ID   TM120_DICDI             Reviewed;         368 AA.
AC   Q54IK2;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Transmembrane protein 120 homolog;
GN   Name=tmem120; ORFNames=DDB_G0288699;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM120 family. {ECO:0000305}.
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DR   EMBL; AAFI02000120; EAL63081.1; -; Genomic_DNA.
DR   RefSeq; XP_636584.1; XM_631492.1.
DR   AlphaFoldDB; Q54IK2; -.
DR   SMR; Q54IK2; -.
DR   PaxDb; Q54IK2; -.
DR   EnsemblProtists; EAL63081; EAL63081; DDB_G0288699.
DR   GeneID; 8626757; -.
DR   KEGG; ddi:DDB_G0288699; -.
DR   dictyBase; DDB_G0288699; tmem120.
DR   eggNOG; KOG4758; Eukaryota.
DR   HOGENOM; CLU_048749_1_1_1; -.
DR   InParanoid; Q54IK2; -.
DR   OMA; TVNCALL; -.
DR   PhylomeDB; Q54IK2; -.
DR   PRO; PR:Q54IK2; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   InterPro; IPR012926; TACAN/TMEM120B.
DR   PANTHER; PTHR21433; PTHR21433; 1.
DR   Pfam; PF07851; TMPIT; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..368
FT                   /note="Transmembrane protein 120 homolog"
FT                   /id="PRO_0000327733"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        212..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        332..352
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          25..96
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   368 AA;  42871 MW;  0D87E1CAEE5974A4 CRC64;
     MMESFSETKS SIATNKSTTP THEVQISKEL QDIKNEVFEL KKSHEQCKEK GIKVKKDIND
     VFKHADDITN TLAKHEKESS QLISRIKHLN AKEKQLDITK ELSAHLDQIK VNVKRAKVSF
     TPETGSIFVR LFLGQVNVKH MRENEKFRLK QEYEKFKKKT NPQFILFVVL LLLYPQSSFV
     TTSWQIWLLY YYITLALREN ILLVNGSSIK PWWIMHHYLS IAGSLTNLLF PLSESFSYFL
     PQVTYFSGCQ GLVQILTNRY QQGRLYKLVA MGKANIIDVT GESEGWGNDP GWTPSALFLF
     PFLLFVQFFQ LYNSFSFFAF AYQRSGYVEW QVFSCGFIFL CLGLGNLLTT LSVYYQKWKN
     FSKYNKEN