TM121_HUMAN
ID TM121_HUMAN Reviewed; 319 AA.
AC Q9BTD3;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Transmembrane protein 121;
GN Name=TMEM121; Synonyms=HHOLE;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RX PubMed=15950185; DOI=10.1016/j.bbrc.2005.05.115;
RA Zhou J., Li Y., Liang P., Yuan W., Ye X., Zhu C., Cheng Y., Wang Y., Li G.,
RA Wu X., Liu M.;
RT "A novel six-transmembrane protein hhole functions as a suppressor in MAPK
RT signaling pathways.";
RL Biochem. Biophys. Res. Commun. 333:344-352(2005).
CC -!- FUNCTION: May play a role in MAPK signaling.
CC {ECO:0000269|PubMed:15950185}.
CC -!- INTERACTION:
CC Q9BTD3; P05067: APP; NbExp=3; IntAct=EBI-12155101, EBI-77613;
CC Q9BTD3; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-12155101, EBI-11343438;
CC Q9BTD3; Q08426: EHHADH; NbExp=3; IntAct=EBI-12155101, EBI-2339219;
CC Q9BTD3; P48165: GJA8; NbExp=3; IntAct=EBI-12155101, EBI-17458373;
CC Q9BTD3; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-12155101, EBI-11742507;
CC Q9BTD3; P15941-11: MUC1; NbExp=3; IntAct=EBI-12155101, EBI-17263240;
CC Q9BTD3; O43639: NCK2; NbExp=3; IntAct=EBI-12155101, EBI-713635;
CC Q9BTD3; O15160: POLR1C; NbExp=3; IntAct=EBI-12155101, EBI-1055079;
CC Q9BTD3; Q9H6H4: REEP4; NbExp=3; IntAct=EBI-12155101, EBI-7545592;
CC Q9BTD3; Q14973: SLC10A1; NbExp=3; IntAct=EBI-12155101, EBI-3923031;
CC Q9BTD3; Q6PL24: TMED8; NbExp=3; IntAct=EBI-12155101, EBI-11603430;
CC Q9BTD3; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-12155101, EBI-8638294;
CC Q9BTD3; Q9Y320: TMX2; NbExp=3; IntAct=EBI-12155101, EBI-6447886;
CC Q9BTD3; O43167: ZBTB24; NbExp=3; IntAct=EBI-12155101, EBI-744471;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}. Note=May localize to the plasma membrane.
CC {ECO:0000269|PubMed:15950185}.
CC -!- TISSUE SPECIFICITY: Highly expressed in heart and detected in pancreas,
CC liver and skeletal muscle. {ECO:0000269|PubMed:15950185}.
CC -!- DEVELOPMENTAL STAGE: Widely expressed in fetal tissues with high
CC expression in fetal heart. {ECO:0000269|PubMed:15950185}.
CC -!- SIMILARITY: Belongs to the TMEM121 family. {ECO:0000305}.
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DR EMBL; BC004221; AAH04221.1; -; mRNA.
DR CCDS; CCDS10006.1; -.
DR RefSeq; NP_001318167.1; NM_001331238.1.
DR RefSeq; NP_079544.1; NM_025268.3.
DR RefSeq; XP_006720324.1; XM_006720261.3.
DR AlphaFoldDB; Q9BTD3; -.
DR BioGRID; 123291; 15.
DR IntAct; Q9BTD3; 14.
DR STRING; 9606.ENSP00000376304; -.
DR iPTMnet; Q9BTD3; -.
DR PhosphoSitePlus; Q9BTD3; -.
DR BioMuta; TMEM121; -.
DR DMDM; 74733114; -.
DR PaxDb; Q9BTD3; -.
DR PeptideAtlas; Q9BTD3; -.
DR PRIDE; Q9BTD3; -.
DR ProteomicsDB; 78974; -.
DR Antibodypedia; 62348; 18 antibodies from 10 providers.
DR DNASU; 80757; -.
DR Ensembl; ENST00000392519.7; ENSP00000376304.2; ENSG00000184986.11.
DR Ensembl; ENST00000431372.1; ENSP00000407456.1; ENSG00000184986.11.
DR GeneID; 80757; -.
DR KEGG; hsa:80757; -.
DR MANE-Select; ENST00000392519.7; ENSP00000376304.2; NM_025268.4; NP_079544.1.
DR UCSC; uc001yrp.2; human.
DR CTD; 80757; -.
DR GeneCards; TMEM121; -.
DR HGNC; HGNC:20511; TMEM121.
DR HPA; ENSG00000184986; Low tissue specificity.
DR neXtProt; NX_Q9BTD3; -.
DR OpenTargets; ENSG00000184986; -.
DR PharmGKB; PA143485641; -.
DR VEuPathDB; HostDB:ENSG00000184986; -.
DR eggNOG; ENOG502S0WC; Eukaryota.
DR GeneTree; ENSGT00390000003866; -.
DR HOGENOM; CLU_076106_0_0_1; -.
DR InParanoid; Q9BTD3; -.
DR OMA; QATLWEP; -.
DR OrthoDB; 978039at2759; -.
DR PhylomeDB; Q9BTD3; -.
DR TreeFam; TF328726; -.
DR PathwayCommons; Q9BTD3; -.
DR SignaLink; Q9BTD3; -.
DR BioGRID-ORCS; 80757; 10 hits in 1073 CRISPR screens.
DR ChiTaRS; TMEM121; human.
DR GenomeRNAi; 80757; -.
DR Pharos; Q9BTD3; Tdark.
DR PRO; PR:Q9BTD3; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q9BTD3; protein.
DR Bgee; ENSG00000184986; Expressed in right frontal lobe and 102 other tissues.
DR Genevisible; Q9BTD3; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR032776; CECR6/TMEM121.
DR InterPro; IPR042314; TMEM121.
DR PANTHER; PTHR31046; PTHR31046; 1.
DR Pfam; PF14997; CECR6_TMEM121; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..319
FT /note="Transmembrane protein 121"
FT /id="PRO_0000251245"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 277..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..310
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 319 AA; 35814 MW; 931AD92F58D50F62 CRC64;
MVLPPPDRRH VCLTTLVIMG SMAVMDAYLV EQNQGPRKIG VCIIVLVGDV CFLLVLRYVA
VWVGAEVRTA KRGYAMILWF LYIFVLEIKL YFIFQNYKAA RRGAADPVAR KALTLLLSVC
VPGLFLLLVA LDRMEYVRTF RKREDLRGRL FWVALDLLDL LDMQASLWEP PRSGLPLWAE
GLTFFYCYML LLVLPCVALS EVSMQGEHIA PQKMMLYPVL SLATVNVVAV LARAANMALF
RDSRVSAIFV GKNVVALATK ACTFLEYRRQ VRDFPPPALS LELQPPPPQR NSVPPPPPPL
HGPPGRPHMS SPTRDPLDT
