TM117_MOUSE
ID TM117_MOUSE Reviewed; 514 AA.
AC Q8BH18; Q8C6X8;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Transmembrane protein 117;
GN Name=Tmem117;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, Head, and Heart;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-453, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Involved in endoplasmic reticulum (ER) stress-induced cell
CC death pathway. {ECO:0000250|UniProtKB:Q9H0C3}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9H0C3};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the TMEM117 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC35210.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK047437; BAC33060.1; -; mRNA.
DR EMBL; AK048597; BAC33384.1; -; mRNA.
DR EMBL; AK052935; BAC35210.1; ALT_INIT; mRNA.
DR EMBL; BC051178; AAH51178.1; -; mRNA.
DR CCDS; CCDS27774.1; -.
DR RefSeq; NP_848904.1; NM_178789.4.
DR AlphaFoldDB; Q8BH18; -.
DR STRING; 10090.ENSMUSP00000079038; -.
DR GlyGen; Q8BH18; 2 sites.
DR iPTMnet; Q8BH18; -.
DR PhosphoSitePlus; Q8BH18; -.
DR PaxDb; Q8BH18; -.
DR PRIDE; Q8BH18; -.
DR ProteomicsDB; 259522; -.
DR Antibodypedia; 25193; 93 antibodies from 18 providers.
DR DNASU; 320709; -.
DR Ensembl; ENSMUST00000080141; ENSMUSP00000079038; ENSMUSG00000063296.
DR GeneID; 320709; -.
DR KEGG; mmu:320709; -.
DR UCSC; uc007xjn.1; mouse.
DR CTD; 84216; -.
DR MGI; MGI:2444580; Tmem117.
DR VEuPathDB; HostDB:ENSMUSG00000063296; -.
DR eggNOG; ENOG502QXR1; Eukaryota.
DR GeneTree; ENSGT00390000013052; -.
DR HOGENOM; CLU_047657_0_0_1; -.
DR InParanoid; Q8BH18; -.
DR OMA; GSMGAYI; -.
DR OrthoDB; 801372at2759; -.
DR PhylomeDB; Q8BH18; -.
DR TreeFam; TF336012; -.
DR BioGRID-ORCS; 320709; 1 hit in 70 CRISPR screens.
DR ChiTaRS; Tmem117; mouse.
DR PRO; PR:Q8BH18; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q8BH18; protein.
DR Bgee; ENSMUSG00000063296; Expressed in otolith organ and 158 other tissues.
DR Genevisible; Q8BH18; MM.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; ISS:UniProtKB.
DR InterPro; IPR029370; TMEM117.
DR PANTHER; PTHR31226; PTHR31226; 1.
DR Pfam; PF15113; TMEM117; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Glycoprotein; Membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..514
FT /note="Transmembrane protein 117"
FT /id="PRO_0000251205"
FT TOPO_DOM 1..15
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q9H0C3"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 37..65
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q9H0C3"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 87..110
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q9H0C3"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 132..154
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q9H0C3"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 176..198
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q9H0C3"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..239
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q9H0C3"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..295
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q9H0C3"
FT TRANSMEM 296..316
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 317..394
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q9H0C3"
FT TRANSMEM 395..415
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 416..514
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q9H0C3"
FT REGION 430..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..448
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 453
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CARBOHYD 353
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000250|UniProtKB:Q9H0C3"
FT CARBOHYD 371
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000250|UniProtKB:Q9H0C3"
SQ SEQUENCE 514 AA; 60356 MW; 5912873BC472C8B8 CRC64;
MGKDFRYYFQ HPWSRMIVAY LVIFFNFLIF AEDPVSHSQT EANVIVVGNC FSFVTNKYPR
GVGWRILKVL LWLLAILIGL IAGKFLFHQR LFGQLLRLKM FREDHGSWMT MFFSTILFLF
IFSHIYNTIL LMDGNMGAYL ITDYMGIRNE SFMKLAAVGT WMGDFVTAWM VTDMMLQDKP
YPDWGKSARA FWKKGNVRII LFWTVLFTLT SVVVLVITTD WISWDKLNRG FLPSDEVSRA
FLASFILVFD LLIVMQDWEF PHFMGDVDVN LPGLHTPHMQ FKIPFFQKIF KEEYRIHITG
KWFNYGIIFL VLILDLNMWK NQIFYKPHEY GQYIGPGQKI YTVKDSESLK DLNRTKLSWE
WRSNHTNPQT NKTYVEGDMF LHSRFIGASL DVKCLAFVPS LIAFVWFGFF IWFFGRFLKN
EQGMENQDKT YTRMKRKSPS EHSKDMGITR ENTQVSVEDP LNDPALVCIR SDFNEIVYKS
SHLTSENLSL HLKESTSEVE AEQEPAASQR MRTN
