TM128_HUMAN
ID TM128_HUMAN Reviewed; 165 AA.
AC Q5BJH2; B4DHS7; D3DVS1; D3DVS3; Q5H9U6; Q96I94;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Transmembrane protein 128;
GN Name=TMEM128;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ILE-16.
RC TISSUE=Caudate nucleus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP ILE-16.
RC TISSUE=Placenta, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q5BJH2; Q9BXK5: BCL2L13; NbExp=3; IntAct=EBI-10243515, EBI-747430;
CC Q5BJH2-2; Q13520: AQP6; NbExp=3; IntAct=EBI-10694905, EBI-13059134;
CC Q5BJH2-2; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-10694905, EBI-11343438;
CC Q5BJH2-2; Q8NFU1: BEST2; NbExp=3; IntAct=EBI-10694905, EBI-19947314;
CC Q5BJH2-2; P25942: CD40; NbExp=3; IntAct=EBI-10694905, EBI-525714;
CC Q5BJH2-2; P19397: CD53; NbExp=3; IntAct=EBI-10694905, EBI-6657396;
CC Q5BJH2-2; P11912: CD79A; NbExp=3; IntAct=EBI-10694905, EBI-7797864;
CC Q5BJH2-2; O00501: CLDN5; NbExp=3; IntAct=EBI-10694905, EBI-18400628;
CC Q5BJH2-2; O95471: CLDN7; NbExp=3; IntAct=EBI-10694905, EBI-740744;
CC Q5BJH2-2; P49447: CYB561; NbExp=3; IntAct=EBI-10694905, EBI-8646596;
CC Q5BJH2-2; Q9BQA9: CYBC1; NbExp=3; IntAct=EBI-10694905, EBI-2680384;
CC Q5BJH2-2; Q9GZR5: ELOVL4; NbExp=3; IntAct=EBI-10694905, EBI-18535450;
CC Q5BJH2-2; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-10694905, EBI-781551;
CC Q5BJH2-2; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-10694905, EBI-18304435;
CC Q5BJH2-2; Q05329: GAD2; NbExp=3; IntAct=EBI-10694905, EBI-9304251;
CC Q5BJH2-2; P17302: GJA1; NbExp=3; IntAct=EBI-10694905, EBI-1103439;
CC Q5BJH2-2; P48165: GJA8; NbExp=3; IntAct=EBI-10694905, EBI-17458373;
CC Q5BJH2-2; O95377: GJB5; NbExp=3; IntAct=EBI-10694905, EBI-3909454;
CC Q5BJH2-2; Q5T7V8: GORAB; NbExp=3; IntAct=EBI-10694905, EBI-3917143;
CC Q5BJH2-2; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-10694905, EBI-13345167;
CC Q5BJH2-2; Q8TED1: GPX8; NbExp=3; IntAct=EBI-10694905, EBI-11721746;
CC Q5BJH2-2; P62993: GRB2; NbExp=3; IntAct=EBI-10694905, EBI-401755;
CC Q5BJH2-2; Q8NBQ5: HSD17B11; NbExp=3; IntAct=EBI-10694905, EBI-1052304;
CC Q5BJH2-2; Q9Y5U9: IER3IP1; NbExp=3; IntAct=EBI-10694905, EBI-725665;
CC Q5BJH2-2; P26951: IL3RA; NbExp=3; IntAct=EBI-10694905, EBI-1757512;
CC Q5BJH2-2; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-10694905, EBI-10266796;
CC Q5BJH2-2; O95279: KCNK5; NbExp=3; IntAct=EBI-10694905, EBI-3934936;
CC Q5BJH2-2; A8MZ59: LEUTX; NbExp=3; IntAct=EBI-10694905, EBI-17490413;
CC Q5BJH2-2; Q6ZUX7: LHFPL2; NbExp=3; IntAct=EBI-10694905, EBI-17566767;
CC Q5BJH2-2; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-10694905, EBI-2820517;
CC Q5BJH2-2; Q9GZY8-5: MFF; NbExp=3; IntAct=EBI-10694905, EBI-11956541;
CC Q5BJH2-2; Q6N075: MFSD5; NbExp=3; IntAct=EBI-10694905, EBI-3920969;
CC Q5BJH2-2; Q9Y676: MRPS18B; NbExp=3; IntAct=EBI-10694905, EBI-750085;
CC Q5BJH2-2; Q99551: MTERF1; NbExp=3; IntAct=EBI-10694905, EBI-2690033;
CC Q5BJH2-2; Q9H2K0: MTIF3; NbExp=3; IntAct=EBI-10694905, EBI-3923617;
CC Q5BJH2-2; P15941-11: MUC1; NbExp=3; IntAct=EBI-10694905, EBI-17263240;
CC Q5BJH2-2; Q9H6H4: REEP4; NbExp=3; IntAct=EBI-10694905, EBI-7545592;
CC Q5BJH2-2; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-10694905, EBI-10192441;
CC Q5BJH2-2; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-10694905, EBI-17247926;
CC Q5BJH2-2; Q9BY50: SEC11C; NbExp=3; IntAct=EBI-10694905, EBI-2855401;
CC Q5BJH2-2; Q3SXP7: SHISAL1; NbExp=3; IntAct=EBI-10694905, EBI-18037857;
CC Q5BJH2-2; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-10694905, EBI-18159983;
CC Q5BJH2-2; P54219-3: SLC18A1; NbExp=3; IntAct=EBI-10694905, EBI-17595455;
CC Q5BJH2-2; P43003: SLC1A3; NbExp=3; IntAct=EBI-10694905, EBI-359038;
CC Q5BJH2-2; Q9BXS9-3: SLC26A6; NbExp=3; IntAct=EBI-10694905, EBI-12814225;
CC Q5BJH2-2; O95436-2: SLC34A2; NbExp=3; IntAct=EBI-10694905, EBI-12811757;
CC Q5BJH2-2; Q8TBB6: SLC7A14; NbExp=3; IntAct=EBI-10694905, EBI-5235586;
CC Q5BJH2-2; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-10694905, EBI-17280858;
CC Q5BJH2-2; Q16623: STX1A; NbExp=3; IntAct=EBI-10694905, EBI-712466;
CC Q5BJH2-2; Q96A25: TMEM106A; NbExp=3; IntAct=EBI-10694905, EBI-3915978;
CC Q5BJH2-2; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-10694905, EBI-10982110;
CC Q5BJH2-2; Q96B21: TMEM45B; NbExp=3; IntAct=EBI-10694905, EBI-3923061;
CC Q5BJH2-2; Q4KMG9: TMEM52B; NbExp=3; IntAct=EBI-10694905, EBI-18178701;
CC Q5BJH2-2; Q96HE8: TMEM80; NbExp=3; IntAct=EBI-10694905, EBI-11742770;
CC Q5BJH2-2; O15393-2: TMPRSS2; NbExp=3; IntAct=EBI-10694905, EBI-12345267;
CC Q5BJH2-2; Q9Y320: TMX2; NbExp=3; IntAct=EBI-10694905, EBI-6447886;
CC Q5BJH2-2; Q96MV8: ZDHHC15; NbExp=3; IntAct=EBI-10694905, EBI-12837904;
CC Q5BJH2-2; Q5T4F4: ZFYVE27; NbExp=3; IntAct=EBI-10694905, EBI-3892947;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5BJH2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5BJH2-2; Sequence=VSP_021229;
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DR EMBL; AK295248; BAG58239.1; -; mRNA.
DR EMBL; CR933611; CAI45928.1; -; mRNA.
DR EMBL; AC011744; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471131; EAW82440.1; -; Genomic_DNA.
DR EMBL; CH471131; EAW82441.1; -; Genomic_DNA.
DR EMBL; CH471131; EAW82442.1; -; Genomic_DNA.
DR EMBL; CH471131; EAW82443.1; -; Genomic_DNA.
DR EMBL; CH471131; EAW82444.1; -; Genomic_DNA.
DR EMBL; BC007729; AAH07729.1; -; mRNA.
DR EMBL; BC091482; AAH91482.1; -; mRNA.
DR CCDS; CCDS3373.1; -. [Q5BJH2-2]
DR CCDS; CCDS75099.1; -. [Q5BJH2-1]
DR RefSeq; NP_001284480.1; NM_001297551.1. [Q5BJH2-1]
DR RefSeq; NP_001284481.1; NM_001297552.1. [Q5BJH2-1]
DR RefSeq; NP_116316.1; NM_032927.3. [Q5BJH2-2]
DR RefSeq; XP_005248091.1; XM_005248034.2. [Q5BJH2-1]
DR AlphaFoldDB; Q5BJH2; -.
DR BioGRID; 124428; 87.
DR IntAct; Q5BJH2; 59.
DR STRING; 9606.ENSP00000372201; -.
DR TCDB; 9.B.202.1.1; the 4 tms tmem128 (tmem128) family.
DR BioMuta; TMEM128; -.
DR DMDM; 74736022; -.
DR EPD; Q5BJH2; -.
DR jPOST; Q5BJH2; -.
DR MassIVE; Q5BJH2; -.
DR MaxQB; Q5BJH2; -.
DR PaxDb; Q5BJH2; -.
DR PeptideAtlas; Q5BJH2; -.
DR PRIDE; Q5BJH2; -.
DR ProteomicsDB; 12769; -.
DR ProteomicsDB; 62691; -. [Q5BJH2-1]
DR Antibodypedia; 51629; 10 antibodies from 7 providers.
DR DNASU; 85013; -.
DR Ensembl; ENST00000254742.6; ENSP00000254742.2; ENSG00000132406.12. [Q5BJH2-2]
DR Ensembl; ENST00000382753.5; ENSP00000372201.4; ENSG00000132406.12. [Q5BJH2-1]
DR GeneID; 85013; -.
DR KEGG; hsa:85013; -.
DR MANE-Select; ENST00000382753.5; ENSP00000372201.4; NM_001297551.2; NP_001284480.1.
DR UCSC; uc003ghq.2; human. [Q5BJH2-1]
DR UCSC; uc003ghr.2; human.
DR CTD; 85013; -.
DR DisGeNET; 85013; -.
DR GeneCards; TMEM128; -.
DR HGNC; HGNC:28201; TMEM128.
DR HPA; ENSG00000132406; Low tissue specificity.
DR neXtProt; NX_Q5BJH2; -.
DR OpenTargets; ENSG00000132406; -.
DR PharmGKB; PA143485648; -.
DR VEuPathDB; HostDB:ENSG00000132406; -.
DR eggNOG; ENOG502RZ1U; Eukaryota.
DR GeneTree; ENSGT00390000012901; -.
DR HOGENOM; CLU_117906_1_0_1; -.
DR InParanoid; Q5BJH2; -.
DR OMA; QFMGIVM; -.
DR OrthoDB; 1309550at2759; -.
DR PhylomeDB; Q5BJH2; -.
DR TreeFam; TF328406; -.
DR PathwayCommons; Q5BJH2; -.
DR SignaLink; Q5BJH2; -.
DR BioGRID-ORCS; 85013; 5 hits in 1049 CRISPR screens.
DR ChiTaRS; TMEM128; human.
DR GenomeRNAi; 85013; -.
DR Pharos; Q5BJH2; Tdark.
DR PRO; PR:Q5BJH2; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q5BJH2; protein.
DR Bgee; ENSG00000132406; Expressed in oocyte and 188 other tissues.
DR Genevisible; Q5BJH2; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR033579; TMEM128.
DR PANTHER; PTHR31134; PTHR31134; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..165
FT /note="Transmembrane protein 128"
FT /id="PRO_0000254556"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..32
FT /note="MDSSRARQQLRRRFLLLPDAEAQLDREGDAGP -> MPPFGYKT (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_021229"
FT VARIANT 16
FT /note="L -> I (in dbSNP:rs6854167)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_080190"
FT CONFLICT 43
FT /note="K -> E (in Ref. 2; CAI45928)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 165 AA; 18822 MW; C1A4890B243C7AEF CRC64;
MDSSRARQQL RRRFLLLPDA EAQLDREGDA GPETSTAVEK KEKPLPRLNI HSGFWILASI
VVTYYVDFFK TLKENFHTSS WFLCGSALLL VSLSIAFYCI VYLEWYCGIG EYDVKYPALI
PITTASFIAA GICFNIALWH VWSFFTPLLL FTQFMGVVMF ITLLG
