BST18_CAEEL
ID BST18_CAEEL Reviewed; 456 AA.
AC P34577;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2002, sequence version 2.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Bestrophin homolog 18;
GN Name=best-18; ORFNames=T20G5.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Forms chloride channels. {ECO:0000250}.
CC -!- SUBUNIT: Forms oligomers. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the bestrophin family. {ECO:0000305}.
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DR EMBL; Z30423; CAA83005.2; -; Genomic_DNA.
DR PIR; S42371; S42371.
DR RefSeq; NP_001255067.1; NM_001268138.1.
DR AlphaFoldDB; P34577; -.
DR SMR; P34577; -.
DR STRING; 6239.T20G5.4a; -.
DR PaxDb; P34577; -.
DR PRIDE; P34577; -.
DR EnsemblMetazoa; T20G5.4a.1; T20G5.4a.1; WBGene00011868.
DR GeneID; 176436; -.
DR KEGG; cel:CELE_T20G5.4; -.
DR UCSC; T20G5.4; c. elegans.
DR CTD; 176436; -.
DR WormBase; T20G5.4a; CE28844; WBGene00011868; best-18.
DR eggNOG; KOG3547; Eukaryota.
DR HOGENOM; CLU_018069_7_1_1; -.
DR InParanoid; P34577; -.
DR OMA; FIDNIAC; -.
DR OrthoDB; 279144at2759; -.
DR PhylomeDB; P34577; -.
DR Reactome; R-CEL-2672351; Stimuli-sensing channels.
DR PRO; PR:P34577; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00011868; Expressed in larva and 3 other tissues.
DR ExpressionAtlas; P34577; baseline and differential.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005254; F:chloride channel activity; IBA:GO_Central.
DR InterPro; IPR000615; Bestrophin.
DR InterPro; IPR021134; Bestrophin/UPF0187.
DR PANTHER; PTHR10736; PTHR10736; 1.
DR Pfam; PF01062; Bestrophin; 1.
PE 3: Inferred from homology;
KW Cell membrane; Chloride; Chloride channel; Ion channel; Ion transport;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..456
FT /note="Bestrophin homolog 18"
FT /id="PRO_0000143133"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..287
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 416..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 416..444
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 456 AA; 53137 MW; EDE22B541307F3C8 CRC64;
MTVSYNQSVA TSRPWTFLAL IFRWRGSVWS AIWIQYSVWL GLYFLVSAIY RFILSAYQQQ
IFVRLVDYVN SRMSYVPLDW MLGFFIAGVL RRFWYLYDII GFIDNIACST ATYIRGDSER
AKQYRRNIIR YCELTQVLIF RDLSMKARKR FPTLDTVAAA GFMMPHEKAN FDLIQYNYNK
YFLPFNWAWA LVYNARKEGL IEGDYYVTVI SEDIKKFRTG LAWVCNYDWV PLPIIYPTIV
CLAVHMYFFV GILARQYVKG SEIDPDMIDL VFPFMTSIQF VFYMGWLKVG EGLLNPWGED
PDDFETNMLI DRNLAMGLKI VDEGYDKTPR LEKDAFWDDT WVPLYSEASA HEKRYHQRQG
SLAHIKIGRS VSQVRMVPRD GRRASIVKER IVNVKPGSGI GDILRPSSLL NLMKHASSSR
SLERQRSPGS FRMETLTPGS PTNTPIEPID KIDKKK
