ID   TM121_CHICK             Reviewed;         312 AA.
AC   Q8QFN3;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Transmembrane protein 121;
DE   AltName: Full=Protein hole;
GN   Name=TMEM121; Synonyms=HOLE;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC   TISSUE=Embryonic heart;
RX   PubMed=12204283; DOI=10.1016/s0925-4773(02)00213-7;
RA   Nesset A.L., Bader D.M.;
RT   "Hole is a novel gene product expressed in the developing heart and
RT   brain.";
RL   Mech. Dev. 117:347-350(2002).
CC   -!- FUNCTION: May play a role in MAPK signaling. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Note=May localize to the plasma membrane.
CC       {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the cardiac crescent and later in the
CC       myocardium in stages 4 to 25. {ECO:0000269|PubMed:12204283}.
CC   -!- SIMILARITY: Belongs to the TMEM121 family. {ECO:0000305}.
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DR   EMBL; AF488728; AAM08318.1; -; mRNA.
DR   RefSeq; NP_989870.1; NM_204539.1.
DR   RefSeq; XP_015145726.1; XM_015290240.1.
DR   AlphaFoldDB; Q8QFN3; -.
DR   STRING; 9031.ENSGALP00000004345; -.
DR   PaxDb; Q8QFN3; -.
DR   Ensembl; ENSGALT00000091209; ENSGALP00000070792; ENSGALG00000054831.
DR   GeneID; 395216; -.
DR   KEGG; gga:395216; -.
DR   CTD; 80757; -.
DR   VEuPathDB; HostDB:geneid_395216; -.
DR   eggNOG; ENOG502S0WC; Eukaryota.
DR   GeneTree; ENSGT00390000003866; -.
DR   HOGENOM; CLU_076106_0_0_1; -.
DR   InParanoid; Q8QFN3; -.
DR   OMA; GIPHEPS; -.
DR   OrthoDB; 978039at2759; -.
DR   PhylomeDB; Q8QFN3; -.
DR   TreeFam; TF328726; -.
DR   PRO; PR:Q8QFN3; -.
DR   Proteomes; UP000000539; Chromosome 8.
DR   Bgee; ENSGALG00000054831; Expressed in heart and 8 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR032776; CECR6/TMEM121.
DR   InterPro; IPR042314; TMEM121.
DR   PANTHER; PTHR31046; PTHR31046; 1.
DR   Pfam; PF14997; CECR6_TMEM121; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..312
FT                   /note="Transmembrane protein 121"
FT                   /id="PRO_0000251247"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        111..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          291..312
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   312 AA;  35676 MW;  B81E2E8DC9FCD58E CRC64;
     MVLPPPDKRH VCLTTIVIMT SMAFMDAYLV EQNQGPRKIG VCIIVLVGDI CFLIVLRYVA
     VWVGAEVKTA KRGYAMILWF LYIFVLEIKL YFIFQNYKAD KKNLETVARK ALTLLLSICV
     PGLYLVLVAL DSMEYIRTFR KKEDLRGRLF WVALDLLDIL DIQANLWEPH RTGLPIWAEG
     LMFFYCYILL LILPCVSLSE ISMQGEHIAP QKMMLYPVLS LVTINIVTIF IRAINMVLFQ
     DSRVSTIFIG KNIIAIATKA CTFLEYKRQV KEFPQNAIAL ELQQNSLSHN QTLHSTQGIP
     HEPSPTSEIL DT