TM130_MOUSE
ID TM130_MOUSE Reviewed; 419 AA.
AC Q6NXM3; Q8C4P6;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Transmembrane protein 130;
DE Flags: Precursor;
GN Name=Tmem130;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Fetal brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 197-419.
RC STRAIN=C57BL/6J; TISSUE=Embryonic head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-
CC pass type I membrane protein {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC38251.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BC067004; AAH67004.1; -; mRNA.
DR EMBL; BC127616; AAI27617.1; -; mRNA.
DR EMBL; BC127617; AAI27618.1; -; mRNA.
DR EMBL; AK081543; BAC38251.1; ALT_INIT; mRNA.
DR CCDS; CCDS19851.1; -.
DR RefSeq; NP_808403.2; NM_177735.4.
DR AlphaFoldDB; Q6NXM3; -.
DR STRING; 10090.ENSMUSP00000061100; -.
DR GlyGen; Q6NXM3; 3 sites.
DR iPTMnet; Q6NXM3; -.
DR PhosphoSitePlus; Q6NXM3; -.
DR MaxQB; Q6NXM3; -.
DR PaxDb; Q6NXM3; -.
DR PRIDE; Q6NXM3; -.
DR ProteomicsDB; 258901; -.
DR Antibodypedia; 2578; 25 antibodies from 11 providers.
DR DNASU; 243339; -.
DR Ensembl; ENSMUST00000061446; ENSMUSP00000061100; ENSMUSG00000043388.
DR GeneID; 243339; -.
DR KEGG; mmu:243339; -.
DR UCSC; uc009als.1; mouse.
DR CTD; 222865; -.
DR MGI; MGI:3607706; Tmem130.
DR VEuPathDB; HostDB:ENSMUSG00000043388; -.
DR eggNOG; ENOG502QSPZ; Eukaryota.
DR GeneTree; ENSGT00950000183188; -.
DR HOGENOM; CLU_767189_0_0_1; -.
DR InParanoid; Q6NXM3; -.
DR OMA; NCWLCRP; -.
DR OrthoDB; 892333at2759; -.
DR PhylomeDB; Q6NXM3; -.
DR TreeFam; TF336431; -.
DR BioGRID-ORCS; 243339; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Tmem130; mouse.
DR PRO; PR:Q6NXM3; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q6NXM3; protein.
DR Bgee; ENSMUSG00000043388; Expressed in dorsomedial nucleus of hypothalamus and 119 other tissues.
DR Genevisible; Q6NXM3; MM.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR045219; PKAT.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR PANTHER; PTHR11861; PTHR11861; 1.
DR Pfam; PF00801; PKD; 1.
DR SUPFAM; SSF49299; SSF49299; 2.
DR PROSITE; PS50093; PKD; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Golgi apparatus; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..419
FT /note="Transmembrane protein 130"
FT /id="PRO_0000278277"
FT TOPO_DOM 26..336
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 358..419
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 144..230
FT /note="PKD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00151"
FT CARBOHYD 29
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 85
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 194
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 419 AA; 46628 MW; EF82D04A7344D783 CRC64;
MAKATDVLVF WFACLLLLGP ARVAAGLYNL SLTADGPATV GTEVTISASL EVKDNGSLPL
PADTHLYRFH WIHTPLTLTA KNEKNLTSTI HVVGGVPGDF PISVWVTAVD CWVCQPLARS
TLLLPIKESL VGNIVVTQNT SLSWPNSYIT KRSLRLSFLL HDPSDFFKSA SFFYRWDFGD
GTLLITDNPV VYYNYSSPGT FTVKVRVVAE WEQIKPDTTK GTIQKTGDFS ASLDLRESLQ
GIQILGPTLL QTFQKLTMNL NFFGSPPLHV CWGLKPQCLP LEDRECHAVL VTRTSFNLTH
VFQDPGDYCF IFRAENAISK AHQYHRIQVW PSSFQPFVFA FPCATLITVL LVFLMYMTVR
SAATQKDIVE SPGATGLKCC CQVCCGSLFL DSPSEYLEIV RENHGLLPPL YKPVKTYNV
