TM125_MOUSE
ID TM125_MOUSE Reviewed; 216 AA.
AC Q8CHQ6; A2BI56; Q8BHY6;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Transmembrane protein 125;
GN Name=Tmem125;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RC TISSUE=Hypothalamus, Liver cancer, Medulla oblongata, and Spinal cord;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH39806.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC34092.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; BX842610; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK050146; BAC34092.1; ALT_FRAME; mRNA.
DR EMBL; AK160304; BAE35732.1; -; mRNA.
DR EMBL; AK162907; BAE37110.1; -; mRNA.
DR EMBL; AK162829; BAE37073.1; -; mRNA.
DR EMBL; BC039806; AAH39806.2; ALT_INIT; mRNA.
DR CCDS; CCDS51285.1; -.
DR RefSeq; NP_759015.2; NM_172383.3.
DR RefSeq; XP_006503076.1; XM_006503013.3.
DR RefSeq; XP_006503077.1; XM_006503014.2.
DR RefSeq; XP_011238797.1; XM_011240495.2.
DR RefSeq; XP_011238798.1; XM_011240496.2.
DR RefSeq; XP_017175638.1; XM_017320149.1.
DR AlphaFoldDB; Q8CHQ6; -.
DR STRING; 10090.ENSMUSP00000063157; -.
DR PhosphoSitePlus; Q8CHQ6; -.
DR PaxDb; Q8CHQ6; -.
DR PRIDE; Q8CHQ6; -.
DR ProteomicsDB; 259524; -.
DR Antibodypedia; 18202; 35 antibodies from 10 providers.
DR Ensembl; ENSMUST00000060214; ENSMUSP00000063157; ENSMUSG00000050854.
DR GeneID; 230678; -.
DR KEGG; mmu:230678; -.
DR UCSC; uc012dkb.1; mouse.
DR CTD; 128218; -.
DR MGI; MGI:1923409; Tmem125.
DR VEuPathDB; HostDB:ENSMUSG00000050854; -.
DR eggNOG; ENOG502S0IK; Eukaryota.
DR GeneTree; ENSGT00390000003015; -.
DR HOGENOM; CLU_118850_0_0_1; -.
DR InParanoid; Q8CHQ6; -.
DR OMA; EHVELWW; -.
DR OrthoDB; 1443352at2759; -.
DR TreeFam; TF332758; -.
DR BioGRID-ORCS; 230678; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q8CHQ6; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8CHQ6; protein.
DR Bgee; ENSMUSG00000050854; Expressed in lumbar subsegment of spinal cord and 144 other tissues.
DR ExpressionAtlas; Q8CHQ6; baseline and differential.
DR Genevisible; Q8CHQ6; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR028165; TMEM125.
DR PANTHER; PTHR31416; PTHR31416; 1.
DR Pfam; PF15109; TMEM125; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..216
FT /note="Transmembrane protein 125"
FT /id="PRO_0000251717"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 57
FT /note="S -> T (in Ref. 2; BAC34092)"
FT /evidence="ECO:0000305"
FT CONFLICT 66
FT /note="A -> P (in Ref. 2; BAC34092)"
FT /evidence="ECO:0000305"
FT CONFLICT 81
FT /note="K -> N (in Ref. 2; BAC34092)"
FT /evidence="ECO:0000305"
FT CONFLICT 112
FT /note="V -> D (in Ref. 2; BAC34092)"
FT /evidence="ECO:0000305"
FT CONFLICT 188
FT /note="G -> S (in Ref. 2; BAC34092)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 216 AA; 22055 MW; F2AA995BF1F83DD7 CRC64;
MSQQASVGRG LPPDVLAEQV ELWWSQQPRR SLLCFSVAVI LVAGCGAGGV ALLSSTSSRS
GEWRLAVGTV LCLLALLVLV KQLMSSAVQD MNCIRQAQHV ALLRSGGGAD AVVVLLSGFV
LLVTGLTLAG LAAAPAPARP LAAMLSVGIT LASLGSVLLL GLLLYQVGVS GHCPPICTEA
FSAQNGHGDN SSIFSISGQL SSGQRHETTS SIASLI
