ID   TM121_MOUSE             Reviewed;         318 AA.
AC   Q80XA0; Q8R3W8; Q8R4A5;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Transmembrane protein 121;
DE   AltName: Full=Protein hole;
GN   Name=Tmem121; Synonyms=Hole;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=12204283; DOI=10.1016/s0925-4773(02)00213-7;
RA   Nesset A.L., Bader D.M.;
RT   "Hole is a novel gene product expressed in the developing heart and
RT   brain.";
RL   Mech. Dev. 117:347-350(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Czech II; TISSUE=Eye, and Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May play a role in MAPK signaling. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Note=May localize to the plasma membrane.
CC       {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Displays strong neural pattern at 8.5 dpc to 12.5
CC       dpc. Not expressed in the heart. {ECO:0000269|PubMed:12204283}.
CC   -!- SIMILARITY: Belongs to the TMEM121 family. {ECO:0000305}.
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DR   EMBL; AF488729; AAM08319.1; -; mRNA.
DR   EMBL; BC023493; AAH23493.1; -; mRNA.
DR   EMBL; BC043474; AAH43474.1; -; mRNA.
DR   CCDS; CCDS26206.1; -.
DR   RefSeq; NP_722471.2; NM_153776.2.
DR   RefSeq; XP_006516264.1; XM_006516201.3.
DR   AlphaFoldDB; Q80XA0; -.
DR   STRING; 10090.ENSMUSP00000055994; -.
DR   iPTMnet; Q80XA0; -.
DR   PhosphoSitePlus; Q80XA0; -.
DR   PaxDb; Q80XA0; -.
DR   PRIDE; Q80XA0; -.
DR   ProteomicsDB; 259218; -.
DR   Antibodypedia; 62348; 18 antibodies from 10 providers.
DR   Ensembl; ENSMUST00000058491; ENSMUSP00000055994; ENSMUSG00000049036.
DR   GeneID; 69195; -.
DR   KEGG; mmu:69195; -.
DR   UCSC; uc007pgc.1; mouse.
DR   CTD; 80757; -.
DR   MGI; MGI:1916445; Tmem121.
DR   VEuPathDB; HostDB:ENSMUSG00000049036; -.
DR   eggNOG; ENOG502S0WC; Eukaryota.
DR   GeneTree; ENSGT00390000003866; -.
DR   HOGENOM; CLU_076106_0_0_1; -.
DR   InParanoid; Q80XA0; -.
DR   OMA; QATLWEP; -.
DR   OrthoDB; 978039at2759; -.
DR   PhylomeDB; Q80XA0; -.
DR   TreeFam; TF328726; -.
DR   BioGRID-ORCS; 69195; 5 hits in 72 CRISPR screens.
DR   PRO; PR:Q80XA0; -.
DR   Proteomes; UP000000589; Chromosome 12.
DR   RNAct; Q80XA0; protein.
DR   Bgee; ENSMUSG00000049036; Expressed in lumbar subsegment of spinal cord and 59 other tissues.
DR   Genevisible; Q80XA0; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR032776; CECR6/TMEM121.
DR   InterPro; IPR042314; TMEM121.
DR   PANTHER; PTHR31046; PTHR31046; 1.
DR   Pfam; PF14997; CECR6_TMEM121; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..318
FT                   /note="Transmembrane protein 121"
FT                   /id="PRO_0000251246"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        214..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          278..318
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        279..309
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   318 AA;  35684 MW;  1062B958CD20C4F6 CRC64;
     MVLPPPDRRH VCLTTLVIMG SMAVMDAYLV EQNQGPRKIG VCIIVLVGDV CFLLVLRYVA
     VWVGAEVRTA KRGYAMILWF LYIFVLEIKL YFIFQNYKAA RRGAADPVAR KALTLLLSVC
     VPGLFLLLVA LDRMEYVRTF RKREDLRGRL FWVALDLLDL LDMQANLWEP PRTGLPLWAE
     GLTFFYCYML LLVLPCVALS EVSMQGEHIA PQKMMLYPVL SLATVNVVAV LARAANMALF
     RDSRVSAIFV GKNVVALATK ACTFLEYRRQ VRDFPPPALA LELQPPPSQR NSVPPPPPLH
     GPPVRPHGPS PTRDALDT