ID   BST14_CAEEL             Reviewed;         405 AA.
AC   Q19978;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 3.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Bestrophin homolog 14;
GN   Name=best-14; ORFNames=F32G8.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the bestrophin family. {ECO:0000305}.
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DR   EMBL; Z72509; CAA96648.3; -; Genomic_DNA.
DR   PIR; H89192; H89192.
DR   PIR; T21670; T21670.
DR   RefSeq; NP_505708.2; NM_073307.4.
DR   AlphaFoldDB; Q19978; -.
DR   SMR; Q19978; -.
DR   BioGRID; 44500; 3.
DR   STRING; 6239.F32G8.4; -.
DR   EPD; Q19978; -.
DR   PaxDb; Q19978; -.
DR   PeptideAtlas; Q19978; -.
DR   EnsemblMetazoa; F32G8.4.1; F32G8.4.1; WBGene00009340.
DR   GeneID; 179471; -.
DR   KEGG; cel:CELE_F32G8.4; -.
DR   UCSC; F32G8.4; c. elegans.
DR   CTD; 179471; -.
DR   WormBase; F32G8.4; CE37903; WBGene00009340; best-14.
DR   eggNOG; KOG3547; Eukaryota.
DR   HOGENOM; CLU_018069_0_1_1; -.
DR   InParanoid; Q19978; -.
DR   OMA; CEIGSQY; -.
DR   OrthoDB; 279144at2759; -.
DR   PhylomeDB; Q19978; -.
DR   Reactome; R-CEL-2672351; Stimuli-sensing channels.
DR   PRO; PR:Q19978; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00009340; Expressed in larva and 3 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005254; F:chloride channel activity; IBA:GO_Central.
DR   InterPro; IPR000615; Bestrophin.
DR   InterPro; IPR021134; Bestrophin/UPF0187.
DR   PANTHER; PTHR10736; PTHR10736; 1.
DR   Pfam; PF01062; Bestrophin; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..405
FT                   /note="Bestrophin homolog 14"
FT                   /id="PRO_0000143131"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        223..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        256..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   405 AA;  47349 MW;  249E31368271552A CRC64;
     MTISYDEEFS SLMLRWRGSI WKAVLKDLIG FYIAYYIVLA FQWYLLDEKG KEYFTGWIMW
     CEIGAQYIPL SFLLGFFVSL IVARWWEQFN CISWPDKMMI MVSACLPGNE NMVVRQTIAR
     WSSLQAAIAW SGVSVKTLKR FPTERHMVAS KLMTEEEYDL YMNTDAPHGK WFIPILWIVN
     LIKKQKQKGI IDSIQMDMLL KQVYSYRDGF AMLFVYDWIK IPLVYTQVVA IATYGYFFIC
     LIGRQPKLDQ RSMEKEITIL FPIFTTFQML FYLGWLKVGQ YLMNPFGEDD DDFELNYVLD
     RNTAIAHMMA SELSDQLPSI GAPMVPAVPH TRASFKIQDV IPKSHLAGFK LSEAEMKLIK
     PEDLEEHERL MEETKVTNRQ RLGTLVRALE KKSRTNATIN EDDEE