TM128_MOUSE
ID TM128_MOUSE Reviewed; 163 AA.
AC Q9CZB9; Q8BNQ8; Q9CYX2;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Transmembrane protein 128;
GN Name=Tmem128;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina, Egg, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, FVB/N, and NMRI; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK012789; BAB28471.2; -; mRNA.
DR EMBL; AK013227; BAB28726.1; -; mRNA.
DR EMBL; AK076679; BAC36442.1; -; mRNA.
DR EMBL; AK080853; BAC38045.1; -; mRNA.
DR EMBL; AK162257; BAE36819.1; -; mRNA.
DR EMBL; BC025197; AAH25197.1; -; mRNA.
DR EMBL; BC060969; AAH60969.1; -; mRNA.
DR EMBL; BC110310; AAI10311.1; -; mRNA.
DR CCDS; CCDS19254.1; -.
DR RefSeq; NP_079756.2; NM_025480.3.
DR RefSeq; XP_006504109.1; XM_006504046.2.
DR AlphaFoldDB; Q9CZB9; -.
DR STRING; 10090.ENSMUSP00000084788; -.
DR EPD; Q9CZB9; -.
DR MaxQB; Q9CZB9; -.
DR PaxDb; Q9CZB9; -.
DR PeptideAtlas; Q9CZB9; -.
DR PRIDE; Q9CZB9; -.
DR ProteomicsDB; 260672; -.
DR Antibodypedia; 51629; 10 antibodies from 7 providers.
DR DNASU; 66309; -.
DR Ensembl; ENSMUST00000087511; ENSMUSP00000084788; ENSMUSG00000067365.
DR Ensembl; ENSMUST00000119047; ENSMUSP00000113758; ENSMUSG00000067365.
DR GeneID; 66309; -.
DR KEGG; mmu:66309; -.
DR UCSC; uc008xgj.1; mouse.
DR CTD; 85013; -.
DR MGI; MGI:1913559; Tmem128.
DR VEuPathDB; HostDB:ENSMUSG00000067365; -.
DR eggNOG; ENOG502RZ1U; Eukaryota.
DR GeneTree; ENSGT00390000012901; -.
DR HOGENOM; CLU_117906_1_0_1; -.
DR InParanoid; Q9CZB9; -.
DR OMA; QFMGIVM; -.
DR OrthoDB; 1309550at2759; -.
DR PhylomeDB; Q9CZB9; -.
DR TreeFam; TF328406; -.
DR BioGRID-ORCS; 66309; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Tmem128; mouse.
DR PRO; PR:Q9CZB9; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q9CZB9; protein.
DR Bgee; ENSMUSG00000067365; Expressed in spermatocyte and 250 other tissues.
DR ExpressionAtlas; Q9CZB9; baseline and differential.
DR Genevisible; Q9CZB9; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR033579; TMEM128.
DR PANTHER; PTHR31134; PTHR31134; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..163
FT /note="Transmembrane protein 128"
FT /id="PRO_0000254557"
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 33
FT /note="P -> H (in Ref. 1; BAC38045)"
FT /evidence="ECO:0000305"
FT CONFLICT 137..139
FT /note="WNV -> GNG (in Ref. 1; BAC38045)"
FT /evidence="ECO:0000305"
FT CONFLICT 146..147
FT /note="LL -> WV (in Ref. 1; BAC38045)"
FT /evidence="ECO:0000305"
FT CONFLICT 151
FT /note="Q -> P (in Ref. 1; BAC38045)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 163 AA; 19069 MW; 5D402A50390613C6 CRC64;
MDAPWAREQL RRRYLFPSEV ELDCEDEAKP ETPTAVEKKE RPLPRLNIHS GFWILASIVV
TYYVDFFKTF KENFHTNSWF LFGGALLFVS LSIAFYCIVY LEWYRGIEEY DVKYPTLVPI
TTATFIAAGI CFNLALWNVW SFFTPLLLFT QFMGVVMFIS LLG
