ID   BST15_CAEEL             Reviewed;         525 AA.
AC   Q21973;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   23-APR-2003, sequence version 2.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Bestrophin homolog 15;
DE   AltName: Full=Bestrophin-1;
DE            Short=ceBest1;
GN   Name=best-15; ORFNames=R13.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBUNIT.
RX   PubMed=11904445; DOI=10.1073/pnas.052692999;
RA   Sun H., Tsunenari T., Yau K.-W., Nathans J.;
RT   "The vitelliform macular dystrophy protein defines a new family of chloride
RT   channels.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:4008-4013(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Forms chloride channels. {ECO:0000269|PubMed:11904445}.
CC   -!- SUBUNIT: Forms oligomers. {ECO:0000269|PubMed:11904445}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the bestrophin family. {ECO:0000305}.
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DR   EMBL; AY515708; AAR99658.1; -; mRNA.
DR   EMBL; Z73105; CAA97442.2; -; Genomic_DNA.
DR   PIR; T24210; T24210.
DR   RefSeq; NP_502007.2; NM_069606.6.
DR   AlphaFoldDB; Q21973; -.
DR   SMR; Q21973; -.
DR   BioGRID; 43076; 1.
DR   STRING; 6239.R13.3; -.
DR   TCDB; 1.A.46.1.3; the anion channel-forming bestrophin (bestrophin) family.
DR   PaxDb; Q21973; -.
DR   PeptideAtlas; Q21973; -.
DR   EnsemblMetazoa; R13.3.1; R13.3.1; WBGene00011258.
DR   GeneID; 177975; -.
DR   KEGG; cel:CELE_R13.3; -.
DR   UCSC; R13.3; c. elegans.
DR   CTD; 177975; -.
DR   WormBase; R13.3; CE32919; WBGene00011258; best-15.
DR   eggNOG; KOG3547; Eukaryota.
DR   HOGENOM; CLU_018069_7_2_1; -.
DR   InParanoid; Q21973; -.
DR   OMA; QAPSEIN; -.
DR   OrthoDB; 279144at2759; -.
DR   PhylomeDB; Q21973; -.
DR   Reactome; R-CEL-2672351; Stimuli-sensing channels.
DR   PRO; PR:Q21973; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00011258; Expressed in adult organism and 2 other tissues.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005254; F:chloride channel activity; IBA:GO_Central.
DR   InterPro; IPR000615; Bestrophin.
DR   InterPro; IPR021134; Bestrophin/UPF0187.
DR   PANTHER; PTHR10736; PTHR10736; 1.
DR   Pfam; PF01062; Bestrophin; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Chloride; Chloride channel; Ion channel; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..525
FT                   /note="Bestrophin homolog 15"
FT                   /id="PRO_0000143123"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   525 AA;  60485 MW;  9E0A90D9523C3229 CRC64;
     MTVNYNLDVS SASIFSFLRL QLRWKGSIWK YLLKELFMFI IAFITVSSVY RSNLIIGEKT
     RKIWDNFAAL FDQNMDFIPL TFMLGFFVTI IVRRWNDIFA NLGWVENTAI TVANYIRGTD
     DRTRMIRRNV IRYMVLAQVL VFRDCSIQVR KRFPTMESIV SAGFMLEHEK EALDNVQCGK
     LQKYFVPIQW STGLLVDARA EGKIAADLLM NEIGKHIIEF RKMLALLSNY DWVPIPLAYP
     QVVFLAVRSY FFMALIARQS VLLDGKEPEQ PSILYPTVPF VMSILQFIFV VGWMKVAESM
     INPLGEDDDD FECNYLLDRN LMIGLCIVDD NYNRTPSVEK DAFWCADVEP LYSVETAMIP
     KNPQIGSAAN YDVKVDEEEV MMMPHMDDVD LFDFESTNNL IPRKTFSVIS IQRPFGSRAS
     LASRKRSMMF DQLRGRIAKK QHRSNMFQNS VSQASLHYFE SQAPSEINLS TLEMTAPKRK
     SSTGKLGSMN VAEEQHKLSA EVLPIVIEED EERSKMLEKD KNKNA