNA.
DR EMBL; AC004024; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC073575; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471054; EAW97987.1; -; Genomic_DNA.
DR EMBL; CH471054; EAW97988.1; -; Genomic_DNA.
DR EMBL; BC022360; AAH22360.2; -; mRNA.
DR EMBL; BC048796; AAH48796.1; -; mRNA.
DR EMBL; BC070135; AAH70135.1; -; mRNA.
DR CCDS; CCDS55886.1; -. [Q8NCL8-3]
DR CCDS; CCDS55887.1; -. [Q8NCL8-2]
DR CCDS; CCDS9157.1; -. [Q8NCL8-1]
DR RefSeq; NP_001180382.1; NM_001193453.1. [Q8NCL8-3]
DR RefSeq; NP_001180460.1; NM_001193531.1. [Q8NCL8-2]
DR RefSeq; NP_001281243.1; NM_001294314.1. [Q8NCL8-1]
DR RefSeq; NP_612350.1; NM_138341.2. [Q8NCL8-1]
DR RefSeq; XP_011537248.1; XM_011538946.1.
DR RefSeq; XP_011537249.1; XM_011538947.1. [Q8NCL8-3]
DR RefSeq; XP_011537251.1; XM_011538949.2. [Q8NCL8-2]
DR RefSeq; XP_011537259.1; XM_011538957.1. [Q8NCL8-1]
DR RefSeq; XP_016875679.1; XM_017020190.1. [Q8NCL8-1]
DR RefSeq; XP_016875680.1; XM_017020191.1.
DR RefSeq; XP_016875681.1; XM_017020192.1. [Q8NCL8-1]
DR AlphaFoldDB; Q8NCL8; -.
DR SMR; Q8NCL8; -.
DR BioGRID; 124641; 9.
DR STRING; 9606.ENSP00000447731; -.
DR iPTMnet; Q8NCL8; -.
DR PhosphoSitePlus; Q8NCL8; -.
DR BioMuta; TMEM116; -.
DR DMDM; 74730154; -.
DR jPOST; Q8NCL8; -.
DR PaxDb; Q8NCL8; -.
DR PeptideAtlas; Q8NCL8; -.
DR PRIDE; Q8NCL8; -.
DR ProteomicsDB; 32461; -.
DR ProteomicsDB; 33863; -.
DR ProteomicsDB; 72904; -. [Q8NCL8-1]
DR Antibodypedia; 50816; 22 antibodies from 12 providers.
DR DNASU; 89894; -.
DR Ensembl; ENST00000355445.7; ENSP00000347620.2; ENSG00000198270.13. [Q8NCL8-3]
DR Ensembl; ENST00000550831.7; ENSP00000450377.1; ENSG00000198270.13. [Q8NCL8-1]
DR Ensembl; ENST00000552374.7; ENSP00000447731.1; ENSG00000198270.13. [Q8NCL8-2]
DR GeneID; 89894; -.
DR KEGG; hsa:89894; -.
DR MANE-Select; ENST00000552374.7; ENSP00000447731.1; NM_001193531.2; NP_001180460.1. [Q8NCL8-2]
DR UCSC; uc001ttd.3; human. [Q8NCL8-1]
DR CTD; 89894; -.
DR DisGeNET; 89894; -.
DR GeneCards; TMEM116; -.
DR HGNC; HGNC:25084; TMEM116.
DR HPA; ENSG00000198270; Tissue enhanced (parathyroid).
DR neXtProt; NX_Q8NCL8; -.
DR OpenTargets; ENSG00000198270; -.
DR PharmGKB; PA143485637; -.
DR VEuPathDB; HostDB:ENSG00000198270; -.
DR eggNOG; KOG0370; Eukaryota.
DR GeneTree; ENSGT00390000003209; -.
DR HOGENOM; CLU_057808_1_0_1; -.
DR InParanoid; Q8NCL8; -.
DR OMA; VIDYTCH; -.
DR OrthoDB; 1592724at2759; -.
DR PhylomeDB; Q8NCL8; -.
DR TreeFam; TF330947; -.
DR PathwayCommons; Q8NCL8; -.
DR BioGRID-ORCS; 89894; 10 hits in 1083 CRISPR screens.
DR ChiTaRS; TMEM116; human.
DR GenomeRNAi; 89894; -.
DR Pharos; Q8NCL8; Tdark.
DR PRO; PR:Q8NCL8; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q8NCL8; protein.
DR Bgee; ENSG00000198270; Expressed in olfactory segment of nasal mucosa and 159 other tissues.
DR ExpressionAtlas; Q8NCL8; baseline and differential.
DR Genevisible; Q8NCL8; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..245
FT /note="Transmembrane protein 116"
FT /id="PRO_0000251195"
FT TRANSMEM 24..44
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..13
FT /note="MKHTQSGQSTSPL -> MATLSVIGSSSLIAYAVFHNIQKSPEIRPLFYLSF
FT CDLLLGLCWLTETLLYGASVANKDIICYNLQAVGQ (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_046987"
FT VAR_SEQ 1
FT /note="M -> MATLSVIGSSSLIAYAVFHNIQKSPEIRPLFYLSFCDLLLGLCWLTE
FT TLLYGASVANKDIICYNLQAVGQIFYISSFLYTVNYIWYLYTELRM (in isoform
FT 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_046988"
FT VARIANT 22
FT /note="C -> G (in dbSNP:rs3752630)"
FT /id="VAR_027659"
FT CONFLICT 17
FT /note="Y -> F (in Ref. 4; AAH70135)"
FT /evidence="ECO:0000305"
FT CONFLICT 170
FT /note="H -> R (in Ref. 4; AAH70135)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 245 AA; 27464 MW; 07D30AE24CDD0345 CRC64;
MKHTQSGQST SPLVIDYTCR VCQMAFVFSS LIPLLLMTPV FCLGNTSECF QNFSQSHKCI
LMHSPPSAMA ELPPSANTSV CSTLYFYGIA IFLGSFVLSL LTIMVLLIRA QTLYKKFVKS
TGFLGSEQWA VIHIVDQRVR FYPVAFFCCW GPAVILMIIK LTKPQDTKLH MALYVLQALT
ATSQGLLNCG VYGWTQHKFH QLKQEARRDA DTQTPLLCSQ KRFYSRGLNS LESTLTFPAS
TSTIF
