ID   TM117_DANRE             Reviewed;         401 AA.
AC   Q7ZVW1;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Transmembrane protein 117;
GN   Name=tmem117; ORFNames=zgc:55574;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in endoplasmic reticulum (ER) stress-induced
CC       cell death pathway. {ECO:0000250|UniProtKB:Q9H0C3}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9H0C3};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM117 family. {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-21 is the initiator.
CC       {ECO:0000305}.
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DR   EMBL; BC045388; AAH45388.1; -; mRNA.
DR   RefSeq; NP_998619.1; NM_213454.1.
DR   AlphaFoldDB; Q7ZVW1; -.
DR   STRING; 7955.ENSDARP00000112036; -.
DR   PaxDb; Q7ZVW1; -.
DR   GeneID; 406763; -.
DR   KEGG; dre:406763; -.
DR   CTD; 84216; -.
DR   ZFIN; ZDB-GENE-040426-2809; tmem117.
DR   eggNOG; ENOG502QXR1; Eukaryota.
DR   InParanoid; Q7ZVW1; -.
DR   OrthoDB; 801372at2759; -.
DR   PhylomeDB; Q7ZVW1; -.
DR   PRO; PR:Q7ZVW1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; ISS:UniProtKB.
DR   InterPro; IPR029370; TMEM117.
DR   PANTHER; PTHR31226; PTHR31226; 1.
DR   Pfam; PF15113; TMEM117; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..401
FT                   /note="Transmembrane protein 117"
FT                   /id="PRO_0000360402"
FT   TOPO_DOM        1..37
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H0C3"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        59..81
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H0C3"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        103..131
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H0C3"
FT   TRANSMEM        132..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        153..176
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H0C3"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        198..219
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H0C3"
FT   TRANSMEM        220..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        241..260
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H0C3"
FT   TRANSMEM        261..281
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        282..316
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H0C3"
FT   TRANSMEM        317..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        338..401
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H0C3"
FT   CARBOHYD        170
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        374
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        392
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        396
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   401 AA;  47573 MW;  2DF1BC6F2365997B CRC64;
     MSSQSLHDCL RGRCLGVLRR MEIIGRFRYY FQHPWSRLLV SYLVTFFNFL IFAEDPVSHS
     QKEAHMSVVG NCFSFIISKY PAGFWSVLKV LLWVLAIICG LIAGKFIFHR RLFGRVLRLK
     MFREDHGSWM TMFFSTILSL FIFSHIYNLL LLMSVRMRPY MVTEYMGIRN ESFMKMAAVG
     TWMGDFVTAW MVTDMMLQDT HYPDWGRTAR HLWRQGHNRI VLFWTVLICL TSVVVLVIST
     DWIRWDNLNR GFLPSDEVSR AFLASFILVF DLLIVMQDWE FPHFMGDLDM NLPGLSTTQL
     KIRLPVCKRI FKEEYHIHIT GKWFNYGIIF LVLILDLNMW KNQIFYKPYE YGQYVGPGEK
     IYTVEDPDTL QDFNRSMLTW EWRSTNIDPR TNQTFNQSNA I