TM11F_HUMAN
ID TM11F_HUMAN Reviewed; 438 AA.
AC Q6ZWK6; A8MXX2;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Transmembrane protease serine 11F;
DE EC=3.4.21.-;
DE AltName: Full=Airway trypsin-like protease 4;
GN Name=TMPRSS11F; Synonyms=HATL4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
CC -!- FUNCTION: Probable serine protease. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the peptidase S1 family. {ECO:0000255|PROSITE-
CC ProRule:PRU00274}.
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DR EMBL; AK122625; BAC85495.1; -; mRNA.
DR EMBL; AC096727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC107054; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS3520.1; -.
DR RefSeq; NP_997290.2; NM_207407.2.
DR AlphaFoldDB; Q6ZWK6; -.
DR SMR; Q6ZWK6; -.
DR BioGRID; 133038; 1.
DR IntAct; Q6ZWK6; 1.
DR STRING; 9606.ENSP00000348639; -.
DR MEROPS; S01.321; -.
DR iPTMnet; Q6ZWK6; -.
DR PhosphoSitePlus; Q6ZWK6; -.
DR BioMuta; TMPRSS11F; -.
DR DMDM; 206729902; -.
DR MassIVE; Q6ZWK6; -.
DR PaxDb; Q6ZWK6; -.
DR PeptideAtlas; Q6ZWK6; -.
DR PRIDE; Q6ZWK6; -.
DR Antibodypedia; 12702; 37 antibodies from 14 providers.
DR DNASU; 389208; -.
DR Ensembl; ENST00000356291.3; ENSP00000348639.2; ENSG00000198092.6.
DR GeneID; 389208; -.
DR KEGG; hsa:389208; -.
DR MANE-Select; ENST00000356291.3; ENSP00000348639.2; NM_207407.2; NP_997290.2.
DR UCSC; uc003hdt.2; human.
DR CTD; 389208; -.
DR DisGeNET; 389208; -.
DR GeneCards; TMPRSS11F; -.
DR HGNC; HGNC:29994; TMPRSS11F.
DR HPA; ENSG00000198092; Group enriched (esophagus, lymphoid tissue, skin, vagina).
DR neXtProt; NX_Q6ZWK6; -.
DR OpenTargets; ENSG00000198092; -.
DR PharmGKB; PA142670730; -.
DR VEuPathDB; HostDB:ENSG00000198092; -.
DR eggNOG; KOG3627; Eukaryota.
DR GeneTree; ENSGT00940000161680; -.
DR HOGENOM; CLU_006842_19_0_1; -.
DR InParanoid; Q6ZWK6; -.
DR OMA; SQWIATF; -.
DR OrthoDB; 1314811at2759; -.
DR PhylomeDB; Q6ZWK6; -.
DR TreeFam; TF351684; -.
DR PathwayCommons; Q6ZWK6; -.
DR SignaLink; Q6ZWK6; -.
DR BioGRID-ORCS; 389208; 12 hits in 1066 CRISPR screens.
DR ChiTaRS; TMPRSS11F; human.
DR GenomeRNAi; 389208; -.
DR Pharos; Q6ZWK6; Tdark.
DR PRO; PR:Q6ZWK6; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q6ZWK6; protein.
DR Bgee; ENSG00000198092; Expressed in lower esophagus mucosa and 24 other tissues.
DR GO; GO:0009986; C:cell surface; IDA:MGI.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0033561; P:regulation of water loss via skin; IEA:Ensembl.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.40.10.10; -; 2.
DR Gene3D; 3.30.70.960; -; 1.
DR InterPro; IPR017329; Pept_S1A_HAT/DESC1.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR Pfam; PF01390; SEA; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PIRSF; PIRSF037941; TMPRSS11ABCDE; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF50494; SSF50494; 1.
DR SUPFAM; SSF82671; SSF82671; 1.
DR PROSITE; PS50024; SEA; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Hydrolase; Membrane; Protease; Reference proteome;
KW Serine protease; Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..438
FT /note="Transmembrane protease serine 11F"
FT /id="PRO_0000299322"
FT TOPO_DOM 1..32
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..438
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 57..175
FT /note="SEA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT DOMAIN 206..437
FT /note="Peptidase S1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT ACT_SITE 248
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 293
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 389
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT DISULFID 233..249
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT DISULFID 358..374
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT DISULFID 385..413
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT VARIANT 4
FT /note="A -> T (in dbSNP:rs10030708)"
FT /id="VAR_034800"
FT VARIANT 124
FT /note="D -> N (in dbSNP:rs1438391)"
FT /id="VAR_046636"
FT CONFLICT 163
FT /note="I -> L (in Ref. 1; BAC85495)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 438 AA; 49410 MW; F36C3D3EFB4D1E9A CRC64;
MMYAPVEFSE AEFSRAEYQR KQQFWDSVRL ALFTLAIVAI IGIAIGIVTH FVVEDDKSFY
YLASFKVTNI KYKENYGIRS SREFIERSHQ IERMMSRIFR HSSVGGRFIK SHVIKLSPDE
QGVDILIVLI FRYPSTDSAE QIKKKIEKAL YQSLKTKQLS LTINKPSFRL TPIDSKKMRN
LLNSRCGIRM TSSNMPLPAS SSTQRIVQGR ETAMEGEWPW QASLQLIGSG HQCGASLISN
TWLLTAAHCF WKNKDPTQWI ATFGATITPP AVKRNVRKII LHENYHRETN ENDIALVQLS
TGVEFSNIVQ RVCLPDSSIK LPPKTSVFVT GFGSIVDDGP IQNTLRQARV ETISTDVCNR
KDVYDGLITP GMLCAGFMEG KIDACKGDSG GPLVYDNHDI WYIVGIVSWG QSCALPKKPG
VYTRVTKYRD WIASKTGM
