ID   BST17_CAEEL             Reviewed;         481 AA.
AC   Q22566;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2021, sequence version 3.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Bestrophin homolog 17;
GN   Name=best-17 {ECO:0000312|WormBase:T19C3.1};
GN   ORFNames=T19C3.1 {ECO:0000312|WormBase:T19C3.1};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Forms chloride channels. {ECO:0000250}.
CC   -!- SUBUNIT: Forms oligomers. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the bestrophin family. {ECO:0000305}.
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DR   EMBL; BX284603; CCD73733.2; -; Genomic_DNA.
DR   RefSeq; NP_497218.2; NM_064817.2.
DR   AlphaFoldDB; Q22566; -.
DR   SMR; Q22566; -.
DR   BioGRID; 53246; 1.
DR   STRING; 6239.T19C3.1; -.
DR   iPTMnet; Q22566; -.
DR   EPD; Q22566; -.
DR   PaxDb; Q22566; -.
DR   PeptideAtlas; Q22566; -.
DR   EnsemblMetazoa; T19C3.1.1; T19C3.1.1; WBGene00020559.
DR   UCSC; T19C3.1; c. elegans.
DR   WormBase; T19C3.1; CE53916; WBGene00020559; best-17.
DR   eggNOG; KOG3547; Eukaryota.
DR   HOGENOM; CLU_018069_7_1_1; -.
DR   InParanoid; Q22566; -.
DR   OrthoDB; 279144at2759; -.
DR   PhylomeDB; Q22566; -.
DR   Reactome; R-CEL-2672351; Stimuli-sensing channels.
DR   PRO; PR:Q22566; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00020559; Expressed in material anatomical entity and 3 other tissues.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005254; F:chloride channel activity; IBA:GO_Central.
DR   InterPro; IPR000615; Bestrophin.
DR   InterPro; IPR021134; Bestrophin/UPF0187.
DR   PANTHER; PTHR10736; PTHR10736; 1.
DR   Pfam; PF01062; Bestrophin; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chloride; Chloride channel; Ion channel; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..481
FT                   /note="Bestrophin homolog 17"
FT                   /id="PRO_0000143132"
FT   TOPO_DOM        1..27
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        49..95
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        117..230
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        231..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        252..274
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        275..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        296..481
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   REGION          427..481
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        441..462
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   481 AA;  55149 MW;  78485D3247CB86E3 CRC64;
     MTVSYQLDVS SGNPLLFLRL LGRWRGSIWK SVVGDLFVWL LFYYAIYFAY RYAFSKQLQT
     VFEEISIHTD DRMKYLPLTF MLGFFVTTVF ERWRSALNVM PFIESVALSV AVLLPGKGRE
     DRLTRRAIIR YVVLHQILVF RDISMRVRRR FPTLKYVVDA GFMRQEELDV LESVNQESSQ
     TYWVPINWAN SLALVAHQQK LIDQPTAFNN VIFAIKEFRV AMETLIKFDA IPIPIAYPQV
     VFLAVRVYFA ICLVSRQFLI SDMKSKTQMD WPVPIMTVLE FIFVIGWMKV AEVLLNPLGE
     DDDDFEVNSI IDNNISRGMA IVDTTHGYHP DLVDDVFSDP NYLPAYSENS QIPRNLTGSA
     AKVELAAPTD EVKIVRVNPE DAPPTSERGS MFTRRNAYSL RNRKISIASN NLESPSQERK
     FNLSMPAGML NKSTQPDRPT METVSEEHEP SHFYRGDRVH SSDSGLSKTQ QSSEESVDKK
     G