TM127_MOUSE
ID TM127_MOUSE Reviewed; 238 AA.
AC Q8BGP5; A2ARF9; Q3TMK7;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Transmembrane protein 127;
GN Name=Tmem127;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Liver, Lung, Ovary, and Uterus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Controls cell proliferation acting as a negative regulator of
CC TOR signaling pathway mediated by mTORC1. May act as a tumor
CC suppressor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Association of
CC TMEM127 with the cell membrane is enhanced by inhibition of
CC endocytosis. In the cytoplasm, it colocalizes with markers of early
CC endosomal structures, Golgi apparatus and lysosomes. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TMEM127 family. {ECO:0000305}.
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DR EMBL; AK030324; BAC26902.1; -; mRNA.
DR EMBL; AK050216; BAC34129.1; -; mRNA.
DR EMBL; AK165880; BAE38434.1; -; mRNA.
DR EMBL; AL845368; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC049832; AAH49832.1; -; mRNA.
DR CCDS; CCDS16697.1; -.
DR RefSeq; NP_780354.1; NM_175145.3.
DR AlphaFoldDB; Q8BGP5; -.
DR STRING; 10090.ENSMUSP00000035434; -.
DR iPTMnet; Q8BGP5; -.
DR PhosphoSitePlus; Q8BGP5; -.
DR MaxQB; Q8BGP5; -.
DR PaxDb; Q8BGP5; -.
DR PRIDE; Q8BGP5; -.
DR ProteomicsDB; 259525; -.
DR Antibodypedia; 32415; 44 antibodies from 18 providers.
DR DNASU; 69470; -.
DR Ensembl; ENSMUST00000035871; ENSMUSP00000035434; ENSMUSG00000034850.
DR GeneID; 69470; -.
DR KEGG; mmu:69470; -.
DR UCSC; uc008mfc.1; mouse.
DR CTD; 55654; -.
DR MGI; MGI:1916720; Tmem127.
DR VEuPathDB; HostDB:ENSMUSG00000034850; -.
DR eggNOG; ENOG502QTCN; Eukaryota.
DR GeneTree; ENSGT00390000005154; -.
DR InParanoid; Q8BGP5; -.
DR OMA; MEETEPY; -.
DR OrthoDB; 1422066at2759; -.
DR PhylomeDB; Q8BGP5; -.
DR TreeFam; TF328671; -.
DR BioGRID-ORCS; 69470; 15 hits in 77 CRISPR screens.
DR ChiTaRS; Tmem127; mouse.
DR PRO; PR:Q8BGP5; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8BGP5; protein.
DR Bgee; ENSMUSG00000034850; Expressed in otolith organ and 222 other tissues.
DR ExpressionAtlas; Q8BGP5; baseline and differential.
DR Genevisible; Q8BGP5; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005769; C:early endosome; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0031267; F:small GTPase binding; ISO:MGI.
DR GO; GO:0007032; P:endosome organization; IMP:MGI.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:MGI.
DR GO; GO:0032007; P:negative regulation of TOR signaling; ISO:MGI.
DR GO; GO:0032006; P:regulation of TOR signaling; IMP:MGI.
DR InterPro; IPR033331; TMEM127.
DR PANTHER; PTHR28358; PTHR28358; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Cell membrane; Cytoplasm; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix; Tumor suppressor.
FT CHAIN 1..238
FT /note="Transmembrane protein 127"
FT /id="PRO_0000251719"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:O75204"
FT MOD_RES 17
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O75204"
SQ SEQUENCE 238 AA; 25835 MW; 80CB57F832B7C68D CRC64;
MYAPGGAGLP GGRRRRSPGS SALPKQPERS LASALPGALS ITALCTALAE PAWLHIHGGT
CSRQELGVSD VLGYVNPDLL KDFCMNPQTV LLLRVIAAFC FLGILCSLSA FLLDVFGPKH
PALKITRRYA FAHILTVLQC ATVIGFSYWA SELILAQQQQ HKKYHGSQVY VTFAVSFYLV
AGAGGASILA TAANLLRHYP TEEEEQALEL LSEMEENDPY PAEYEVINQF QPPPAYTP
